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Biomedical subjects

L V Chopikashvili

Publications and source records attributed to L V Chopikashvili.

9 recordsLinked to original sources
PubMed1993

[Modification with ascorbic acid of the level of spontaneous and induced chromosome aberrations and sister chromatid exchanges in lymphocytes of workers in contact with molybdenum salts].

Five workers of molybdenum gilding at the metallurgical works were observed prior to and after administration of ascorbic acid. Tests for chromosomal aberrations (CA) and sister chromatid exchanges (SCE) were used as the criteria for estimation. Individual sensitivity to the chemicals was revealed in the workers. Administration of ascorbic acid caused reduction of the level of chromosomal structural rearrangements.

Ascorbic Acid↗
PubMed1990

[Protective effect of ascorbic acid in cells of people exposed to cobalt chloride].

The workers contacting with cobalt chloride for 10 years and more have been receiving 50 mg ascorbic acid for 30 days. DNA repair was analysed after this procedure in lymphocytes cultivated in vitro according to following criteria: reactivation and induced mutagenesis of vaccinia virus as well as formation of DNA breaks and their resynthesis upon treatment with cobalt chloride and 4-nitro-quinoline-1-oxide.

4-Nitroquinoline-1-oxide↗
PubMed1989

[Decrease in repair processes in lymphocytes of workers exposed to heavy metals].

Mechanisms of DNA repair in lymphocytes of persons having occupational contact with heavy metal salts for at least 10 years were investigated. The long-term exposure to heavy metal salts did not result in development of mechanisms of adaptation to the respective metals, as shown by increased DNA sensitivity to these compounds and by decrease in the repair activity. However, in some cases, resistance to other mutagens, 4-NQO, in particular, was observed.

Cobalt↗
PubMedDate not supplied

[The genetic action of ammonium molybdate and cadmium chloride and iodide].

Ammonium molybdate cadmium iodide and cadmium chloride have been studied in test for their genotoxic effect on induction of DNA-cellular bonding, extrasynthesis of DNA in spermatozoa of mice as well as in test to estimate a fertility criterion of Drosophila males. Ammonium molybdate, cadmium iodide and cadmium chloride are stated to be able to induce injuries of native DNA in test on induction of DNA-cellular bonding and DNA-sex cells of mice and Drosophila melanogaster in dominant-lethal test and in experiments on estimation of a fertility coefficient of Drosophila males, respectively.

Animals↗
PubMedDate not supplied

[Genotoxic effects of molybdenum and its derivatives in an experiment on Drosophila and mammals].

As a result of research it is established that molybdenum shows the most pronounced genetic activity at the early stages of spermatogenesis. Genetic effects of molybdenum and its modification by vitamin S are registered in the test of dominant lethal mutations. The cytogenetic activity of molybdenum, the molybdenic candle-end and its modification by antibacterial preparation have been revealed in the cells of mammalian marrow.

Animals↗
PubMedDate not supplied

[The detection of high-risk groups among workers in contact with heavy metals based on an analysis of chromosome aberrations and sister chromatid exchanges].

Heavy metal salts, the workers from molybdenum, tungsten and cobalt plants to make in contact with, reveal their mutagenic activity. Individual sensitivity to heavy metal salts has been analyzed through the example of molybdenum. Chromosome aberrations and sister chromatid exchanges have been studied for the regularities of their formation in lymphocytes of workers depending on the length of service. Sensitivity of tests of chromosome aberrations and sister chromatid exchanges has been compared to reveal genetic consequences of these types of the effects.

Chromosome Aberrations↗
PubMedDate not supplied

[Genotoxic effects of heavy metals and their salts in an experiment on Drosophila and mammals].

Analysis of data on the influence of different metals (cadmium, cobalt, molybdenum) on the Drosophila melanogaster cells has revealed a considerable genotoxic effect of cadmium salts which manifests in the high percentage of cells elimination at the early stages of spermatogenesis--the premeiotic cells. The modifying effect of molybdenum in the combination with cadmium and molybdenum decreasing the percentage of the progeny fall may be induced by activation of the reparation systems. In the bone marrow cells of mice Cd ions modify cytogenetic effects of the AB preparation, intensifying its mutagenic activity in some cases.

Animals↗