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Biomedical subjects

L Urai

Publications and source records attributed to L Urai.

At least 19 recordsLinked to original sources

Scleroderma-heart and conduction disturbances.

Disturbances of impulse formation and conduction may arise in the early stage of scleroderma, as a sign of cardiac involvement, termed "scleroderma heart". The incidence of various intraventricular conduction disturbances and their association with other disorders of cardiac rhythm were analysed in 193 scleroderma-patients by age. The presence of ventricular conduction abnormalities was found to carry an increased hazard of the production of disorders of atrioventricular conduction and of abnormal impulse formation. The patients were also followed up for deviation of the R axis in the frontal plane. Septal hypertrophy was found more frequently in patients with intraventricular conduction disturbances than in those free from disorders of this type.

Adult↗

Ultrastructural investigations of finger pulp biopsies: a study of 31 patients with Raynaud's syndrome.

Finger pulp biopsies of 31 patients suffering from Raynaud's syndrome (RS) were investigated by light and electron microscopy. The patients suffered from various underlying diseases. Interest was focused on the vascular changes and nerve and connective tissue alterations, especially the elastic fiber changes. In the dermal capillaries, endothelial swelling, narrowing of the lumen, increased numbers of intracytoplasmic filaments and Weibel-Palade bodies, and various types of basement membrane alterations were observed. The basement membrane of the unmyelinated nerves showed similar alterations to the capillary basement membrane. Severe degenerative changes were found in the myelin sheath of the myelinated axons. In the dermal connective tissue, severe elastotic degeneration and alterations of the collagen fibers were observed. The data probably represent the ultrastructural picture of the end stage of this syndrome.

Adult↗