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Biomedical subjects

L V Devoĭno

Publications and source records attributed to L V Devoĭno.

At least 19 recordsLinked to original sources
PubMed1991

[Changes in the immune response of male mice with aggressive and submissive types of behavior].

An increase in the number of rosette- and plaque-forming cells occurred in aggressive CBA mice whereas the immune response of aggressive animals of another strain (C57BL) did not differ from control values after experiencing 10 fights. The immune response was considerably reduced in submissive C57BL mice under the same conditions. Common neuro transmitter links of the regulation of aggressive and submissive behaviour and immunomodulation, are discussed.

Aggression↗
PubMed1990

[The role of the hypophysis in the immunomodulating influence of the GABA-ergic system].

In CBA mice immunized with the sheep red blood cells (5 x 10(8)), the section of the pituitary stalk prevented the changes in the immune response caused with drugs affecting the activity of GABA-ergic system. Activating effect of the benzodiazepine receptor agonist diazepam, and inhibitory effect of bicucullin on the immune response were not manifest in animals after the lesion of the hypothalamo-pituitary stalk. The mechanism of increasing of the L3T4 T-helpers in bone marrow under the effect of GABA-ergic system activity was also actualized through the hypophysis. The central GABA-ergic mechanisms of the neuroimmunomodulation are discussed.

Animals↗
PubMed1990

[Changes in the level of dopamine and its metabolites in brain structures and immunocompetent organs in the formation of immune response].

By the method of liquid chromatography with electrochemical detection dopamine level increase was shown within 2 min after immunization of rats with sheep red blood cells in n. caudatus. In 20 min after the immune response the acceleration of dopamine metabolism was observed in nuclei A9, A10, A11, accumbens, in amygdala, hypothalamus and hippocampus. In immunocompetent organs dopamine level was changed in 24 h after the immunization.

Adrenal Glands↗
PubMed1988

[Interaction of the GABA-ergic system with the dopaminergic and serotoninergic in immunomodulation].

In CBA mice immunized with sheep red blood cells, the GABA-ergic system was found to act on the immunogenesis depending on the monoaminergic systems activity. The dopaminergic system stimulating immunogenesis is predominant in activation of the GABA-ergic system, whereas the serotoninergic system mediating the inhibition of the immune response is predominant in conditions of the GABA-ergic system blockade.

Adjuvants, Immunologic↗
PubMed1988

[Action of benzodiazepines on the immune response].

The action of benzodiazepine receptor agonists--diazepam and tazepam--on the immune response was studied in CBA mice. It has been shown that benzodiazepine at low doses of 0.5 and 1 mg/kg stimulates and at a dose of 8 mg/kg suppresses the rosette-forming reaction to immunization with 5 X 10(8) sheep red blood cells. Diazepam and tazepam fail to change the immune response if the immunization dose is 5 X 10(6). The dose-dependent effect of diazepine (ranging from stimulation to inhibition) may be caused by different benzodiazepine receptors involved in the process. It is suggested that a certain intensity of the immune response is needed for the manifestation of the immune modulating action of benzodiazepine.

Animals↗
PubMed1988

[Participation of the dopaminergic system in the immune response-stimulating effect of muramyl dipeptide].

It has been shown that administration of muramyl dipeptide (MDP) in a dose of 1 mg/kg simultaneously with SRBC (5 x 10(6) immunization resulted in a considerable increase of immune response. Stimulation of the immune response is prevented by preliminary blockade of dopamine receptors with haloperidol, that testifies to the activation of the dopaminergic system by certain MDP dosages.

Acetylmuramyl-Alanyl-Isoglutamine↗
PubMed1987

[Effect of propranolol on immunogenesis and its mode of action].

Administration of beta-blocking agent propranolol (1 or 10 mg/kg) 30 and 60 min prior to immunization with sheep red blood cells enhanced the immune response in CBA mice. The activating effect of propranolol upon immunogenesis can be characterized as peripheral since it is preserved after removal of thymus. Beta-adrenergic mechanisms do not participate in immunomodulating action of serotoninergic and dopaminergic systems.

Adjuvants, Immunologic↗
PubMed1985

[Role of the pituitary in modulating the effect of the dopaminergic and serotoninergic systems on the immune response].

Dissection of the pituitary stalk prevented the changes of the immune response caused with drugs influencing the activity of dopaminergic and serotoninergic systems. Stimulating effect of the dopamine receptor agonist--apomorphine, and inhibitory effect of blocking agent for these receptors--haloperidol on the immune response were not manifest in animals after lesion of the hypothalamo--pituitary stalk. The inhibitory action of serotoninergic system on the immunity (administration of serotonin and its precursor--5-hydroxytryptophan) was also prevented by interrupting the link between the hypothalamus and the hypophysis. The data obtained suggest central action of dopaminergic and serotoninergic systems on the immunity and indicate the important role of hypophysis in neuroimmunomodulation.

Animals↗
PubMed1982

[Distribution of functionally differing cells in immunocompetent organs on haloperidol administration].

Haloperidol blockade of the dopaminergic system entails redistribution of functionally different cells. Suppressors of IgM and IgG response migrate, respectively, from the spleen and lymph nodes to the bone marrow whose cell transfer leads to inhibition of immune response. The data obtained indicate common regularities in cell distribution under blockade of the dopaminergic and activation of serotoninergic systems. Therefore, at the basis of inhibition of immunogenesis there lie monotypic processes of suppressor cell migration whatever the system responsible for it.

Animals↗
PubMed1979

[Participation of suppressor cells in the depressing action of serotonin on immunogenesis].

The transfer of 20 x 10(6) T and B cells of lymphoid organs from the donors immunized with sheep erythrocytes and having elevated serotonin level to the recipients immunized with SRBC decreased the intensity of immune response (rosette formation and direct plaque formation). The elevation of serotonin level in the donors induced the appearance of T and B suppressors in the thymus and the bone marrow respectively and increased the population of T and B suppressors in the spleen and, to a lesser extent, in lymph nodes.

Animals↗
PubMed1979

[Rosette formation in a cell population syngeneic transfer system from donors with an altered serotinin level].

The formation of primary immune response has been studied during transplantation to sublethally irradiated recipients of cells from different immunocompetent organs of non-immune intact donors as well as of those from animals injected serotonin. Considerable variations in the development of the immune reaction have been mainly discovered due to IgM-forming cells, both during the transfer of spleen cells alone and in combined injection of these cells with bone marrow and thymus cells from the same donors. The results obtained suggest a possible serotonine influence on variations in the ratio and migration of T and B cells in different organs and on T and B suppressor cells.

Animals↗
PubMed1976

[IgM and IgG rosette formation in the primary and secondary immune response in the system of syngeneic transfer of spleen cells].

In the system of syngenous transfer of cells a study was made of the dynamics of IgM- and IgG- of the rosette-froming cells of the spleen in the primary and secondary immune response in mice of the CBA inbred strain immunized with sheep erythrocytes. It was shown that in prolongation of the interval between donor immunization and the transfer of cells to the recipient with his simultaneous immunization for up to 40 days there occurred an increase of the IgG-memory; as to IgM memory-it is expressed with shorter intervals. It is supposed that rosette-forming cells were not bearers of immunological memory.

Animals↗