Biomedical subjects
Publications and source records attributed to L V Stepanova.
The direction of fluid flow in rabbits was studied in vivo by the distribution of fluorescein in eye structures. Fluorescein was administered into the central part of the lens. Fluorescein migrated from the anterior to posterior surface of the lens and then appeared in the vitreous body. Fluorescein did not migrate to the anterior surface and did not appear in the anterior chamber of the eye.
AIM: To examine anti-inflammatory effect of statins on outcomes of acute coronary syndrome (ACS). MATERIAL AND METHODS: The trial included 211 ACS patients without ST elevation at ECG. The patients were followed up for 180 days. The anti-inflammatory action was studied for 30 days. The patients were divided into two groups by the treatment: simvastatin 10 mg + aspirin 325 mg (104 patients, group 1) and simvastatin 40 mg + aspirin 325 mg (107 patients, group 2) for 30 days. RESULTS: Simvastatin in maximal dose lowed LDLP cholesterol from 101 +/- 9.8 to 72 +/- 3.3 mg/dl, in a minimal dose--from 104 +/- 11.3 to 81 +/- 2.1 mg/dl (p < 0.05). Only maximal dose simvastatin produced a significant reduction of C-reactive protein (CRP) to the disease day 14. The integral index including all cases of cardiovascular death +acute myocardial infarction+progressive angina+rehospitalization was 70 scores for group 1 and 137 for group 2 (p = 0.047). CONCLUSION: Use of simvastatin in ACS patients, initially normal level of LDLP cholesterol and elevated level of CRP produced a dose-dependent effect, alleviated inflammation and improved the disease course.
A comparative retrospective study was made to examine influence of replacement therapy by estradiol valeriate and climonorm on perimenopausal hypertension. The test group (25 hypertensive women) received climonorm for 6 months. Control women received hypotensive therapy. Lipid metabolism and risk of vascular events were assessed. The replacement therapy had a positive effect on lipid metabolism. Criteria of Mann-Whitney, Friedmann, Wilkinson and of chi 2 were made use of. The target arterial pressure was achieved only with hypotensive therapy which also diminished intensity of menopausal disorders. To determine individual policy, it is necessary to stratify risk of cardiovascular events. The best effect is achieved at combination of hypotensive therapy with replacement hormone treatment.
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Examination of the Harderian gland structure of the Black Sea bottlenose dolphin, Tursiops truncatus ponticus, at macroscopic, microscopic, and electron microscopic levels shows significant sexual dimorphism. The epithelial cells of male and female glands are different cell types, capable of producing chemically different products. Secretory cells in both sexes contain secretion granules that produce a secretion consisting mainly of proteins and carbohydrates, but thought to be sex-specific in composition. The female glands also contain lipid secretion granules. It is suggested that in the bottlenose dolphin the Harderian gland functions to produce sexually distinct pheromones and may have other physiological activities, e.g., participating in local immunological or endocrine-related reactions.
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Literature data and the authors' results, concerning structural and functional peculiarities of all varieties of the cerebral neuroglia under effect of a cranial-cerebral trauma, neurotropic chemical products and oxygen insufficiency have been considered. Ideas that neuroglial reactions under the conditions mentioned are proved to be constant and in dependence of certain peculiarities of each case are either progressive or regressive. The reaction degree is mainly proportional to the disturbance power. Nevertheless, certain discrepancies (ariactivity including) can be observed; this is also determined by a combination of prerequisites and by a peculiarity of individual reactivity of the CNS. The greatest stability of astroglia has been stated. Possible variations in relation between changes of neurons and gliocytes are mentioned. Suggestions are made that diffuse-focal progressive reactions of macroglia under conditions of neurotoxicoses can be determined not by proliferation of cells, but by their migration.
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Both the increasing and decreasing contents of vitamin A in rats induced a lowering of cell adhesion in the skin multilayer epithelium, and that of their packing density. However, the same stimulus did not alter cell adhesion in the small intestinal monolayer epithelium. The data obtained show that vitamin A may serve as a factor modulating intercellular adhesive interactions with tissue specificity.
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