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Biomedical subjects

L Xu

Publications and source records attributed to L Xu.

At least 541 records · Page 30Linked to original sources

[Treatment of esophageal and cardial stricture with TiNi memory alloys srent].

A thermal-shaped memory metal stent, which is made of Nitinal, used in 95 patients with malignant tumors and 35 patients with anastomosis stenosis tumor resection. All patients had no opportunities of surgical operation and no response to dilation radiotherapy, chemotherapy, lasertherapy and traditional Chinese medicine. Dysphagia ameliorated in all patients after stent therapy. The mean dysphagia grade varied from 3.71 +/- 0.45(range 3-4) to 1.08 +/- 0.59 (range 0-2)(P < 0.01). Complications occurred in 49 patients (31.5%), including chest pain in 36, local bleeding in 5, tumor overgrowth in 4, stent migration in 2, and food obstraction in 2. In summary, treatment with placement of a Nitinol stent is effective, safe and simple in our patients with dysphagia which were due to malignant esophageal and cardiac strictures and is feasible for some benign esophageal and cardiac strictures as well through our clinical practice and observation nearly three years.

Aged↗

[Expression of vasoactive intestinal peptide receptor in human colonic carcinoma cell membranes].

To evaluate the expression of vasoactive intestinal peptide receptor in colonic carcinoma cell membranes in men and to assess the relationship between the receptor characteristics and the histopathologic features, the authors labelled vasoactive intestinal peptide and measured vasoactive intestinal peptide receptor sites with radio-ligand bind assay on 12 specimens from colon cancer and its adjacent normal tissues. The number of the vasoactive intestinal peptide receptor sites of colon cancer was significantly smaller than that of the adjacent normal tissues (2.66 +/- 3.84 pmol/mg versus 10.54 +/- 17.99 pmol/mg, and the number of the receptor sites of colon cancer was not well related to the degrees of cancer differentiation. This study has laid the basis for the regulation of the receptor-ligand binding to inhibit the growth of colon cancer.

Adenocarcinoma↗

[Chemical constitutents of Podocarpus imbricatus BI. (II)].

From Podocarpus imbricatus five compounds were isolated and identified as 2"-O-rhamnosylvitexin (I), hinokiflavone (II), ecdysterone (III), beta-sitosteryl heptadecoate (IV) and daucosterol(V) on the basis of spectral studies (UV, IR, 1HNMR, 13CNMR, MS) and chemical reactions. I, II, III, IV are obtained from this plant for the first time, and IV is obtained as beta-sitosteryl odd number carboxylic ester for the first time.

Biflavonoids↗

[Microscopic identification of the powder of roots of genus Adenophora: II. The roots of Sect. Remotiflorae and Sect. Adenophora].

This paper deals with the microscopic characteristics of the powder of the roots of 11 species and subspecies of Genus Adenophora. The results show that Sect. Basiphyllae, Sect. Pachydiscus, Sect. Remotiflorae and Sect. Adenophora can be identified based on the amount and thickness of the wall as well as the characteristics of the pit of sclerified cork cells, and 29 species, subspecies and varieties can be identified based on the amount, shape and thickness of the walls of the sclerified cork cells, the diameter and pit of the vessels, the number and shape of the secretion of the laticifers, and the number of inulin crystals.

Magnoliopsida↗

[Chemical constituents of the leaves of Ginkgo biloba].

Four compounds were isolated from ethyl acetate extract of the leaves of Ginkgo biloba. Compounds II, III, IV were identified as ginkgolides A, B and C respectively, Compound I, which was obtained from the leaves of G. biloba for the first time, was identified as 3,3'-dimethoxy-4,4'-dihydroxy-stilbene by spectroscopic methods.

Diterpenes↗

[Suicide gene therapy for glioma using HSV-tk/GCV system].

OBJECTIVE: To establish a suicide gene therapy system HSV-tk/GCV for glioma treatment in vitro as well as in vivo and test its efficacy. METHODS: C6 rat glioma cells were infected with recombinant retrovirus containing HSV-tk gene. Following selection the C6/tk cell line which stably expressed tk was cloned. The sensitivities of C6/tk cells to several nucleoside analogues, such as GCV, BVdU, ACV, were compaired by the growth inhibition studies. Antitumor effects were also observed after GCV treatment in nude mice bearing tumors derived from C6/tk cells. RESULTS: The growth inhibition studies showed that GCV was the most efficient prodrug, and C6/tk cells were highly sensitive to GCV, with an IC50 < 0.2 mumol/L, being 500-fold less than that in tk-negative C6 cells. In vivo studies showed similar results. Significant tumor inhibition was found in the treatment group. CONCLUSION: Tumor cells expressing HSV-tk gene can be eradicated by administration of GCV in vitro as well as in vivo.

Animals↗

[Direct protection of injured primary cultured hepatocytes of rats treated with carbon tetrachloride by salvianic acid B].

