[Some aspects of erectile dysfunction pathogenesis and treatment in patients with obesity].
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Biomedical subjects
Publications and source records attributed to L V Kondrat'eva.
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The use of various regimens of multiple insulin injections versus the regimen of a single injection resulted in more stable compensation of diabetes mellitus (glycemia stabilization), a decrease in insulin demand, smoothing over circadian glycemic variations, and correction of hypoglycemia. A choice of the number of injections and the time of administration depended on the type of a diabetic course, individual features of the patient's life style and work.
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The most informative diagnostic criteria of autoimmune thyroiditis were revealed. A kit of diagnostic tests were offered for each version of autoimmune thyroiditis. The lowest percentage of antibodies against thyroglobulin was demonstrated for the hyperthyroid hypertrophic version of autoimmune thyroiditis, while the highest for its atrophic pattern. Biopsy of the thyroid was found to be the most informative test for autoimmune thyroiditis, provided the result was positive. If the result of puncture biopsy is negative, it is desirable to apply a complex of tests depending on thyroid function and size.
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A study of TTH, T3 and T4 content in the blood serum of adolescents with juvenile thyroid enlargement showed changes which were typical of subclinical hypothyrosis. A conclusion is made about the necessity of a follow-up of children with juvenile thyroid enlargement and administration of pathogenetic therapy with thyroid hormonal drugs.
Variations in the content of acid soluble nucleotides at different growth stages of the producer of pectolytic enzymes-the fungus Sclerotinia sclerotiorum were measured. The initial growth stage was characterized by an increased content of adenyl nucleotides whose amount decreased by the 48th hour. In the 48-hour mycelium guanyl nucleoside mono- and diphosphates were the major components of the nucleotide pool. Throughout the entire cultivation cytidyl derivatives occurred in trace quantities.
The mycelium of Aspergillus foetidus was grown for 48 h, washed off, and used to study the effect of various carbon sources on the synthesis and secretion of endopolymethylgalacturonase (endo-PMG). Sucrose, glucose, glucose-6-phosphate, fructose, pectin and mannitol were shown to favour the enzyme secretion from the mycelium. The enzyme accumulation in the medium was inhibited when such inhibitors of metabolism as sodium azide and fluoride, 2,4-dinitrophenol and N,N'-dicyclohexyl carbodiimide were added, together with glucose, to the phosphate buffer. The secretion of endo-PMG from the mycelium of Aspergillus foetidus is presumed to be an energy-dependent process.