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Biomedical subjects

L W LAW

Publications and source records attributed to L W LAW.

At least 19 recordsLinked to original sources
PubMed1965

THYMUS: ROLE IN RESISTANCE TO POLYOMA VIRUS ONCOGENESIS.

Mice of the C57BL strain are highly resistant to the oncogenic property of LID-1 polyoma virus, but complete thymectomy within 24 hours of birth rendered these mice susceptible. In thymectomized mice inoculated with adult syngeneic spleen cells, the capacity to resist oncogenesis was restored. The results add further weight to the concept that induction and progression of tumors by polyoma virus has an immunologic basis.

Animals↗
PubMed1964

HUMORAL THYMIC FACTOR IN MICE: FURTHER EVIDENCE.

Mice of the C3H and DBA strains thymectomized at birth showed a consistent and striking suppression of antibody production (hemolysin response) to sheep erythrocytes. When cell-tight Millipore diffusion chambers containing syngeneic thymic tissue were implanted intraperitoneally, the capacity of these neonatally thymectomized mice to respond to this antigen was restored. The pattern of response and the mean titer were similar to the pattern and mean titer observed in neonatally thymectomized mice bearing subcutaneous grafts of syngeneic thymic tissue. These data are consistent with the concept that thymic tissue within the chamber produced a specific diffusible factor that enabled the thymectomized animal to establish immunologic competence.

Animals↗