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Biomedical subjects

L Weise

Publications and source records attributed to L Weise.

7 recordsLinked to original sources
PubMed2000

[Surgical treatment of hepatic alveolar echinococcosis].

INTRODUCTION: Alveolar hydatid disease is an uncommon parasitosis found in the northern hemisphere, caused by the larval stage of a tapeworm growing in the liver: Echinococcus multilocularis. It behaves like a malignant tumor, producing liver necrosis and invading the biliary tract, main vessels and surrounding structures. METHODS: Review of the different therapeutic approaches in hepatic alveolar echinococcosis over 21 years in an epidemic area. RESULTS: The various surgical approaches (all types of hepatectomy, palliative surgical procedures and liver transplantation) were combined with medical, endoscopic and radiological interventional treatment. Recently, asymptomatic forms were more frequently encountered. CONCLUSIONS: The wide use of ultrasonography and specific serological tests have led to early diagnosis, allowing more curative hepatectomies.

Echinococcosis, Hepatic↗
PubMed1999

Genetic determinants of drug-induced agranulocytosis: potential risk of olanzapine?

Whether or not olanzapine causes bone marrow toxicity is still a matter of debate. In spite of pre-marketing and post-marketing clinical trials, and although there have been no cases in animals of olanzapine-induced neutropenia or agranulocytosis, the risk of bone marrow toxicity cannot be excluded. The present paper addresses the following questions: what is the potential background of drug-induced agranulocytosis? Are there any case reports supporting the view that olanzapine has relevant bone marrow toxicity? What strategies might be helpful in identifying the pathological mechanisms underlying this side effect?

Adult↗
PubMed1982

[Whipple's disease].

With regard to three cases, one of them relapsing after four years, a short survey on Whipples's disease is given. The 3 male patients of medium age suffered from malabsorption and foregoing arthralgia. These symptoms are typical. In most cases first of all chronic infectious or neoplastic diseases are taken into consideration. The finding of PAS-positive macrophages in biopsies of the duodenal mucosa is key to the diagnosis, allowing the successful antibiotic therapy, with preference to oxytetracyline.

Anti-Bacterial Agents↗
PubMed1979

[Perspective of tuberculosis control--role of preventive chemotherapy (author's transl)].

After a short review of measures for control and eradication of infectious diseases in general and especially of tuberculosis, the indications of chemoprophylaxis and preventive chemotherapy of tuberculosis are discussed. Using results of a double-blind controlled trial on preventive chemotherapy in a high risk group (persons with fibrotic lung lesions), cost, benefit and side effects of preventive chemotherapy are analysed. Preventive chemotherapy in high risk persons is an effective measure in advanced stage of tuberculosis control. Recommendations to reduce side effects are given.

Diabetes Complications↗
PubMed1976

[The frequency and form of manifestation of liver damage under INH therapy].

It is reported on 305 clinically examined patients with the diagnosis of a functional colon syndrome. In 65 patients somatic diseases were found to be the possible triggering factors. In contrast to a comparative group in the other 240 patients in the former anamnesis more frequently allergies, appendectomies and chronic application of purgatives were to be established. The most frequent complaints were irregularity of defaecation in form of spastic obstipation (62.9%) or diarrhoea (35.4%), intolerance to foodstuff (100%), pain in the colon(66.7%) and meteorism (65.4%). The 4th decennium was most frequently concerned in men as well as in women.

Alcoholism↗
PubMedDate not supplied

The effects of scopolamine on memory for time in rats and pigeons.

In Experiment 1, pigeons were trained to match short (2 s) and long (8 s) sample durations to red and green comparison stimuli and red and green samples to vertical and horizontal line comparisons. They received injections of scopolamine hydrobromide (0.02 mg/kg), scopolamine methylbromide (0.02 mg/kg), or saline, and the delay interval was manipulated (0, 1, 3, and 9 s). In Experiment 2, rats were trained to discriminate short (2 s) or long (12 s) durations of house-light illumination using a choice procedure. During the test phase of each trial, the left and right levers were presented with the cue light on above one of them (cued lever) while the other was off (uncued lever). For half of the rats, the correct response following the short sample was to press the cued lever, whereas following the long sample, it was to press the uncued lever. This was reversed for the remaining rats. The rats received injections of scopolamine hydrobromide (0.15 mg/kg), scopolamine methylbromide (0.15 mg/kg), or saline, and the delay interval was manipulated (0, 1, 3, and 9 s). In pigeons, scopolamine equivalently disrupted both temporal and nontemporal memory. Memory for time, in both rats and pigeons, was significantly poorer following scopolamine injections than following methylscopolamine or saline injections. No choose-short effect was observed in either rats or pigeons during saline test sessions. The data indicate that central cholinergic blockade in both pigeons and rats disrupts the accuracy of delayed temporal discriminations. However, scopolamine does not appear to accelerate the rate at which memory for temporal events is foreshortened.

Animals↗