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Biomedical subjects

L V Pedersen

Publications and source records attributed to L V Pedersen.

6 recordsLinked to original sources
PubMed1998

[Inhaled budesonide versus intramuscular dexamethasone in the treatment of pseudo-croup].

We randomised 59 children hospitalized for croup to treatment with either inhaled budesonide or injected dexamethasone. Group A were treated with two inhalations of 1000 micrograms budesonide and group B received dexamethasone 0.6 mg/kg intramuscularly. We used a modified Westley-score, based on chest-wall retractions, barking cough, respiratory frequency and stridor. The children was aged three months to six years (mean 20 months). Three hours after the first treatment there was significant improvement in score amongst all children (p < 0.001), but no difference between the two groups (p < 0.20). Six and 12 hours after the first treatment there were significantly better clinical scores in group B (p = 0.001, p = 0.0004). Based on this study we recommend dexamethasone 0.6 mg/kg intramuscularly for children to be treated for croup.

Administration, Inhalation↗
PubMed1996

[UL-scanning of children with recurrent abdominal pain--a diagnostic gain?].

The medical records were reviewed for 109 children (0-15 years) who were investigated by abdominal ultrasonography as part of the evaluation of recurrent abdominal pain. We characterised this group of children in an attempt to localise the characteristics that would predict abnormal findings by abdominal ultrasonography. We conclude that neither location, frequency or duration of pain, nor sex nor age have any predictive value. All abnormal findings seen by abdominal ultrasonography could have been revealed by a carefully taken history, thorough clinical examination and commonly performed laboratory tests, such as urine analysis. We recommend that abdominal ultrasonography should only be used in the evaluation of recurrent abdominal pain in children if there are other characteristics, such as a history of cystitis.

Abdominal Pain↗
PubMed1995

[Thyroid involvement in systemic lupus erythematosus].

Systemic lupus erythematosus (SLE) is a rare disease in childhood, and is characterized by widespread inflammation of blood vessels and connective tissue. Although the disease affects a number of different organs, thyroid involvement is not included in the classification criteria set of SLE. We describe two cases of irls with SLE who developed thyroiditis with goitre, thyroid autoantibodies, elevated serum TSH and decreased thyroid function tests. One patient had thyroiditis eighteen months before SLE was diagnosed and the other developed thyroiditis six months after the onset of SLE. Recent prospective studies have shown that thyroid involvement in SLE presenting either as hyper- or hypothyroidism is more common among children than adults. We therefore recommend that thyroid function tests should regularly be performed in juvenile SLE patients and, conversely, that child patients with Hashimoto's thyroiditis should be examined for symptoms and serology of SLE.

Adolescent↗
PubMed1991

[Diagnosis and treatment of ear diseases in general practice. A controlled trial of the effect of the introduction of middle ear measurement (tympanometry)].

The diagnosis and treatment of diseases of the ear in general practice could be rendered optimal by employing tympanometry (measurement of the pressure in the middle ear) which is already known from specialist practice. This was investigated by means of a controlled investigation with cooperation between general practice, otologists and the health services in the County of Vejle. Following randomizing among 20 general practitioners, ten were trained in tympanometry (the test group) while ten did not change their principles for diagnosis and treatment (control group). The criteria for inclusion in the investigation were the findings of indications for otoscopy in children under the age of 16 years. During a period of 12 months, parallel registrations of the data were made in the two groups and 3,166 children with an average age of 3.4 years were included. The clinical course showed statistically significant differences (p less than 0.05) between the groups as regards diagnosis and treatment: acute otitis media was found in 8.4% in the control group and 2.6% in the test group. Secretory otitis media (glue ear) was found in 14.2% in the control group and in 25% in the test group. Correspondingly, penicillin was prescribed for 7.6% in the control group and 4.1% in the test group. The otologists performed tubulation of the tympanic membrane in 0.9% in the control group and 3.2% in the test group. Continued investigations are necessary to elucidate whether tympanometry should be part of the daily routine in general practice.

Acoustic Impedance Tests↗