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Biomedical subjects

L Yannuzzi

Publications and source records attributed to L Yannuzzi.

10 recordsLinked to original sources
PubMed1993

Improvement in visual function after displacement of the retinal elevations emanating from optic pits.

OBJECTIVE: To define the functional deficit that correlates with the inner layer separation and the outer layer detachment that have been observed in optic pit maculopathy and to determine the effect of a gas tamponade that compresses or displaces the two layers. DESIGN: The central visual field before and after a gas tamponade on the posterior pole were charted on a 1-m tangent screen and compared with the changes in the retina observed biomicroscopically and with stereophotography. SETTING: The gas operations were done at four hospitals in the New York, NY, area and one in Cleveland, Ohio. The retinal examinations, visual field testing, and stereoscopic photography for eight patients were done at The New York Hospital. The patient who lived in Cleveland was examined and photographed in Cleveland. PARTICIPANTS: Nine patients between the ages of 18 and 46 years with optic pit maculopathy. INTERVENTION: The patients were operated on by five retinal surgeons with a variety of procedures. Four patients had a vitrectomy and intraocular gas injected. Five patients had gas injected after external compression. Two patients had laser applied in conjunction with the intraocular injection. The gas tamponade was the unifying factor. RESULTS: The dense central scotoma in optic pit maculopathy relates to the outer layer detachment and displacement of it from the posterior pole yields an improvement in visual acuity. The inner layer separation persists centrally after a gas tamponade and continues to provide access for the flow of fluid from the pit. The scotoma that relates to the inner layer separation is mild and consistent with relatively good visual acuity.

Adolescent↗
PubMed1991

The effects of lipid lowering on diabetic retinopathy.

The effect of lipid lowering on hard exudates was determined in six consecutive patients with insulin-dependent diabetes mellitus. Diet and hypolipidemic drug therapy including the use of pravastatin, a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A reductase, were used to treat patients for one year. The total cholesterol concentration decreased from a mean baseline value of 231 mg/dl to a treatment mean value of 165 mg/dl. The mean low-density lipoprotein cholesterol concentration decreased from 157 mg/dl to 93 mg/dl. Masked grading of fundus photographs indicated an improvement in hard exudates in all six patients and a decrease in microaneurysms in four patients. Visual acuity improved in one patient and did not change (one line or less change) in five patients. No remarkable side effects resulting from treatment were observed. Our pilot study suggests that aggressive therapy of diabetic patients with hyperlipidemia may have a beneficial effect on background retinopathy.

Adult↗
PubMed1988

Retinoschisis associated with optic nerve pits.

Stereoscopic transparencies studied with magnification and projection suggest that the retinal elevation that communicates with optic pits is frequently a schisislike separation of the internal layers of retina. Thirteen of 15 eyes with optic pits and maculopathy fit the schisis pattern. Separation of the outer layers of the retina is a secondary phenomenon that starts in the macula.

Adult↗
PubMed1987

Diagnosis of pseudoxanthoma elasticum by scar biopsy in patients without characteristic skin lesions.

Pseudoxanthoma elasticum is a disorder of connective tissue that is associated with numerous systemic complications, including accelerated atherosclerosis, gastrointestinal bleeding, angioid streaks in the ocular fundus, and blindness. Diagnosis of the disease is important because many of its complications can be prevented and genetic counseling can be offered to family members of affected patients. The purpose of this study was to examine the usefulness of scar biopsy in establishing a diagnosis of pseudoxanthoma elasticum in patients with angioid streaks but without characteristic skin lesions. Ten patients with angioid streaks but without cutaneous findings indicative of pseudoxanthoma elasticum were evaluated by biopsy of scars and flexural skin. The biopsy specimens were compared with those from unaffected controls. In 6 of the 10 patients, scar biopsies showed fragmentation and clumping of elastic tissue in the deep dermis. Three patients also had these histologic features of pseudoxanthoma elasticum in biopsy specimens of flexural skin that appeared to be normal. We conclude that biopsies of scars in randomly chosen sites may be useful when pseudoxanthoma elasticum is suspected despite the absence of typical skin lesions.

Adult↗
PubMed1987

Skin necrosis following fluorescein extravasation. A survey of the Macula Society.

Three patients developed cellulitis and skin necrosis following fluorescein dye extravasation. This experience prompted a survey of the Macula Society membership to determine whether this complication of fluorescein angiography is as rare as the paucity of cases in the literature suggests. In addition, the manufacturer was asked to reexamine the dye lot to determine whether an impurity had been introduced unintentionally during the manufacturing process. No impurity was found in the dye lots tested. The survey disclosed only nine additional cases of skin necrosis, leading to the conclusion that skin necrosis probably represents a rare, idiosyncratic reaction. Although fluorescein angiography remains a safe procedure, efforts should be directed toward prevention of dye extravasation. When extravasation does occur, prompt and proper medical attention with close follow-up study may minimize the likelihood of skin necrosis.

Aged↗
PubMed1986

Electrophysiological assessment of aphakic cystoid macular oedema.

Focal electroretinograms (FERG), pattern electroretinograms (PERG), and visual evoked potentials (VEP) were studied in a group of 30 aphakic patients with cystoid macular oedema (ACME). When compared with a control group of age-matched aphakics, 35% of patients were found to have abnormal FERG responses and 53%--over half of whom had normal FERG responses--showed abnormal PERG amplitudes. Although most of the patients had associated optic disc leakage, VEP latencies were normal in 26 out of 30. These results may explain the more severe visual loss seen in some ACME patients where the ophthalmologically visible retinal changes do not seem sufficient to explain such reduction in vision.

Adult↗
PubMed1978

Choroidal neovascularization associated with choroidal nevi.

We observed choroidal neovascularization with associated macular detachment in three cases of benign choroidal nevi. Successful obliteration of the neovascular membranes was performed with argon laser photocoagulation with maintenance of good central visual acuity.

Adult↗
PubMed1976

Cystoid macular edema in the first week after cataract extraction.

Fluorescein angiography was safely performed in 100 consecutive cases of cataract extraction during the first postoperative week. Seventy-five percent of the 100 eyes had good quality fluorescein angiograms. Four eyes demonstrated cystoid macular edema. Therefore, the incidence of cystoid macular edema in the first week after cataract surgery was low when compared to the reported incidence (40%) four to six weeks postoperatively.

Adult↗
PubMed1976

Retinal detachment secondary to branch vein occlusion: Part I.

Eight patients with retinal detachment secondary to branch vein occlusion were studied. Retinal detachment secondary to branch vein occlusion occurs when the vein occlusion is severe and there is marked capillary nonperfusion and leakage. The detachment is limited to the area of the occluded vein and does not extend beyond the equator. Usually the detachment is shallow; however, it can be bullous as demonstrated in 3 of our patients. Fluorescein angiography revealed the typical findings associated with branch vein occlusion, in addition to late pooling of the dye into the fluid in the subretinal space. In each of the 6 cases treated by laser photocoagulation, reattachment of the retina occurred. The disease is discussed from the standpoint of ocular findings, fluorescein angiography, diagnosis and differential diagnosis, course, treatment, and prognosis.

Age Factors↗