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Biomedical subjects

L V Kuznetsova

Publications and source records attributed to L V Kuznetsova.

At least 37 records · Page 2Linked to original sources
PubMed1993

[Hemodynamic changes in waking rats with acute streptozotocin diabetes after administration of the combined V2/V1 vasopressin antagonist].

The hemodynamic effect of combined V2/V1 arginine vasopressin (AVP) antagonist in conscious rats with acute 24 hour streptozotocin (STZ)--induced diabetes was studied using the microsphere technique. The rats were made diabetic with a single intravenous injection of STZ (60 mg/kg). One day after STZ administration the hemodynamic parameters in the experimental animals were measured before and 10 minutes after AVP antagonist injection (50 mg/kg, i.v.). The hemodynamic alterations observed post-antagonist included: 1) an increase in the total peripheral resistance (1.84 +/- 0.15 vs. 1.31 +/- 0.12 mm Hg/ml/min per 100 g before antagonist administration, p < 0.05), 2) a decrease in the cardiac index (49.0 +/- 3.1 vs. 68.7 +/- 5.2 ml/min/100 g before antagonist administration, p < 0.05) and stroke volume (0.40 +/- 0.03 vs. 0.57 +/- 0.06 ml before antagonist administration, p < 0.05), 3) a significant (p < 0.05) decrease in the blood flow to the skin, skeletal muscle, stomach, small intestine and kidneys. The mean arterial pressure and heart rate remained unchangeable post-antagonist. These data suggest that AVP is responsible, at least in part, for prominent hemodynamic alterations observed in conscious rats with 24 hour STZ-induced diabetes.

Acute Disease↗
PubMed1992

[Parameters of systemic hemodynamics in conscious rats with acute streptozotocin diabetes].

The effect of acute streptozotocin-induced diabetes mellitus on the systemic hemodynamic parameters was studied in conscious rats by thermodilution technique. Male Wistar rats were made diabetic with a single intravenous injection of streptozotocin (STZ, 50 mg/kg). The most important finding of this work was the elucidation of the systemic vasodilation and increased cardiac index one day after STZ injection. Such alteration in hemodynamic parameters could result in the increased blood flow and capillary hypertension in some vascular beds and, therefore, be considered as a pathogenic factor in the development of diabetic microangiopathy.

Acute Disease↗
PubMed1991

[Disordered sympathetic regulation of the functions of the cardiovascular system in rats with streptozotocin diabetes].

The effect of sympathomimetic tyramine on the systemic and regional hemodynamic parameters was studied by the radioactive microsphere technique in experiments on conscious streptozotocin-diabetic and age-matched control rats. The dose of tyramine required for blood pressure elevation on 15-20 mm Hg was 5.6 times as large in diabetic rats as compared to control animals. It was suggested that sympathetic neuropathy may play the role in the development of the cardiovascular alterations in streptozotocin-diabetic rats.

Amphetamine↗
PubMed1990

[The effect of miramistin on the phagocytic activity of the urethral neutrophilic granulocytes in patients with chronic urethroprostatitis].

It was found that addition of mirastimin to the traditional anti-inflammatory treatment results in stimulation of the absorptive capacity of the urethral phagocytes and improves the results of treatment of patients with chronic urethroprostatitis. The immunomodulator mirastimin should be given with consideration of the initial functional state of urethral neutrophilic granulocytes.

Adult↗
PubMed1990

[Effect of perinatal pathology on the morphofunctional status of the pituitary and adrenal glands in newborn infants].

A comprehensive study of the content of hormones (ACTH, STH and hydrocortisone) directly in the cells of endocrine organs (pituitary) and in the blood of the dead newborn was conducted for the first time, using immunocytochemistry and radioimmunoassays. Based on the findings obtained, the degree of maturity of adnenocorticotropic function of the pituitary was established as were adaptation reserve potentiatialities of endocrine functions in the newborn, bearing in mind the gestation age, the influence of the mother's infectious disease (chronic pyelonephritis, rheumatic fever, bronchopulmonary pathology), and the time of the child's life.

Adrenal Glands↗
PubMed1989

[Hygienic aspects of the use of liquid wastes from oil-refining and chemical plants].

It is established that utilization of pond's acid tar and n-butyl-acrylate vat residue for the binding roadway covering composition and its further application are associated with the release of a significant amount of noxious substances into the air of the work zone and inhabited areas. A set of activities, directed at the reduction of negative influence of the given technology on the sanitary state of the workplace and community air has been developed.

Acrylates↗
PubMed1987

[Adrenal glucocorticoid function and its regulation in human prenatal ontogeny and in the 1st week of life].

A comparison of cortisol and ACTH level determination in 82 human fetal sera obtained in the 11th-34th week of the intrauterine development and 50 sera from infants 1-7 days of age has revealed several stages of pituitary-adrenal system (PAS) maturation. PAS is immature in the first trimester of embryogenesis when cortisol concentration in the human fetal blood is low. The functional relations between pituitary and adrenal glands begin to establish in the middle of prenatal developmental period. A prominent response to delivery stress indicates that by delivery PAS reaches a certain stage of maturation. The feedback between ACTH and cortisol secretions in the blood of infants 1-7 days of age demonstrates that the refractory period of PAS is absent in the neonates during the first week of their life.

Adrenal Glands↗
PubMed1986

[Effect of leukocytic interferon on the functional state of bronchoalveolar phagocytes in lung diseases].

A study was made of the effect of leukocytic interferon on the phagocytic activity of alveolar macrophages and neutrophils in patients with chronic bronchitis, tuberculosis and sarcoidosis of the lungs. Cells isolated from the patients' bronchoalveolar washing off were used. It was concluded that short-term incubation of macrophages and neutrophils with interferon resulted in phagocytosis enhancement and increased intensity of metabolic processes in them. Interferon produced the most noticeable effect on cells with an initially reduced absorption capacity.

Adjuvants, Immunologic↗