Biomedical subjects

Larry F Ellison

Publications and source records attributed to Larry F Ellison.

3 recordsLinked to original sources

PubMed2005

An empirical evaluation of period survival analysis using data from the Canadian Cancer Registry.

OBJECTIVE: To provide an empirical evaluation of the performance of period analysis in comparison to traditional methods of survival analysis for predicting future 5-year cancer survival using data from the Canadian Cancer Registry. METHODS: 5-year relative survival estimates were derived by period and traditional methods of analysis using data available at the conclusion of 1997. The extent to which these estimates agreed with survival later observed for cancer cases diagnosed in 1997 was quantified by calculating the squared difference of the estimate to the corresponding relative survival ratio actually observed. RESULTS: Period analysis was observed to be superior to, or comparable with, cohort analysis in predicting the average 5-year relative survival observed later for virtually all individual cancer sites studied. The improvement in survival estimation was most pronounced for prostate cancer. Where period estimates did not match the eventually observed value, they were predominantly on the lower side. Complete analysis estimates were generally observed to be in between the cohort and period values. CONCLUSIONS: The period method of survival analysis provides more up-to-date estimates of 5-year survival than do traditional cohort-based methods.

Adolescent↗

PubMed2004

Variation in breast cancer counts using SEER and IARC multiple primary coding rules.

OBJECTIVE: To determine breast cancer case counts, on a given data set, using both Surveillance, Epidemiology, and End Results (SEER) program and International Agency for Research on Cancer (IARC) multiple primary coding rules and to describe differences, if any, by age at diagnosis, histology, stage at diagnosis, laterality, and grade. METHODS: SEER and IARC multiple primary coding rules were applied to a dataset provided by the North American Association of Central Cancer Registries. Only registries whose data met high quality data standards for the time period studied (1994-1998) and whose permission was obtained were included. Percentage differences were calculated using IARC counts as the base. RESULTS: Using IARC multiple primary rules resulted in 2.4% fewer cases. Among females, the highest percent changes by category were: age group - 80-84 year-olds (3.4%); histology - inflammatory breast cancer (4.6%); stage - distant (3.1%); grade - well differentiated (3.0%). Among males, the highest percent changes by category were: age group - 80-84 year-olds (1.7%); histology - for intraductal and lobular breast carcinoma in combination (4.8%); stage - distant (3.0%); grade - well differentiated (1.8%). Overall differences were generally unaffected when examined by laterality. CONCLUSION: Breast cancer case counts are dependent on the multiple primary coding rules used.

Age Factors↗

PubMed2004

Leading cancers--changes in five-year relative survival.

OBJECTIVES: Changes in five-year relative survival ratios for prostate, breast, colorectal and lung cancer cases are examined. Ratios for cases diagnosed in the 1985-1987 period are compared with those for 1992-1994. Incidence and mortality rates between 1985 and 1999 are compared with changes in relative survival. DATA SOURCES: Data are from the Canadian Cancer Registry, the National Cancer Incidence Reporting System, the Canadian Mortality Data Base, and life tables. ANALYTICAL TECHNIQUES: Analysis was conducted using the maximum likelihood method of Esteve. Age-standardized ratios for a given cancer were calculated by weighting age-specific ratios to the age distribution of patients diagnosed with that cancer. Statistical tests were used to compare corresponding age-specific and age-standardized ratios across the two periods. National estimates exclude Québec and New Brunswick. MAIN RESULTS: Between the 1985-1987 period and the 1992-1994 period, increases in five-year age-standardized relative survival ratios were dramatic for prostate cancer, large for breast cancer, and somewhat smaller for colorectal cancer. There was little absolute change in the ratios for lung cancer.

Adolescent↗