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Biomedical subjects

Larry Janssen

Publications and source records attributed to Larry Janssen.

6 recordsLinked to original sources

Performance of a full facepiece, air-purifying respirator against lead aerosols in a workplace environment.

This study evaluated workplace performance of a full facepiece, negative pressure, air-purifying respirator with P100 filters in a lead refining plant. Air samples for lead were collected inside and outside the respirators worn by workers who were properly trained and quantitatively fit tested. Trained observers assisted in the study to ensure sample validity. Three to four pairs of air samples per day were collected from each worker for a total of 52 valid sample sets. Lead was found on all the outside samples, and concentrations were below the detection limit for all but one of the inside samples. The single measurable inside sample yielded a workplace protection factor (WPF) of 297. WPFs for the rest of the samples were estimated using the assumption that lead was present at the detection limit for the in-facepiece samples. Calculated WPFs were rounded down to the nearest 100 then subjected to a rank and percentile function. The 5th percentile WPF was approximately 900 using this approach. These WPFs exceed the assigned protection factor (APF) of 50 for this respirator class recommended by the National Institute for Occupational Safety and Health and listed by the Occupational Safety and Health Administration. These results support the APF of 50 for this respirator and indicate the respirator provided adequate protection as used in this study.

Aerosols↗

The effect of pressure drop on respirator faceseal leakage.

Users of particulate air-purifying respirators are typically told to change their filters when breathing resistance becomes uncomfortable. It has been proposed that a noticeable increase in breathing resistance (pressure drop) may increase airflow through respirator faceseal leaks. This logic has been extended to suggest that respirator user exposure to contaminants may increase because of this theoretical increase in air leakage. Procedures similar to those of previous investigators were used to study this issue. Repeated faceseal leak rate measurements were made at -5.6 through -20.1 mm water pressure drops across the faceseal. Subjects were divided into two groups, representing acceptable fit or unacceptable fit, based on leak rate criteria prescribed by the Occupational Safety and Health Administration (OSHA). Subjects with acceptable fit did not experience an increase in faceseal leak rate with increased pressure drop. Leak rates for subjects with unacceptable fit were highly variable and did not show an association with pressure drop. Results of this study do not support the concept of increased faceseal leakage with increased pressure drop. The evidence does not suggest increased risk of contaminant exposure through the face seal as pressure drop increases.

Adult↗

Principles of physiology and respirator performance.

Several respirator performance criteria are set to satisfy the physiological requirements of the worker. In particular, Ve and PFI must be understood and used appropriately in the design process. Filtration principles and the nature of workplace aerosols must also be understood to determine appropriate test conditions for particulate respirator filters. Current filter test criteria assure that significant aerosol penetration will not occur in the workplace. It is unlikely that existing positive-pressure respirators can assure positive pressure in the breathing zone at all times for all wearers. High, unsustainable work rates and activities such as running in place have been shown to cause negative-pressure excursions under laboratory and workplace conditions. Because these excursions are brief and infrequent for today's respirators, both logic and performance measurements indicate they have a negligible effect on exposure. Filters could no doubt be designed to pass extreme test criteria. Similarly, it may be possible to design positive-pressure respirators to maintain positive pressure 100 percent of the time for all users. However, it is likely that cost and size would increase and comfort could decrease. Further, available evidence demonstrates that today's respirators provide their expected level of protection when properly selected, used, and maintained. As such, there is no demonstrated need for radical design changes.

Aerosols↗

Evaluation of a quantitative fit testing method for N95 filtering facepiece respirators.

A method for performing quantitative fit tests (QNFT) with N95 filtering facepiece respirators was developed by earlier investigators. The method employs a simple clamping device to allow the penetration of submicron aerosols through N95 filter media to be measured. The measured value is subtracted from total penetration, with the assumption that the remaining penetration represents faceseal leakage. The developers have used the clamp to assess respirator performance. This study evaluated the clamp's ability to measure filter penetration and determine fit factors. In Phase 1, subjects were quantitatively fit-tested with elastomeric half-facepiece respirators using both generated and ambient aerosols. QNFT were done with each aerosol with both P100 and N95 filters without disturbing the facepiece. In Phase 2 of the study elastomeric half facepieces were sealed to subjects' faces to eliminate faceseal leakage. Ambient aerosol QNFT were performed with P100 and N95 filters without disturbing the facepiece. In both phases the clamp was used to measure N95 filter penetration, which was then subtracted from total penetration for the N95 QNFT. It was hypothesized that N95 fit factors corrected for filter penetration would equal the P100 fit factors. Mean corrected N95 fit factors were significantly different from the P100 fit factors in each phase of the study. In addition, there was essentially no correlation between corrected N95 fit factors and P100 fit factors. It was concluded that the clamp method should not be used to fit-test N95 filtering facepieces or otherwise assess respirator performance.

Adult↗