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Biomedical subjects

L Vakov

Publications and source records attributed to L Vakov.

At least 19 recordsLinked to original sources
PubMed1987

[Basal blood level of thyroxine in diabetes mellitus patients].

An insignificant lower mean blood level of T4 in diabetics versus healthy subjects was established on the base of the studies performed to 136 patients with diabetes mellitus. The slight tendency to decrease of T4 showed no dependence on sex, age, light bi-directional deviations from the standard body mass, duration and type of diabetes and differences in the drug treatment. The dependence between glycemia and blood thyroxine is poor. The lower level of blood thyroxine in the patients with nephropathy is very likely, a sequela of the existing nephropathy. A tendency to normalization of T4 blood level was observed with the compensation of diabetes.

Adult↗
PubMed1987

[Comparative research on the basal blood level of contrainsular hormones in diabetics with compensated and subcompensated nephropathy].

The blood levels of II contrainsular hormones were studied in patients with diabetes mellitus, with compensated and subcompensated nephropathy. No significant difference in both subgroups was established in any of the hormones. Those data suggest that the changes, established by us, in the blood levels of the hormones studied resulted from the changes in their secretion, and not from the changes in their renal elimination due to the existing light renal insufficiency in some of them. On the other hand, the existing light renal insufficiency in the diabetics should not be the reason for avoiding examinations and reserve to the results obtained from the hormonal dosage, when it is necessary.

Diabetic Nephropathies↗
PubMed1986

[Effect of compensation on the basal blood level of contrainsular hormones in diabetics].

The effect of the compensation of diabetes on the basal level of II contrainsular hormones was studied. Some of the hormonal deviations were completely normalized with the compensation of the diabetes, another part showed values closer to those of the healthy, and only a quarter of the hormones studied--showed no essential dynamics in their levels. The tendency to normalization of the established hormonal changes was more distinct in case of more accurately selected criteria of compensation, justifying the effort at optimal compensation of diabetes. The results obtained suggested that the hormonal deviations had a reactive character.

Blood Glucose↗
PubMed1986

[Comparative studies on the basal blood levels of contrainsular hormones in diabetics with and without retinopathy].

Comparative studies on the basal blood level of II contrainsular hormones have been carried out in patients with diabetes mellitus in subgroups with present, absent resp. retinopathy. The presence of diabetic retinopathy was established to be accompanied by the reduction of T3 and serotonin, whereas its absence was accompanied with the increase of TTH. The elucidation of the significance of the hormonal discrepancies established for the pathogenesis of retinopathy requires additional studies.

Diabetes Mellitus↗
PubMed1986

[Interrelations of blood levels of contrainsular hormones and titers of insulin antibodies in diabetics treated with insulin].

According to literature data, the hormones are one of the factors, affecting immunogenesis. On the other hand, the factors and mechanisms, related to insulin-antibody formation, are not sufficiently elucidated in diabetics, insulin-treated. The relationships between the changes of a broad spectrum of contrainsular hormones and those of immunoglobulins were studied in that aspect. A low correlation relationship was established between them.

Delayed-Action Preparations↗
PubMed1985

[Relation between blood levels of immunoglobulins A, M and G and anti-insulin hormones in diabetics].

Changes in immunoglobulins and secretion of contrainsular hormones were established in patients with diabetes mellitus according to literature data as well as on the base of the author's own material. On the other hand, the hormones are one of the factors with an influence on immunogenesis. With a view to that fact, the interrelations between them were, for the first time, studied in diabetics. A low correlation dependence was established between the indices studied.

Adrenocorticotropic Hormone↗
PubMed1985

[Urinary catecholamines in normal-weight and overweight diabetics].

The 24-h urine excretion of free, conjugated and total fraction of Dopa, dopamine, noradrenaline and adrenaline was studied in diabetics with normal weight and overweight. A tendency to lower excretion of adrenaline, noradrenaline and dopamine was established in diabetics with overweight as well as a tendency to reverse correlation between overweight and urine excretion of catecholamines. On the base of the so called synthesis and degradation coefficients, the possibility the changes established in the diabetics with overweight to be due to reduced synthesis of dopamine and noradrenaline is discussed. A presumption is presented about the possible causative relation between the reduction of catecholamine excretion and overweight in diabetics.

