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Biomedical subjects

L Watt

Publications and source records attributed to L Watt.

11 recordsLinked to original sources

Protein meal-stimulated pancreatic polypeptide secretion in Prader-Willi syndrome of adults.

Children with Prader-Willi syndrome (PWS) are characterized by obesity, hyperphagia, hypogonadism, and mental retardation with underlying hypothalamic dysfunction and are known to have blunted or absent pancreatic polypeptide (PP) secretion in response to protein meals. In this communication, adults (26 +/- 3 years of age) with PWS were compared with age-matched normal obese and normal weight controls in regards to plasma glucose, insulin, PP, cholecystokinin (CCK), cholesterol, and triglyceride after a high protein meal. Compared with normal weight controls, adults with PWS showed a smaller and delayed rise in plasma insulin, and relatively smaller and delayed PP elevation whereas obese controls revealed hyperglycemia, markedly higher insulin, and moderately higher PP, cholesterol, and triglyceride levels than those with PWS. There was a small increment of CCK levels after a protein meal in all groups of adults. After a protein meal, the molar ratio of PP to CCK doubled in normal weight and PWS groups, and this ratio tripled in the normal obese group, suggesting no reduced PP secretion in PWS in response to CCK stimulation. PP hyposecretion in PWS thus appears to be a part of multiple endocrinopathy associated with hypothalamic dysfunction.

Adult

Repeat self-harm: an 18-month follow-up.

An 18-month follow-up of cases of deliberate self-harm (DSH) revealed that 30% had repeated the act. Of a large number of items recorded at index DSH only one, a past history of self-harm, was associated with repetition. It is suggested that some factors not predictive of longer term repeat DSH may be important in the assessment of risk for immediate further self-harm.

Female

Wegener's granulomatosis and autoantibodies to neutrophil antigens.

We report five cases of Wegener's granulomatosis all of whom had clinical and histological evidence of disease activity at presentation and in whom autoantibodies to neutrophil antigens were detected. This test may prove useful for the diagnosis of this serious condition and help to monitor disease activity during treatment.

Adult

Deliberate self harm--correlates of suicidal intent and severity of depression.

In a study of 98 cases of deliberate self harm, a high correlation was obtained between a diagnosis of Major Depressive Disorder (M.D.D.) and scores on both the Hamilton Rating Scale for depression (HRS) and the Suicide Intent Scale (SIS). There was also a high correlation between HRS and SIS scores. A higher score on HRS and SIS correlated with increasing age, as also did a diagnosis of M.D.D.

Adolescent

Chlamydial infection of the urogenital tract in promiscuous and non-promiscuous women.

Chlamydia trachomatis infection of the urogenital tract of women presumed to be non-promiscuous, and in presumably promiscuous women attending a Special Clinic in Manchester was studied. Two hundred female members of hospital staff, who formed the non-promiscuous group, were found to have a 1% incidence of chlamydial infection. This compared with an incidence of 26% among 200 women attending the clinic. Among the clinic patients, chlamydial infection was significantly linked with the presence of gonorrhoea, mixed infections, and other sexually transmissible diseases--such as, trichomoniasis. No correlation could be made be made between the incidence of chlamydial infection and the use of oral contraceptives.

Chlamydia Infections

Trichomoniasis.

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Adolescent