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Biomedical subjects

L V Filev

Publications and source records attributed to L V Filev.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Regulation of the functional activity of the stem cell precursors of granulo- and monopoiesis by polypeptide factors of the thymus and bone marrow].

Effect of polypeptide thymic and bone marrow factors on functional activity of stem cells was studied with the use of two-layer agar system containing human bone marrow hemopoietic cells. Unlike bone marrow factor, thymic factor appreciably increased the cluster- and colony-forming abilities of cells - precursors of granulomonopoiesis. The results indicate that thymic and bone marrow factors regulate different stages of stem cell differentiation.

Bone Marrow↗
PubMed1982

[Colony-forming capacity of precursor cells of granulomonopoiesis in the liver and spleen at different stages of human embryo- and fetogenesis].

The claster- and colony-forming capacities (CFF) of cells-precursors of granulomonopoiesis (CPGM) in the livers and spleens of 37 human embryos and 9 foetuses were studied in the agar system. The CFC of CPGM in the liver and spleen of 6-8 week old embryos were higher than those during the later embryogenesis. In haemopoietic cell suspension, separated from liver cells, the CFC of CPGM were lower than in the total cell suspension from the liver of 6-8 week old embryos to constant within 6-16 weeks of embryogenesis. The discussion involves stem cell heterogeneity in human embryogenesis, a possible role of the embryonal liver in regulating the number of granulopoietic cells-precursors and their functional activity.

Clone Cells↗
PubMedDate not supplied

[Immunohematologic changes in pituitary adenomas].

The authors conducted studies of colony-producing capacity of precursor cells of bone marrow granulomonopoiesis and cytogenetic study of blood T lymphocytes in 13 patients with adenoma of the hypophysis. It was established that adenomas of the hypophysis are attended by the development of functional deficiency of T lymphocytes and the resultant disturbance of T cell regulation of granulomonopoiesis. The disorder of granulomonopoiesis occurs at the level of the precursor cells in the bone marrow.

Adenoma, Acidophil↗