Apoptosis in prostate cancer after hormonal treatment.
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Biomedical subjects
Publications and source records attributed to L Vass.
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The operated and cured case of fibrous histiocytoma, a retroperitoneal tumour of rare histological structure, unusual localization and size is reported.
Patients with malignant parotid tumors were treated at two different centres with slightly ionizing radiation (110 patients) and neutron therapy (15 patients). The treatment results are compared. The principles of comparison applied in this analysis are identical. The histologic classification was made according to the W.H.O. recommendation of 1972 and the staging according to Becske. Local tumor control is the criterion applied in the comparative assessment of both methods. The analysis has shown that there is no significant difference in the treatment results within the individual stages of tumor's advancement after application of an orthovolt therapy and a telecobalt therapy. Patients treated in early stages (stages I and III) had a substantially higher rate of local tumor control (72%) than patients in advanced stages (46%, stages III and IV). A more favorable treatment results was achieved by neutron therapy in all stages of tumor's advancement. In this case the rate of patients with local tumor control (87%) was significantly higher than after radiotherapy with slightly ionizing radiation (46%).
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Brilliantly fluorescent supernumerary chromocenters indistinguishable from the Y-chromatin have been often found electively in the thyroid nuclei. The authors compared the occurrence of this Y-chromatin-like fluorescence in 31 thyroid adenomas obtained from 30 autopsy cases (10 males, 20 females) with non-adenomatous thyroid tissues of the same cases. All adenomas had follicular structure but one with papillary structure. The frequency class of Y-chromatin-like fluorescence of adenomas was lower in 15 cases out of 31 than that of the same non-adenomatous thyroid tissue. The Y-chromatin-like fluorescence had a negative count in 13 cases of 31 adenomas but only in 3 cases of normal thyroid tissues from 30 persons. The disappearance of the nuclei with Y-chromatin-like chromocenters is supposedly connected with cellular dedifferentiation of thyroid adenomas.
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Non-random distribution of fluorescing chromatin bodies resembling Y chromatin was observed among the cell populations of various organs obtained by autopsy of 52 adults. This type of Y-chromatin-like fluorescence is more frequent in thyroid and brain than in other organs. The Y-chromatin-like bodies of thyroid nuclei are not closely correlated with the brilliantly fluorescing autosomal blocks of lymphocyte mitoses of the same persons, as it was demonstrated in surgical cases.
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