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Lajos Jakab

Publications and source records attributed to Lajos Jakab.

9 recordsLinked to original sources
PubMed2005

[Klippel-Trenaunay syndrome].

The author in connection with three properly observed female patients summarizes the clinical entity of Klippel-Trenaunay syndrome, its partly resembling partly dissociating features facing to other vascular congenital anomalies, and the most important aspects of vasculogenesis. Based on the observation, attention is distinctly called on the first case in whom the Klippel-Trenaunay syndrome presenting with multiple mesenchymal anomalies was associated with selective congenital IgA deficiency. The second was the daughter of this first patient, who also had the syndrome and a selective congenital IgA deficiency. The other daughter of the patient was free from both of the pathological conditions. The third case represented the features of the typical syndrome without verified immunodeficiency. The literary data do not speak about possible correlations between Klippel-Trenaunay syndrome and immunodeficiencies. The pathogenesis of the process and of its possible connections with immunodeficiencies remain to be investigated.

Adult↗
PubMed2004

[Glycosaminoglycans, proteoglycans, atherosclerosis].

Glycosaminoglycans, proteoglycans have fundamental roles in the building up of the vascular walls. The research work of the correlations between glycosaminoglycans, proteoglycans and the pathogenesis of atherosclerosis was since more decades proceeding. The prominent experts of the scope are paying more and more attention to the significant influence of the inflammation ongoing in the arterial vessel wall. Glycosaminoglycans, proteoglycans are equally contributing to the development, stopping or remaining, turning into chronic type of the inflammatory process. On the ground of all these this article makes an attempt to outline, using up the newest results of the investigations being in relation with the fundamental structures, the alterations in the composition, the occurrences, the essential functions of the glycosaminoglycans, proteoglycans. Afterwards the diverse important roles of these molecular organizations played in the pathogenesis, in the progression of atherosclerosis, and in the arising of its complications are surveyed. Basing on the considerable data of the observations it can be established that glycosaminoglycans, proteoglycans have determining importance in the individual, peculiar inflammation progressing in the arterial vessel wall, in the surviving of the special vasculitis, in the appearance of atherosclerosis, in the focal nature and progression of that and in the development of its complications. The knowledge becoming continuously more complete affords, a long-range expectation in relation to both the prevention and therapeutic intervention of that widespread disease.

Arteriosclerosis↗
PubMed2003

[The pathogenesis of atherosclerosis].

The article dealing with the pathogenesis of atherosclerosis, summarizes the knowledge, which relies on the latest investigative results, and which is in connection with the starting of atherosclerosis and with the chronic type inflammation ongoing in the arterial vessel wall, having individual characteristics. Then the general features of the inflammatory response of the organism, the emerging infections, just as that of the autoimmune phenomena are touched upon. The importance of the contribution to the pathogenetic chain of the lipoproteins, the connective tissue matrix proteoglycans and glycosaminoglycans is summed up in distinct chapters. The distinguished significance of the attachment between the proteoglycans and lipoproteins, oxydized lipopoteins is particularly underlined. It is established that the chronic nature inflammatory process, possessing individual characteristics, has essential role in the starting, development and in the entire course of the pathological process. The impacts of infections, and that of the possible immunodeficiencies are uncertain. In the author's opinion the definition of atherosclerosis syndrome might be as follows. The point is a non specific chronic inflammatory response of the organism in the form of a specific vasculitis, which constitutes ground to the development of the atherosclerotic process.

Arteriosclerosis↗
PubMed2002

Human fetuin/alpha2HS-glycoprotein level as a novel indicator of liver cell function and short-term mortality in patients with liver cirrhosis and liver cancer.

OBJECTIVE: Human fetuin/alpha2HS-glycoprotein (AHSG) is synthesized by hepatocytes. We intended to determine whether liver dysfunction or acute phase reaction is dominant in the regulation of its serum concentrations and to see if decreased AHGS levels are associated with short-term mortality. DESIGN: We determined the serum AHSG levels in patients with acute alcoholic, acute A, B, and Epstein-Barr virus hepatitis, alcoholic cirrhosis, and hepatocellular cancer and correlated them to conventional laboratory parameters of inflammation and liver function. Patients were followed for 1 month. METHODS: Serum AHSG was determined by radial immunodiffusion. RESULTS: Compared to controls, significantly lower AHSG levels were found in patients with liver cirrhosis and hepatocellular cancer but not the acute viral hepatitides. Strong positive correlation with serum transferrin, albumin and prothrombin was found. Febrile episodes were not associated with significantly decreased AHSG levels. Concentrations below 300 microg/ml were associated with high mortality rate (52.0%; relative risk, 5.497; 95% confidence interval, 2.472-12.23; P < 0.0001). Of all laboratory parameters studied serum AHSG levels showed the greatest difference between deceased and survived patients with cirrhosis and cancer. Moreover, other acute phase reactants did not differ significantly. The multiple logistic regression analysis indicated that the decrease of serum AHSG is independent of all other variables that were found decreased in deceased patients. CONCLUSIONS: Decreased serum AHSG concentration is due rather to hepatocellular dysfunction than the acute phase reaction and is an outstanding predictor of short-term mortality in patients with liver cirrhosis and liver cancer.

Acute-Phase Reaction↗
PubMed1997

Polychondritis Terminating in Eosinophilic Leukemia.

We report here on a patient presenting with Relapsing Polychondritis (RP) two years before the diagnosis of Myelodysplasia (MDS) terminating in Eosinophilic Leukemia (EoL). The evolution of RP several etiology of RP in this patient. The terminal development of EoL in our case is assumed to represent clonal evolution caused by a second mutagenic event. The existence of autoimmune skin disorders in both the patient and his offspring (vitiligo and subacute cutaneous lupus erythematosus, respectively) implies that the coexistence of MDS and RP may have been caused by a functional disturbance of the immune system.

Journal Article↗
PubMedDate not supplied

Pearson-type I distribution function for polydisperse polymer systems. Molar mass distribution.

This paper presents an attractive feature of the distribution function, which uses a relatively simple expression for approximating probability density. The Pearson-type I distribution function is used to represent the molar mass distribution (MMD) function for polymers for which the number average (M(n)), mass average (M(w)), z-average (M(z)), and (z+1)-average (M(z)(+1)) values are available. In continuation, the Pearson-type I distribution is applied as the model MMD function in which model parameters (M(n), M(w), M(z), and M(z)(+1)) are fitted from experimentally determined MMD. As the result, different molar mass averages are estimated with satisfactory agreement with experimental data.

Journal Article↗