Biomedical subjects
L Von Koch
Publications and source records attributed to L Von Koch.
Alteration in the distribution of organ perfusion following profound hypothermia and circulatory arrest in the baboon.
The physiologic consequences of profound hypothermic circulatory arrest in infants are incompletely understood. Immature baboons underwent surface cooling, followed by core cooling using cardiopulmonary bypass, circulatory arrest for 30 min, and perfusion rewarming. Blood flow to and within organs was studied using the multiple-radionuclide-label microsphere technique. Marked redistribution of total and regional myocardial and cerebral flow occurred during cooling and rewarming.
Reconstruction of failed aortofemoral or femoropopliteal grafts.
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A practical method of autotransfusion in the emergency center.
A new mobile autotransfusion device, modified for use in the Emergency Center, is described. Preliminary usage in thirty trauma patients who underwent autotransfusion of 60 units of blood indicated the device was simple to utilize, efficacious, inexpensive, cost-effective, and safe.
Successful repair of a right coronary artery-coronary sinus fistula with associated left coronary arteriosclerosis.
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Oxidized orlon as a blood interface.
Polyacrylonitrile fabric (Orlon) may by oxidized by heating in air, when it becomes black and carbonized. During the heat treatment, the fibers shrink; this shrinkage allows components such as diaphrams to be shaped around molds. Oxidation reduces the tensile strength by about 25% and also reduces the stiffness of the material. The oxidized Orlons was screened in tissue culture for possible cytotoxic effects. Finding none, patches of the material were sutured into the right atrium of dogs and examined after 48 hr. Because of encouraging results, 10 atrial patches, consisting of Dacron velour and oxidized Orlon side-by-side, were implanted into the right atrium of dogs. Five patches were backed with Silastic to render them impervious, and five with segmented polyurethane. The atrial patches were examined after 48 hr, and in all instances the oxidized Orlon part of the patch was coated with a thinner and smoother fibrin layer than was the Dacron velour half. a left ventricular bypass pump was fabricated from oxidized Orlon and spray-coated on the nonblood surface with segmented polyurethane. After 48 hr implantation in the chest cavity of a calf, pumping without systemic anticoagulation, the pump was found covered by a thin, smooth, firmly attached layer of fibrin.
Aneurysm of the sinus of Valsalva producing obstruction of the left main coronary artery.
An aneurysm of the left sinus of Valsalva compressed the left main coronary artery and the patient experienced anginal pain. Surgical correction consisted of obliteration of the orifice of the aneurysm, aortic valve replacement, and a saphenous vein bypass from the ascending aorta to the distal left anterior descending coronary artery. Postoperative studies revealed excellent function of the prosthetic valve, no recurrence of the aneurysm and retrograde filling of the left anterior descending and circumflex coronary arteries. Three years after the operation, the patient is asymptomatic.
A reproducible model of left ventricular failure in the closed-chest, anesthetized dog.
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