PubMed Health⌕ Search

Biomedical subjects

L V Iakimenko

Publications and source records attributed to L V Iakimenko.

10 recordsLinked to original sources
PubMed2000

[Genetic studies of house mice from the hybrid area of the Primorskii Region].

Cytogenetic and allozyme differentiation of house mice Mus musculus L. was studied in 21 samples of Primorskii krai (region) from 1984 to 1998. The use of Q-H- and C-banding made it possible to reveal a high variation in the content and distribution of pericentromeric heterochromatin and high frequencies of marker autosomes 5, 7, 10, 12, 15, and 17-19 in the karyotypes of mice from some samples. The presence of marker alleles that are typical of the subspecies groups castaneus and musculus was shown for protein loci Idh, Sod-1, Aat-1, and Hbb. The data obtained indicate that the fauna of house mice of Primorye is characterized by subspecific mosaicism and hybrid origin. Apparently, subspecies M. m. castaneus, M. musculus ssp., M. M. homourus, and M. m. gansuensis contributed, to different degrees, to the formation of this fauna.

Animals↗
PubMed1988

[A rare variant of chromosome 1 in the house mouse: the presence of 2 supernumerary heterochromatin segments].

An abnormal chromosome 1 with two extra interstitial heterochromatin segments was found in the karyotype of a house mouse from the Maritime Territory. Until recently, variants of the abnormal chromosome 1 with the only extra C-block were known in house mouse of some European populations. Sizes of the abnormal chromosome 1 in a house mouse of the Maritime Territory are increased almost by 50%, in comparison with the normal homologue. C-banding showed that extra segments were localized in the area of D and F segments of the standard karyotype in house mouse, and stained homogeneously.

Animals↗
PubMed1978

[Immunologic reactivity of the body and the adrenal cortex function in the early period after administration of a carcinogen].

The level of immunological reactivity and the functional state of the adrenal cortex were studied simultaneously in BALB/c mice 7 days after a single injection of various doses of methylcholanthrene. There existed a definite correlation between the immunodepression induced by various doses of methylcholanthrene determined according to the amount of plaque-forming cells in the experimental mouse spleen and free and combined 11-corticosteroids content in the blood plasma after 7 days of the carcinogen injection. This evidence suggests that the adrenal cortex hormones play a definite role in the pathogenesis of immunodepression induced by chemical carcinogenesis.

11-Hydroxycorticosteroids↗
PubMed1978

[Effect of the removal of an induced tumor on the immunological reactivity of mice].

An extensive surgical intervention in removing a tumor-bearing limb induce in mice an enhancement of immunosuppression state, developed in the process of carcinogenesis. Rehabilitation of the immunocompetence in such mice proceeds in a more active way than in the control animals, subjected to the analogous amputation of the extremity.

Amputation, Surgical↗
PubMedDate not supplied

[Determination of nonmetabolized antipyrine in human urine].

A method for evaluating the renal clearance of antipyrine is proposed. The analyses were performed for a group of healthy females of reproductive age. The renal clearance of nontransformed antipyrine is found to be significant and the basic indices of renal activity (diuresis, creatinine excretion) are correlated with the drug concentration in saliva. A single administration of antipyrine in a dose of 10 mg/kg does not influence the renal function of healthy volunteers. The proposed photometric method of antipyrine determination in urine (under the conditions of loading with 0.5% NaCl solution at an amount of 0.5% of body weight) is sufficiently sensitive and provides information about the renal clearance of antipyrine, offering an important supplement to the data obtained by conventional methods.

Adult↗