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Biomedical subjects

L W Lyon

Publications and source records attributed to L W Lyon.

12 recordsLinked to original sources
PubMed1981

Subacute arsenic neuropathy: clinical and electrophysiological observations.

Two patients with subacute arsenic neuropathy are described and the results of serial conduction velocity determinations from the very early stages of the illness to partial recovery are reported. Sensory and motor deficits were maximal within four weeks of the estimated time of exposure. Recovery was slow, with only partial improvement of the neurological deficits two years after onset of the illness. Progressive slowing of motor conduction velocity was observed in the first three months followed by a gradual increase in velocity thereafter. The possible mechanisms underlying the temporal profile of the electrophysiological changes are considered. The need for initiating chelation therapy before the development of the neuropathy is emphasised.

Arsenic Poisoning↗
PubMed1972

Orbicularis oculi reflex in the Wallenberg syndrome: alteration of the late reflex by lesions of the spinal tract and nucleus of the trigeminal nerve.

The orbicularis oculi reflex was studied in nine cases with lateral medullary lesions. Diagnosis of the Wallenberg syndrome was made clinically in seven cases and at necropsy in another. The clinical features of one other case were closely allied to but not typical of this syndrome. An afferent delay of the late reflex on the side of the lesion in the presence of a normal early reflex was seen in all but two cases. In one of the latter, the late reflex was normal and in the other, a comatose patient, the late reflex was totally absent. It was concluded that the neurones of the first order responsible for the bilateral late reflex on unilateral stimulation terminate in the ipsilateral spinal nucleus of the trigeminal nerve without significant crossing over to the same structure on the other side. An afferent delay of the late reflex in the presence of a normal or nearly normal early reflex is consistent with a lateral medullary lesion implicating the spinal tract and nucleus. The Wallenberg syndrome is a common clinical entity showing this abnormality of the orbicularis oculi reflex.

Adult↗
PubMed1972

Orbicularis oculi reflex in coma: clinical, electrophysiological, and pathological correlations.

The orbicularis oculi reflex was studied in 48 comatose patients and the results were correlated with clinical and pathological findings. The late component of the reflex was absent or of minimal amplitude in all cases regardless of the site of lesions, reflecting a diffuse suppression of the reticular system rather than a specific or local block in the brain-stem. Alteration of the early component of the reflex, on the other hand, generally indicated primary or secondary structural changes in the pons, although reversible functional or pharmacological block of pontine conduction was also documented.

Brain Diseases↗