Biomedical subjects

Lars Rindorf

Publications and source records attributed to Lars Rindorf.

2 recordsLinked to original sources

PubMed2006

Calculation of optical-waveguide grating characteristics using Green's functions and Dyson's equation.

We present a method for calculating the transmission spectra, dispersion, and time delay characteristics of optical-waveguide gratings based on Green's functions and Dyson's equation. Starting from the wave equation for transverse electric modes we show that the method can solve exactly both the problems of coupling of counterpropagating waves (Bragg gratings) and co-propagating waves (long-period gratings). In both cases the method applies for gratings with arbitrary dielectric modulation, including all kinds of chirp and apodization and possibly also imperfections in the dielectric modulation profile of the grating. Numerically, the method scales as O(N) where N is the number of points used to discretize the grating along the propagation axis. We consider optical fiber gratings although the method applies to all one-dimensional (1D) optical waveguide gratings including high-index contrast gratings and 1D photonic crystals.

Journal Article↗

PubMed2006

Towards biochips using microstructured optical fiber sensors.

In this paper we present the first incorporation of a microstructured optical fiber (MOF) into biochip applications. A 16-mm-long piece of MOF is incorporated into an optic-fluidic coupler chip, which is fabricated in PMMA polymer using a CO(2) laser. The developed chip configuration allows the continuous control of liquid flow through the MOF and simultaneous optical characterization. While integrated in the chip, the MOF is functionalized towards the capture of a specific single-stranded DNA string by immobilizing a sensing layer on the microstructured internal surfaces of the fiber. The sensing layer contains the DNA string complementary to the target DNA sequence and thus operates through the highly selective DNA hybridization process. Optical detection of the captured DNA was carried out using the evanescent-wave-sensing principle. Owing to the small size of the chip, the presented technique allows for analysis of sample volumes down to 300 nL and the fabrication of miniaturized portable devices.

Biosensing Techniques↗