Biomedical subjects

L Y Lai

Publications and source records attributed to L Y Lai.

At least 19 recordsLinked to original sources

PubMed1989

Predisposing locus for Alzheimer's disease on chromosome 21.

Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimer's disease of genetic aetiology have a predisposing locus on chromosome 21.

Adult↗

PubMed1982

Genetic variation in Bougainville and Solomon Islands populations.

This paper reports the findings of genetic variation in eight populations of the Solomon Islands. Blood specimens collected from 345 Aita, 191 Nasioi and 416 Nagovisi of Bougainville, 379 Lau, 453 Baegu and 385 Kwaio of Malaita, and 504 Ontong Java, and 328 Ulawa subjects were tested for A-B-O, M-N-S-s, Rh, Hp, Tf, secretor, and red-cell acid phosphatase systems. Considerable differences were found among the eight populations with respect to all polymorphic systems studied. It was not possible to distinguish Austronesian groups from non-Austronesian groups on the basis of gene frequencies.

ABO Blood-Group System↗

PubMed1981

Vitamin C and the common cold: using identical twins as controls.

We analysed self-reported cold data for 95 pairs of identical twins who took part in a double-blind trial of vitamin C tablets. One member of each twin pair took vitamin C and the other took a well matched placebo each day for 100 days. Vitamin C had no significant effect except for shortening the average duration of cold episodes by 19%.

Adolescent↗

PubMed1981

Vitamin C and the common cold: a second MZ Cotwin control study.

Self-reported cold data have been analyzed for 95 pairs of identical twins aged 14-64 who took part in a double-blind trial of vitamin C tablets. One member of each twin pair took a tablet containing 1 g vitamin C and the other took a well-matched placebo each day for 100 days. In the total sample there was no effect of vitamin C in preventing colds. However, subdivision of the data showed a significant preventive effect of the placebo in the 51 pairs living together and an equal and opposite preventive effect of the vitamin C in the 44 pairs living apart. The placebo effect in the pairs living together may be attributed to the large proportion who wrongly perceived which treatment they were taking. The reduction of colds in the vitamin C group of the pairs living apart was about 20%. There were significant correlations between cold symptoms reported and the personality trait of neuroticism. No side effects of substantive changes in serum biochemistry could be attributed to the vitamin C dose.

Adolescent↗

PubMed1978

The workshop concept in training of health personnel.

A description is given of the planning, conduct and evaluation of four workshops for health personnel. Components common to all programmes are used to derive a basic model which could be used for educational training training. The results indicate that participants found their workshop experience valuable and relevant to education in the health sciences.

Australia↗

PubMed1977

Health status of a group of narcotic addicts in a methadone treatment programme.

This study, which arose out of a concern for the health status of narcotic addicts already in a treatment programme, has demonstrated that there is a severe level of impairment of general health. A summary of important findings is reported. Narcotic addiction leads to secondary medical morbidity and mortality, but health impairment also follows the gross disorder of living which has its roots in childhood, and early adolescent experience. Successful prevention and rehabilitation needs to be based on this knowledge.

Adult↗

PubMed1974