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Biomedical subjects

L V Kitaeva

Publications and source records attributed to L V Kitaeva.

12 recordsLinked to original sources
PubMed2001

[Cellular level of the body adaptation to the environmental exposure in the large industrial city (Saint-Petersburg)].

By methods of light and electron microscopy structural disturbances of heart, kidneys, liver and pancreas were studied in rats pups who were born and kept for a year at kindergartens of city districts diverse in level of environmental pollution (air and soil). The content of micronuclei in epitheliocytes of oral mucosa in 5-6 ys old children from the kindergartens was controlled in order to detect chromosome aberrations. The examination of morphofunctional state of the organs studied and cells containing micronuclei carried out in different districts of the city allowed to reveal correlation between disorders studied and the level of environmental pollution.

Adaptation, Physiological↗
PubMed1998

[Cytogenetic aberrations in somatic cells of children living in areas with various levels of environmental pollution].

Micronuclear test was used to carry out genetic screening in somatic cells of children from different St. Petersburg districts with varying ecologic conditions. Preschool children from districts with high anthropogenic load (soil, air) revealed significant increase of epitheliocyte number in mouth mucosa. Girls appeared to be more sensitive to unfavourable environmental effects than boys. Mean values of cells with micronuclei in ecologically safe districts were 0.38 and 0.66% in pre- and school children, respectively. The study performed showed a possibility to use micronuclei count in the mouth mucosa investigating genetic effects of environmental pollution.

Adolescent↗
PubMed1996

[Genotoxic effect of formaldehyde in somatic human cells in vivo].

The genotoxic effect of formaldehyde (F) (chromosome aberrations in peripheral blood lymphocytes, micronucleated cells in buccal mucosa) was studied in workers manufacturing nitrogen fertilizer and exposed to F at concentrations exceeding maximum permissible ones for a working area (group 1); in workers at the Department of Normal Anatomy who handle moist anatomical preparations (group 2); and in students who attended anatomy lessons once (group 3). A pronounced F cytotoxic effect was found in groups 1 and 2. In lymphocytes obtained from individuals of group 1, in which frequency of chromosome aberrations exceeded the control level fourfold, metaphase plates were revealed only after 72 h of cultivation. A similar reduction of the statmokinetic index and an increase in chromosomal aberrations were observed after in vitro F treatment of lymphocytes. In groups 2 and 3, a four- to fivefold excess of micronucleated cells was found in buccal mucosa. In students, the number of micronucleated cells remained higher both 24 and 48 h after they handled moist formaline preparations in anatomy class for 40 min.

Adolescent↗
PubMed1991

[Experience with using extremely high frequency radiotherapy of the millimeter wave range in cerebrovascular disorders].

Vascular diseases of the brain (functional transient and ischemic apoplexy, circulatory encephalopathy) in 79 patients were treated by UHF electromagnetic field of millimetric wave range. 14 patients entered the control group. The treatment results are indicative of clear-cut trend to a decrease of arterial pressure, normalization of blood glucose level, arrest of DIC syndrome development.

Aged↗
PubMed1990

[The cytopathic and cytogenetic sequelae of chronic inhalational exposure to formaldehyde on female germ cells and bone marrow cells in rats].

A study was made of cytopathological and cytogenetic effects of formaldehyde chronic inhalation, in doses 0.5 and 1.5 mg/m3, on the female rat's germ and marrow cells. The harmful effect of formaldehyde on germ cells (according to the patterns of early embryogenesis) is noted under the dose 1.5 mg/m3 only, while the reliable clastogenic and cytogenetic effects on the marrow cells were revealed even in the dose 0.5 mg/m3. It is concluded that the differences between effects of small doses of formaldehyde on different cell systems were evidently caused by the specific cell dynamics of these systems.

Administration, Inhalation↗
PubMed1978

[Monosynaptic spinal reflex in epilepsy].

In 33 patients with generalized convulsive seizures a monosynaptic spinal reflex was studied. In an interattack period the author observed its clear asymmetry which was combined with a contralateral situation of epileptogenic focus on the EEG. In the majority of cases in patients with diffusive paroxysmal activity on the EEG asymmetry in the quantity of H-reflex was marked as well. The obtained data permit to recommend a study of H-reflex in an interattack period of epilepsy for specification of the topics of an epileptogenic focus.

Adolescent↗