Biomedical subjects

L Zajdel

Publications and source records attributed to L Zajdel.

5 recordsLinked to original sources

PubMed1999

Metastatic trophoblastic disease following partial hydatidiform mole: case report and literature review.

A patient with a triploid partial hydatidiform who had lung metastasis is presented. Complete response was achieved with methotrexate chemotherapy. A review of the literature revealed only 11 previously reported cases. In many of them clinical data are missing. All had lung metastasis and 1 had in addition a metastasis in the vagina. Only 1 of these patients died of disease. The others responded well to chemotherapy. Metastatic trophoblastic disease following partial mole is very rare but the exact prevalence is not known. Since risk factors for developing metastatic trophoblastic disease subsequent to partial mole are not known, all patients should be followed.

Abortion, Missed↗

PubMed1996

Evaluation of mucinous metaplasia of the prostate gland by mucin histochemistry.

OBJECTIVE: To evaluate the presence of mucinous metaplasia in normal and benign hyperplastic prostates, using stains for neutral and acidic mucins. PATIENTS, MATERIALS AND METHODS: Normal prostate glands were removed during the post-mortem examination of 11 consecutive subjects (median age 45 years, range 17-79) who had died accidentally. Specimens were also obtained from 10 patients (median age 70.2, range 61-82) undergoing suprapubic prostatectomy for prostatic hyperplasia. The specimens were examined histologically; sections were stained using the periodic acid-Schiff (PAS) method for neutral mucins and the alcian blue (AB) method at pH 2.5 for acidic mucins. The positive sections were also immunostained for high molecular weight cytokeratin (KER), and prostate-specific antigen (PSA) using the strept-avidin-biotin (SAB) method. RESULTS: Mucinous metaplasia was found in six of the normal prostates and in three of the hyperplastic glands. Usually, the cells were tall columnar, containing both AB- and PAS-positive material. The cells were negative both for PSA and KER. Mucinous metaplasia affected all ages, including a 17-year-old, and mostly involved the inferior periurethral area. CONCLUSION: Benign mucinous metaplasia was more frequent than previously appreciated, involved all ages, was mainly periurethral and did not correlate with the usual distribution of adenocarcinoma of the prostate.

Adenocarcinoma, Mucinous↗

PubMed1996

Extralobar sequestration presenting as massive hemothorax.

Pulmonary extralobar sequestration is a rare anomaly, usually diagnosed during the first months of life. A case of extralobar pulmonary sequestration in an adult, manifesting itself as massive hemothorax, is presented.

Bronchopulmonary Sequestration↗

PubMed1994

[Cat scratch disease].

Cat scratch disease (CSD) is usually manifested in children and young adults as a benign, chronic self-limited lymphadenopathy. However, various atypical presentations have been described, especially in immunocompromised hosts. 1 of 5 cases of CSD diagnosed here during 1985-1993 is presented. In 3 cases the diagnosis was supported by lymph node biopsy in which the organisms were visualized by Warthin-Starry silver impregnation staining. Recent publications indicate that Afipia felis and Rochalimaea henselae, both Gram-negative bacilli, were isolated from infected lymph nodes in CSD. The usual benign course does not necessitate antibiotic therapy. The antimicrobial agents effective in cases with systemic symptoms were rifampicin, ciprofloxacin, trimethoprim-sulfamethoxazole and gentamicin. In view of the increasing number of cats, an increased incidence of CSD may be expected. The mechanism of transmission from cat to man is still unknown. Fleas or ticks may be involved. Hopefully, recent advances in the identification of the causative organisms may lead to the development of serological tests, reducing the need for skin testing and lymph node biopsy.

Adult↗

PubMed1992

Carotid body tumor: diagnostic and therapeutic approach.

Carotid body tumor may be clinically suspected when the only clues are physiologic manifestations of carotid body dysfunction or when a palpable cervical mass is evident upon presentation. In the latter case, the physiologic signs of carotid body dysfunction are usually recognizable. We have presented the case of a patient who was completely disabled by a slowly enlarging carotid body tumor. An attempt at surgical excision of the tumor was unsuccessful because of its proximity and adhesion to vital neck structures. An endocardial pacemaker inserted to ameliorate the episodes of bradycardia and hypotension accompanied by transient complete atrioventricular block resulted in only partial and temporary relief. Finally, irradiation of the tumor induced fast shrinkage and rapid regression of symptoms.

Carotid Body Tumor↗