Unlocking the power and potential of the Cas12 family members and their ancestors for crop genome editing.
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Biomedical subjects
Publications and source records attributed to Lanqin Xia.
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Native Fanzor2 nucleases exhibit weak editing activity in plants. An optimized Fanzor2 system engineered via ωRNA optimization and structure-based protein mutagenesis achieves robust editing at recalcitrant genomic sites and enables cytosine base editing, supporting versatile crop genome modification via transformation or viral delivery.