The incorporation of [3H]thymidine obviously tends to decrease in the primary cultured hepatocytes of rats when the cells are treated with carbon tetrachloride. Meanwhile the activity of ALT markedly increases in the medium. But these pathologic alterations are inhibited by Salvianic acid B(SA-B) and the effect of 10(-6) mol/L SA-B is the best.

Alanine Transaminase↗

[An adaptive method for image enhancement of retinal vascular images based on morphology and human visual properties].

A method of contrast enhancement for retinal vascular images is provided. Opening of a gray-scale image by a gray-scale structuring element(SE) can generate a background image. Enhancement is achieved by subtracting this background image from the original image and then applying a adaptive gray-scale modification technique which is based on the local contrast of the image and the lobserver's Just-Noticeable-Difference(JND). As the method includes certain human visual properties and treates smooth and detail areas of a retinal image differently, the common problems of producing ringing artifacts around sharp transition regions and excessive enhancement of noise for many traditional enhancement methods are avoided. Another advantage of this method is the retention of vessel dimension which directly benefit from using morphological opening filter. The suggested method performed very well both analytically and visually.

Fluorescein Angiography↗

[Chemical composition of Fagopyrum cymosum (Trev.) Meisn].

From the ethanolic extracts of the aerial parts of Fagopyrum cymosum, eleven compounds were isolated, of which eight have been identified as benzoic acid(1), beta-sitosterol(2),5,5'-di-alpha-furaldehyde dimethyl ether(3), p-hydroxybenzoic acid(4), rutin(5), quercetin(6), daucosterol(7), succinic acid(8) by spectroscopic methods. Compound 3 is obtained from the genus for the first time.

Drugs, Chinese Herbal↗

Pulmonary leiomyosarcoma.

Three cases of pulmonary leiomyosarcoma were presented. The characteristic clinical features were described with review of literature. In comparison with bronchogenic carcinoma, the leiomyosarcoma has some characteristics: 1) On chest X-ray, it usually appears as a sharply demarcated, even density round mass, growing rapidly within the lung, it unusually accompanies with hilar or mediastinal lymph node metastasis; 2) The preoperative cytological or pathological diagnosis is difficult either by sputum smear or by bronchoscopic biopsy or by fine needle percutaneous aspiration biopsy; 3) Pathological differential diagnosis of leiomyosarcoma of lung from anaplastic lung cancer is difficult. In conclusion, the primary pulmonary leiomyosarcoma is a rare malignant tumor, detecting the present illness seriously, paying attention to the chest X-ray films characterize, early surgical resection is the only way to get diagnosis and effective treatment method.

Adult↗

Diagnosis and treatment of stage-III peripheral squamous cell carcinoma of right upper lung.

During a 12-year period, 44 patients were surgically treated for stage-III peripheral squamous cell carcinoma of the right upper lobe. The mean time from the discovery of the shadow in the right upper lobe to the confirmation of the diagnosis was 2 months. All patients underwent the resection of the right upper lobe with the dissection of the right mediastinal lymph nodes, among them, 4 patients had sleeve lobectomy of the right upper lobe. P-TNM staging: 23 cases were in stage-IIIa, 21 cases in stage-IIIb. The frequency of the postoperative complications was 20.4% (9/44 cases). The 1-year survival rate of all patients was 61% (27/44 cases). None of stage-IIIb patients lived longer than 3 years. The postoperative 3- and 5-year survival rates of stage-IIIa cases were 65.2% (15/23 cases) and 21.7% (5/23 cases) respectively. In this article, the patients' clinical features, the causes of delayed-diagnosis, the operative and postoperative management were discussed. We suggest that the stage-IIIa patients should be given surgical treatment, whereas, for the patients of stage-IIIb, palliative operation was given just for the purpose of reliving the symptoms.

Aged↗

Thymic carcinoma (report of 14 cases).

This paper reports of 14 cases of thymic carcinoma. Most of them with symptoms of chest pain, chest stuffy and discomfort, but without combined with extrathoracic syndromes. The tumors always were large in size and frequently invaded adjacent organs, hence with low resection rate. In this series, complete resection of tumor only 2 cases, partial resection in 7 cases, exploratory thoracotomy in 5 cases. Thymic carcinoma was an extremely malignant tumor with extensive invasion intrathoracally and early metastasis extrathoracally. The common sites of metastasis were bone, liver, lung and extrathoracic lymph nodes. Adjuvant therapy postoperatively was given to all patients. Follow-up of 1-8 years showed 10 cases death, of which 5 cases died within the first year after surgery, 3 cases within the second year. Four patients were still alive so far, in which 3 patients were within 1.5 years postoperatively. Pathological studies revealed 9 cases of squamous epithelial cell thymic carcinoma, 3 of lymphoepithelioma-like thymic carcinoma and 2 of small cell undifferentiate thymic carcinoma.

Adult↗

[Survey on medicinal resources of Syngnathidae].

A survey on medicinal resources shows 12 species belonging to 7 genera of Syngnathidae are used as traditional Chinese medicine and some problems about cultivated Haima have been discussed.

Animals↗