Structure-activity relationships of 2-(1H-imidazol-1-yl)vinyl ethers. Route to the new broad-spectrum antifungal agent omoconazole.
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Animals↗
Biomedical subjects
L Zirngibl
Publications and source records attributed to L Zirngibl.
[New biologically active theophylline derivatives. Synthesis and pharmacologic properties of flufylline and fluprofylline].
Within the course of the research project for finding new cardiovascular drugs we have synthetized since 1976 piperazine- and piperidine derivatives of theophylline. The screening shows for the substances Sgd 19578 (flufylline) and Sgd 14480 (fluprofylline) a long-lasting blood pressure lowering activity as well as a remarkable serotonin- and histamine antagonism and broncholytic activity. On the basis of these results these compounds were selected for further investigation.
5-Hydroxytryptophan↗
Fifteen years of structural modifications in the field of antifungal monocyclic 1-substituted 1H-azoles.
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Animals↗
1-amino-3-phenylindoles with antidepressant activity. Binodaline hydrochloride and related substances.
From a number of novel N-alkylated derivatives of 1-amino-3-phenyl-indole tested as tetrabenzaine antagonists, binodaline hydrochloride (X) has been selected as a potential antidepressant substance for clinical trials. The structure of the side chain is compared to that of known tricyclic antidepressants.
Animals↗
[Transformation of 16-alpha-epoxy- 16-beta-methylpregnenolone with ammonia and primary amines].
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Amines↗
[On a steroid with a probable oxazoline structure].
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Chemical Phenomena↗