Body Weight↗
PubMed1985

[Immunoglobulins and diabetic microangiopathy].

Blood level of immunoglobulins A, M and G were studied in 166 diabetics with present or absent microangiopathy. Regardless of the significant elevation of IgA and IgG, for the whole group, reduction of IgM respectively, no significant difference was established in their level among the subgroup with present or absent retino- and nephropathy as well as among those with proliferative and non-proliferative retinopathy.

Chronic Disease↗
PubMed1984

[Circadian rhythm of cortisol secretion in diabetes mellitus patients].

The circadian rhythm of cortisol secretion was studied in 46 patients with diabetes mellitus. According to the complex criteria the rhythm was lost in 41 per cent of the examined. The rhythm changes do not depend on sex, blood sugar level, type of diabetes, vascular degenerative complications. A tendency was observed of reduction of the difference between the morning and evening cortisolemia with the advancement of the disease. The results obtained suggest a disorder in the functional integrity between hypothalamus and hypophyseal-suprarenal axis in a considerable part of the diabetics.

Blood Glucose↗
PubMed1984

[Excretion of free and bound catecholamines in the urine of diabetes mellitus patients].

The 24-h excretion of free, conjugated and total fractions of dopa, dopamine, noradrenaline and adrenaline was studied in 32 patients with diabetes mellitus. Adrenaline and dopamine were established to be increased--dopa decreased and noradrenaline--not changed. An attempt is made to explain the hormonal changes on the base of the analysis of the so called synthetic and dissociative coefficients of catecholamines. A moderate reverse correlation of the changes with the age of the patients and duration of diabetes was established as well as lower values in the female-diabetics versus the male-diabetics. The hormonal deviations are associated with the disturbances in the carbohydrate metabolism, have a reactive character and are manifested in insulin-dependent type of diabetes.

Aging↗
PubMed1984

[Urinary excretion of free cortisol in diabetics].

The 24-h urine excretion of free cortisol was studied of 61 patients with diabetes mellitus. Its average value is significantly higher than that of healthy controls. No correlation was established between those changes and sex, age, light overweight in some of the patients, duration and type of diabetes as well as of vascular-degenerative lesions. A positive correlation was established between cortisoluria and glucosuria as well as significantly lower excretion of cortisol in the compensated versus decompensated diabetics, suggesting that the changes established are of reactive character.

Adult↗
PubMed1984

[Basal blood level of serotonin in diabetes mellitus patients].

Blood serotonin was determined in 184 patients with diabetes mellitus by a biological method. Its average value in diabetics was significantly lower than that of the control healthy subjects. The changes established show a light dependence on sex and age of the patients, duration and type of the disease, blood sugar level and the kind of drug treatment. They are better manifested in the presence of retinopathy versus in its absence, as well as in the presence of proliferative versus non-proliferative one. With the compensation of the diabetes, a tendency to partial normalization of serotonin blood level was observed. The probable causes of serotonin changes established are discussed.

Adult↗
PubMed1984

[Basal blood level of thyrotropic hormone in diabetes mellitus patients].

The basal blood level of the thyrotropic hormone (TTH) was radioimmunologically determined in 160 patients with diabetes mellitus. A significant increase of its average level was established versus that in the control group of healthy subjects. The changes found showed no dependence on sex, age, duration and type of disease, light deviations from the standard body weight and the differences in drug treatment. A light correlation was established between the thyrotropinemia and glycemia as well as an insignificant dynamics of the hormonal blood level after the compensation of the diabetes. The higher TTH level established in the patients without retinopathy requires further studies on the significance of that fact.

Adult↗
PubMed1981

[Somatotropic hormone in the serum of diabetics].

The results from the studies on basic values of somatotropic hormone (STH) in 142 patients with diabetes mellitus are reported. No linear dependence was found between blood sugar and STH level in serum in the morning before meals. As compared with the subjects from a control group, STH in serum of diabetics without retinopathy, with retinopathy, with obesity and renal insufficiency resulting from nephropathy was increased with a statistical significance. STH values in serum of patients without microangiopathies were lower than those in patients with manifested retinopathy and higher than those in patients with obesity, the difference being not statistically significant. The serum level of somatotropic hormone in patients with manifested renal insufficiency was higher, with statistical significance, than that of patients without renal insufficiency.

Adolescent↗