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Biomedical subjects

L W Mason

Publications and source records attributed to L W Mason.

4 recordsLinked to original sources

Evaluation of multimodal treatment program for fibromyalgia.

A quasi-experimental design was used to assess a multimodal pain treatment program for female patients with fibromyalgia to ascertain immediate and long-term effects. Laboratory and self-report pain measures together with psychological measures were obtained from patients who were tested up to 6 months after treatment. Comparison data were also obtained from fibromyalgia patients who failed to qualify for the treatment program because of insurance coverage. Immediate and long-term treatment effects were evident with the psychological measures and the subjective pain measures but not with the laboratory pain measures. Participants who attended the month-long multimodal program achieved significant and positive changes on most of the outcome measures. However, relapse prevention must be addressed.

Activities of Daily Living↗

Photodynamic assay of light distributions in tissue phantoms.

The distribution of light in tissues of varying blood content has been modeled using a gel agar system as a tissue phantom. Hematoporphyrin derivative (Photofrin I or HpD) was suspended in gels, along with a chemical indicator of its cytotoxic intermediate (singlet oxygen), and various amounts of red blood cells. The singlet oxygen detector used was tryptophan and its oxidation product. Qualitative analysis of the tryptophan photoproduct was determined using high-pressure liquid chromatography analysis of individual gel sections. The relative amount of photoproduct was used as a measure of the fluence of actinic light at a given depth within the tissue phantoms. In this manner, the relative activation efficiencies of HpD were determined for light from an argon laser (mainly 488 and 514.5 nm) and an argon-pumped dye laser (630 nm).

Hematoporphyrin Derivative↗