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L Zöbeli

Publications and source records attributed to L Zöbeli.

8 recordsLinked to original sources
PubMed1990

Thyroiditis after treatment with interleukin-2 and interferon alpha-2a.

Serial thyroid functions studies were carried out in patients with melanoma and renal cell carcinoma treated with interleukin-2 (3 MU m-2 by continuous infusion days 1-4) and interferon alpha-2a (6 MU m-2 subcutaneously on days 1 and 4), both given on alternate weeks. The results on eight patients who completed at least three cycles of treatment are described. Four patients developed thyroid dysfunction with a hyperthyroid phase of 2 weeks followed by a hypothyroid phase ranging from 12 to 24 weeks. Two patients became clinically symptomatic and required treatment. Fine-needle aspirates of the thyroid were obtained in three patients with thyroid dysfunction. The cytology revealed a mixed cellular infiltrate with lymphocytes and histiocytes, and immunocytochemical staining showed strong HLA-DR expression of all thyrocytes, both suggestive of an autoimmune thyroiditis. One patient with thyroiditis developed anti-thyroglobulin antibodies, the serology of all other patients was normal. Patients with thyroid dysfunction tended to have higher in vivo stimulated lytic activity of peripheral mononuclear blood cells and had significantly higher levels of CD16 positive blood cells as compared to euthyroid patients. The possibility of autoimmune thyroiditis should be anticipated in future trails combining interleukin-2 and interferon alpha-2a.

Adult↗
PubMed1989

[Evaluation of fine needle puncture of the breast mass].

Fine-needle aspiration (FNA) biopsy for cytology is an established, widely accepted, safe and very accurate method permitting morphological investigation of nodules within the breast. It represents an important part of the preoperative "triple diagnostic" which includes clinical examination, mammography and FNA. In a palpable malignancy, FNA permits a definitive diagnosis of cancer in 90-95% of the cases. False-positive results should be extremely rare (about 0.2%), whereas false-negative results cannot always be prevented (5-10%). This high accuracy of cytologic method, however, can be realized only under ideal conditions. If any possible, FNA should be performed by the cytologist himself in the cytology laboratorium; the possibility of direct clinical and anamnestic information, the optimal handling of the aspirated material, by necessity the immediate control of cells amount and preservation by quick stain, the immediate repetition of an insufficient aspiration within the same session: this are very important factors for diagnostic efficiency of cytologic method. If aspiration has to be performed outside the cytology laboratory, a close contact between the cytologist and the physician who performs aspiration is indispensable. If both (these possibilities) cannot be realized, the open surgical biopsy is considered as the best alternative to FNA.

Biopsy, Needle↗
PubMed1988

[Cytological diagnosis of hepatocellular carcinoma based on ultrasonically guided fine needle biopsy].

1902 ultrasonically guided fine needle aspirations of liver were examined in the Cytology Department of the Institute of Pathology, University Hospital of Zürich, in the period 1977 to March 1987. 75 of the patients had hepatocellular carcinoma which was confirmed by clinical follow-up, laboratory data and/or by histology. In 71 cases (94.6%) malignancy was diagnosed with certainty or was strongly suspected. There were no false positive diagnoses of malignancy. 2 cases of well differentiated hepatocellular carcinoma were interpreted as liver cell hyperplasia. Hepatocellular carcinoma was distinguished from metastatic tumors in 68 of 75 cases (= 83%). In 7 cases a metastatic process was misinterpreted as primary liver cell carcinoma. However, in 3 cases tumors diagnosed as metastases proved to be hepatocellular carcinomas. The efficacy and limits of the technique of ultrasonically guided fine needle aspiration in the diagnoses of liver pathology are discussed.

Aged↗
PubMedDate not supplied

Fine needle aspiration of the liver. Significance of hepatocytic naked nuclei in the diagnosis of hepatocellular carcinoma.

Fine needle aspiration (FNA) smears from 60 cases of histologically (34) or clinically (26) confirmed hepatocellular carcinomas were reviewed. In about 90% of the cases, the cytologic preparations contained clusters of malignant cells with variable degrees of hepatocytic features and a distinctive type of naked nuclei. These naked nuclei had features similar to those of the malignant hepatocytes, but with more evident atypia. They were numerous in about 75% of the cases and less frequent in 15%; in three cases, they were practically absent. All three cases of well-differentiated hepatocellular carcinomas presented with numerous naked nuclei with slight atypia. Flowerlike-configured naked nuclei were especially found in poorly differentiated hepatocellular tumors. Hepatocytic naked nuclei were rarely found in FNA smears from normal liver, metastases, cysts or degenerative, regenerative and inflammatory liver processes; when seen in these cases, they showed no atypia. The presence of atypical hepatocytic naked nuclei appears to be a very useful criterion for the diagnosis of hepatocellular carcinoma.

Adenoma, Bile Duct↗