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Biomedical subjects

L W Lu

Publications and source records attributed to L W Lu.

10 recordsLinked to original sources

Pseudotumor cerebri: an observation and review.

In five consecutive cases of pseudotumor cerebri we observed an elevation in the erythrocyte sedimentation rate that we were able to correlate with the changes in the degree of papilledema. In spite of an extensive medical workup, no other cause for the increased ESR was found. Our findings suggest that possibly serial ESR determinations might be of assistance in following cases of pseudotumor cerebri.

Adult↗

Eales' disease: a case of rapid progression.

A case of bilateral vitreous hemorrhage is presented in a young black man. Work-up showed the patient to have Hb AA with a markedly positive PPD and a negative chest roentgenogram. A diagnosis of periphlebitis retinae or so-called Eales' disease was made. This case was remarkable in its speed of progression and the severity of the disease process. This case calls attention to the importance of rapid diagnosis and evaluation for possible treatment.

Adult↗

Effects of 5-fluorouridine on modified nucleosides in mouse liver transfer RNA.

Administration of the pyrimidine antimetabolite, 5-fluorouridine, to mice was found to cause a marked specific reduction of the amounts of 5-methyluridine, pseudouridine, and dihydrouridine but not of 3-(3-amino-3-carboxypropyl)uridine in tRNA from the livers of the treated animals. The data presented indicate that this effect is not simply due to the incorporation of 5-fluorouridine into tRNA; the drug appears to interfere directly with the enzymic reactions involved in the modification of the 5-position of uridine. 5-Fluorouridine was found to have no effect on the modification of adenosine, guanosine, and cytidine in mouse liver tRNA.

Animals↗

Effects of DL-ethionine on mouse liver tRNA base composition.

Treatment of mice with DL-ethionine and adenine causes a reduction of all methylated bases of liver tRNA. This effect is dose-dependent and specific for the methylated bases. Individual methylated components are affected to different extents, m22G being most sensitive to inhibition.

Adenine↗

Primary congenital eversion of the upper lids.

A case of bilateral primary congenital eversion of lids in a newborn black male is described. It is a self-limiting disease and does not leave any sequelae. A higher incidence in black infants has been noted in the literature.

Adult↗