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Biomedical subjects

L von Gerstenbergk

Publications and source records attributed to L von Gerstenbergk.

9 recordsLinked to original sources
PubMed1981

[Selective induction of tumors in Wistar rats with loop colostomy after administration of methyl-(acetoxymethyl)-nitrosamine (MAOMN) (author's transl)].

A single dose of 7 mg/kg methyl-(acetoxymethyl)-nitrosamine in Wistar rats with double loop colostomy induced adenomas, papillomas, and adenocarcinomas at the site of colostomy in 83% of the treated animals. The mean induction time was 320 days. The pronounced local effect as well as the high tumor yield are discussed in regard to the evident high epithelial sensitivity at the colostomy site.

Adenocarcinoma↗
PubMed1981

Experimental studies on microcirculation under normobaric hyperoxia using the microspheres method.

The perfusion of the heart, kidneys, adrenals, stomach, intestines, brain and musculature under normobaric hyperoxia was studied in anaesthetized mini pigs using radioactively labelled microspheres. After a 2-hour control period using room air, the influence of normobaric hyperoxia on the perfusion of the organs was measured at 2-hour intervals. A significant increase in the perfusion of tissue was found in the kidneys, adrenals, gastro-intestinal tract and brain after 4-6 hours of exposure. No change in perfusion could be demonstrated for the myocardium. Values for the skeletal musculature (diaphragm and musculus psoas) were widely scattered, but an increase could be suspected. The increase in tissue perfusion at constant blood pressure and pulse rate must be interpreted as an expression of vasodilation. These results are contrary to the majority of statements in the literature, which mainly report vasoconstriction under normobaric hyperoxia.

Adrenal Glands↗
PubMed1979

[Studies of gastric circulation in the dog. III. Remaining blood flow in the dissected stomach (author's transl)].

After mobilisation of the stomach for high anastomosis between esophagus and stomach, gastric blood flow is maintained by only one gastric artery. Total and regional gastric blood flows are measured in 13 dogs using the microspheres method after ligation of three main gastric arteries. In any part of the stomach blood flow does not decline below 40% of the initial blood flow. Blood flow to mucosa of corpus and fundus is hardly reduced even after this drastic reduction of total gastric blood flow. Blood flow in the muscle layer of the fundus is reduced to about 38% if supplied only by the right gastroepiploic artery. Different operative procedures of replacements of the esophagus are discussed.

Animals↗
PubMed1979

[Gastric blood flow in animals. I. Normal blood flow (author's transl)].

Total and regional gastric blood flow were measured in 15 dogs under control conditions (mean AOBP 100 mm Hg) using microspheres labelled with different isotopes (125J, 141Ce, 85Str, 46Sc) of 8 mu size. The mucosa in fundus and corpus showed significantly higher blood flow compared to the antrum. There was no difference in the muscular layer for either part of the stomach. It is concluded from these data that differences in regional blood flow in the unstimulated stomach of the dog are related to different energy-demands within the stomach.

Animals↗
PubMed1978

[Blood flow in the swine stomach in hemorrhagic shock].

In nine conscious piglets, total and regional gastric blood flow was measured (8 microns radioactive microspheres) in the same animals before (control) and at the end of a 3-h hemorrhagic shock period (mean AoBP = 40 mm Hg). Gastric blood flow decreased dramatically (88.4%) during shock. This decrease was most severe in the mucosa of corpus and fundus, where the highest flow was registered during control and where stress lesions are usually found. The reduction in gastric flow was significantly greater than the reduction in cardiac output (45.1%). The disproportional reduction in gastric blood flow may be explained by the high alpha-adrenergic activity of splanchnic organs (2) and by the impediment to liver outflow (1) during hemorrhagic shock.

Animals↗
PubMed1976

[Lose-dose treatment with vitamin A in prevention of stress ulcer in swine].

Hemorrhagic shock in 8 piglets (mean AoBP 40 mm Hg for 3 h) was followed by severe stress-induced gastric mucosal lesions (Gr-I). When vitamin A was administered simultaneously (50,000 IE/kg = Gr. II, n = 6 and 5,000 IE/kg = Gr. III, n = 7) during the procedure, no stress lesions were observed. The study shows that the simultaneous application of vitamin A during hemorrhagic shock, in a reasonable clinical dosage, protects the gastric mucosa against stress-induced lesions.

Animals↗