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Biomedical subjects

L W Townsend

Publications and source records attributed to L W Townsend.

15 recordsLinked to original sources

Risk analyses for the solar particle events of August through December 1989.

The solar particle events of August through December 1989, among the largest ever recorded, are analyzed to assess the potential hazards to humans on interplanetary missions from events of these types. Using the coupled neutron-proton space radiation transport computer code, BRYNTRN, risk estimates for the effects of exposures to the skin, ocular lens, and bone marrow are made for nominal thicknesses of the spacecraft aluminum shielding. Risk assessment in terms of absorbed dose is made for each event. Also presented are estimates of organ absorbed dose and dose equivalent for pairs of events which occurred within 30-day periods, and for the cumulative August through December 1989 period.

Elementary Particles

Interplanetary crew exposure estimates for galactic cosmic rays.

Using the Langley Research Center galactic cosmic-ray transport computer code and the Computerized Anatomical Man model, initial estimates of interplanetary exposure of astronauts to galactic cosmic rays, during periods of solar minimum activity, are made for a realistic human geometry shielded by various thickness of spacecraft aluminum shielding. Conventional dose assessment in terms of total absorbed dose and dose equivalent is made for the skin, ocular lens, and bone marrow. Included in the analyses are separate evaluations of the contributions from the incident primary ions, from subsequent-generation fragmentation products, and from target fragments. In all cases considered, the equivalent sphere approximation yielded conservative overestimates for the actual organ exposures.

Cosmic Radiation

Biological effectiveness of high-energy protons: target fragmentation.

High-energy protons traversing tissue produce local sources of high-linear-energy-transfer (LET) ions through nuclear fragmentation. We examine the contribution of these target fragments to the biological effectiveness of high-energy protons using the cellular track model. The effects of secondary ions are treated in terms of the production collision density using energy-dependent parameters from a high-energy fragmentation model. Calculations for mammalian cell cultures show that at high dose, at which intertrack effects become important, protons deliver damage similar to that produced by gamma rays, and with fragmentation the relative biological effectiveness (RBE) of protons increases moderately from unity. At low dose, where sublethal damage is unimportant, the contribution from target fragments dominates, causing the proton effectiveness to be very different from that of gamma rays with a strongly fluence-dependent RBE. At high energies, the nuclear fragmentation cross sections become independent of energy. This leads to a plateau in the proton single-particle-action cross section, below 1 keV/micron, since the target fragments dominate.

Cell Survival

Interplanetary crew exposure estimates for the August 1972 and October 1989 solar particle events.

Using the coupled neutron-proton space radiation transport computer code (BRYNTRN), estimates of human exposure in interplanetary space, behind various thicknesses of aluminum shielding, are made for the large solar proton events of August 1972 and October 1989. A comparison of risk assessment in terms of total absorbed dose for each event is made for the skin, ocular lens, and bone marrow. Overall, the doses associated with the August 1972 event were higher than those with the October 1989 event and appear to be more limiting when compared with current guidelines for dose limits for missions in low Earth orbit and more hazardous with regard to potential acute effects on these organs. Both events could be life-threatening if adequate shielding is not provided.

Bone Marrow

A closed-form solution to HZE propagation.

An analytic solution for high-energy heavy ion transport assuming straight-ahead and velocity-conserving interactions with constant nuclear cross-reactions is given in terms of a Green's function. The series solution for the Green's function is rapidly convergent for most practical applications. The Green's function technique can be applied with equal success to laboratory beams as well as to galactic cosmic rays allowing laboratory validation of the resultant space shielding code.

Cosmic Radiation

An evaluation of energy-independent heavy ion transport coefficient approximations.

Using a one-dimensional transport theory for laboratory heavy ion propagation, evaluations of typical energy-independent transport coefficient approximations are made by comparing theoretical depth-dose predictions to published experimental values for incident 670 MeV/nucleon 20Ne beams in water. Results are presented for cases where the input nuclear absorption cross sections, or input fragmentation parameters, or both, are fixed.

Cosmic Radiation

Preliminary observations on clinical use of a base metal casting alloy.

A study was conducted to develop a laboratory technique and to evaluate the clinical efficacy of a base metal casting alloy. Slight modification of recommended investing procedures is required to produce consistently well-fitting castings with the test alloy. After 12 months of clinical service, the test alloy did not differ from the control alloy in tarnish, untoward gingival response, resistance to abrasion, or tooth sensitivity.

Chemical Phenomena

Soldering nonnoble alloys.

Successful presoldering of nonnoble alloys is variable at best. Under controlled conditions of joint gap distance, investing, and soldering, more than one third of the soldered joints are likely to fail. Furthermore, the recorded strength of successful solder joints was inconsistent. Improved heat application and controlled oxidation are required. Until new materials and/or techniques are developed, the soldering of nonnoble alloys prior to the application of porcelain is unwarranted.

Dental Alloys