PubMed Health⌕ Search

Biomedical subjects

L Warneke

Publications and source records attributed to L Warneke.

15 recordsLinked to original sources
PubMed1999

Obsessive-compulsive disorder in schizophrenia: epidemiologic and biologic overlap.

OBJECTIVE: To examine the co-existence of obsessive-compulsive disorder (OCD) with schizophrenia in terms of epidemiology and overlapping biologic substrates. METHODS: Review of the relevant literature. RESULTS: There appears to be a significant prevalence of OCD in schizophrenia--higher than what would be expected on the basis of calculated comorbidity figures. There is significant overlap in the proposed functional circuits of OCD and schizophrenia, which may lead to co-expression of symptoms. Although there is overlap in neurotransmitter dysfunction, the interactions are complex, especially in regard to the serotonin and dopamine systems. CONCLUSION: The expression of OCD in schizophrenia is complex but very intriguing. Theoretical hypotheses of the pathology of the 2 disorders now need to be tested in larger controlled trials.

Brain↗
PubMed1996

Management of resistant depression.

Treatment-resistant depression is a relative concept. It has been formally defined as a mood disorder that fails to respond to three adequate trials of antidepressants. However, treatment resistance is relative to the expertise and knowledge of the treating physician and the availability of resources, such as electroconvulsive therapy. Only about 7% of patients show absolute treatment resistance, and even they can be helped.

Antidepressive Agents↗
PubMed1993

Anxiety disorders. Focus on obsessive-compulsive disorder.

Obsessive-compulsive disorder was once thought to be rare. Recent epidemiologic surveys reveal the lifetime prevalence rate to be as high as 3%. We now have greater understanding of the neurophysiologic and neurochemical basis of this very crippling disorder. Although obsessive-compulsive disorder often starts in adolescence or early adulthood and can last a lifetime, effective treatment enables most patients to lead relatively normal lives.

Adolescent↗
PubMed1993

Managing resistant depression. When patients do not respond to therapy.

Many factors can influence outcome in the management of depressive illness, a major public health problem with significant associated mortality and morbidity. Two-thirds of patients will respond to antidepressants. The remainder can be treated in other ways. Only about 7% of patients are absolutely treatment resistant, and even they can be helped.

Antidepressive Agents↗
PubMed1990

Psychostimulants in psychiatry.

The use of the psychostimulants in psychiatry is reviewed. A brief historical perspective on dextroamphetamine is presented, and a brief review of the psychopharmacology of dextroamphetamine, methylphenidate and magnesium pemoline is given. The literature on the use of stimulants in the treatment of resistant depression, apathetic geriatric patients and patients medically ill with a secondary depression is summarized and two case histories given to illustrate the clinical usefulness of the stimulants. The literature on the use of stimulants as an adjunct to antidepressant therapy and as a diagnostic test is also discussed. Finally the use of stimulants in obsessional illness and adult attention deficit disorder is summarized. The writer concludes by commenting that the stimulants have a very useful role in the treatment of certain categories of depression as well as other psychiatric syndromes and such patients should not be deprived of symptom relief by these drugs. The approach to therapy should be much the same as the use of analgesics for chronic pain sufferers.

Adult↗
PubMed1989

Intravenous chlorimipramine therapy in obsessive-compulsive disorder.

A brief summary of the etiological factors and pharmacological approaches to therapy of obsessive-compulsive disorder is given. Evidence for the serotonergic hypothesis is reviewed. Three case reports of patients with severe OCD who had not responded to traditional chemotherapeutic approaches and electroconvulsive therapy are presented. All three responded to a series of 14 intravenous chlorimipramine infusions with a maximum dose of 350 mgms per infusion. The technique of infusion therapy and possible mechanisms of action are discussed. It is concluded that OCD is no longer accepted as a rare disorder and that effective treatment exists. For patients who do not respond to oral chlorimipramine, the treatment of choice, intravenous chlorimipramine is suggested as a viable alternative.

Administration, Oral↗
PubMed1986

A psychiatric intensive care unit in a general hospital setting.

A twelve month period of the functioning of a psychiatric intensive care unit in a general hospital is reviewed. The unit has actually been functioning for about three and a half years. Although there were growing pains initially, the unit has become an integral part of the psychiatric inpatient service. It serves to provide intensive care to acutely ill patients and provides a safe, secure environment. It also reduces the number of disturbed patients on the two general units. Very disturbed patients are expertly managed by the staff and a surprisingly low percentage of patients have to be transferred to the local mental hospital under certification. The experience demonstrates that a psychiatric intensive care unit based on a general medical intensive care unit model can function well with benefit both to patients and staff.

Alberta↗
PubMed1975

A case of manic-depressive illness in childhood.

A case of manic-depressive illness in a boy of 14 is presented and discussed. The illness began at the age of 12, before the onset of puberty, and conformed with most of the criteria set out by Anthony and Scott for the diagnosis of manic depressive illness in childhood. Some of the literature on bi-polar affective illness in childhood is reviewed and the case is discussed.

Adolescent↗
PubMedDate not supplied

Obsessive-compulsive disorder in schizophrenia.

OBJECTIVE: To examine the differences in demographic and clinical features of patients with schizophrenia, with or without comorbid obsessive-compulsive disorder (OCD). METHODS: Fifty-two subjects were recruited from clinical services in the city of Edmonton, Alberta and assessed for schizophrenia and OCD with structured clinical interviews and standardized clinical rating scales. RESULTS: The prevalence of OCD in individuals meeting criteria for schizophrenia was 25%. Those subjects having both schizophrenia and OCD scored significantly higher on the Y-BOCS, Hollingshead scale, and GAF; plus significantly lower PANSS negative symptoms and a trend in increased Parkinsonian symptoms compared with individuals with schizophrenia alone. CONCLUSION: Our preliminary findings indicate that patients with schizophrenia and OCD vary in selected demographic and clinical measures when compared to patients with schizophrenia alone. Patients with schizophrenia and OCD appear to have less negative symptoms, which may thus be reflected in the decreased GAF scores. It is speculated that patients with schizophrenia and OCD may have a greater propensity to basal ganglia dysfunction than those with schizophrenia alone resulting in increased Parkinsonian symptoms.

Adult↗