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Biomedical subjects

Laurent Coudeville

Publications and source records attributed to Laurent Coudeville.

6 recordsLinked to original sources
PubMed2006

Strategies for containing a global influenza pandemic.

Mathematical modelling provides useful insight into the geographic and temporal spread of pandemic influenza. It has been recently used to assess the ability to stop a pandemic at a very early stage. Here, we model the global diffusion of pandemic influenza and the impact of available preventive and control measures. We refined a published SEIR deterministic model of disease dynamics within 52 cities interconnected via air transport to simulate the impact of five interventions in a variety of scenarios: vaccination, case isolation, therapeutic and prophylactic antiviral treatment, and air traffic reduction. The impact of these measures was assessed on the spread of a potential pandemic strain profile, with an average attack-rate of 26%, a case-fatality rate of 2.5% and a residual immunity of 25%. Our analysis highlighted the importance of: (1) a global perspective for dealing with pandemic risks; (2) the time factor and, hence, the importance of surveillance systems; (3) the complementary role of available control measures. Results provide general guidance for the issues of concern to public-health decision-makers: when to set up interventions, where, and at which administrative levels.

Antiviral Agents↗
PubMed2004

Varicella vaccination in Italy : an economic evaluation of different scenarios.

AIM: To determine the economic impact (cost-benefit analysis) of childhood varicella vaccination, with the Oka/Merck varicella zoster virus vaccine live (Varivax) in Italy. METHODS: This analysis is based on an epidemiological model of varicella zoster virus (VZV) dynamics adapted to the Italian situation. Cost data (Euro, 2002 values) were collected through a literature review. Several vaccination scenarios were analysed: (i) routine vaccination programme for children aged 1-2 years with different levels of vaccination coverage (90%, 70% and 45%) without any catch-up programme; (ii) routine vaccination programme for children aged 1-2 years with different levels of vaccination coverage (90%, 70% and 45%) completed by a catch-up programme for 6-year-old children over the first 5 years of vaccine marketing; and (iii) routine vaccination programme for children aged 1-2 years with different levels of vaccination coverage (90%, 70% and 45%) completed by a catch-up programme during the first year of vaccine marketing for children aged 2-11 years. PERSPECTIVES: A societal perspective, including both direct and indirect costs, and a health-system perspective, limited to costs supported by Italian Health Authorities, were considered. RESULTS: A routine vaccination programme has a clearly positive impact on chickenpox morbidity. Respectively, 68% and 57% of chickenpox-related hospitalisations and deaths could be prevented with a 90% coverage rate. With vaccination costs being more than offset by a reduction in chickenpox treatment costs in the base case, such a programme could also induce savings from both a societal and a health-system perspective (40% and 12% savings, respectively for a 90% coverage rate). A lower coverage rate reduces cost savings, but there is still a 9% decrease in overall societal costs for a 45% coverage rate. Although the reduction in total societal costs was robust to the sensitivity analyses performed, a slight uncertainty remains regarding cost reduction from a health-system perspective. However, in this latter perspective, even in the worst-case scenario of the sensitivity analysis, routine vaccination programmes may be cost effective, the worst-case scenario for cost parameters leading to cost per life-year gained of Euro2853. Catch-up programmes combined with routine vaccination should lead to further cost reductions from a societal perspective: 15% for a massive catch-up during the first year of vaccine marketing compared with toddlers' vaccination alone, and 11% for a catch-up focused on 6-year-old children for a period of 5 years. However, the impact of catch-up programmes on the costs from an Italian health-system perspective remains close to zero (+/-1%). CONCLUSION: This model suggests, with its underlying assumptions and data, that routine ZVZ vaccination may be cost saving from both a societal and a health system perspective in the base case. In the worst-case scenario of the sensitivity analysis, vaccination remains cost effective.

Adolescent↗
PubMed2004

National survey of endodontics in general dental practice in France.

The purpose of this paper was to gather both qualitative and quantitative information on endodontic treatments performed by French dental practitioners, and to identify the factors influencing the duration of endodontic procedures. A questionnaire was addressed in a two-rounds distribution to 2000 dentists selected by the quotas method in the whole country. A total of 790 (39.5%) questionnaires containing useful information were returned. The duration of endodontic treatment increases according to the number of roots to treat. The pulpal preoperative status has an influence on the duration of treatment, which is longer for a tooth with a necrotic pulp. Three variables strongly influence the duration of endodontic treatment: the number of patients attended per day, the number of appointments required for this treatment and the presence of a wage earner in the office. Continuing education also seems to be a variable having some influence on the duration of treatment. Financial considerations are also taken into account and there was general agreement that the current remuneration system of the French Health National Insurance is inadequate. Further, when one compares the total cost of an endodontic treatment with the fees fixed by the Health Insurance, it is clear that such procedures afford no positive financial return for a majority of practitioners. Moreover, the return becomes even more negative for teeth with a necrotic pulp. The findings presented in this study constitute the first stage of the medico-economic analysis concerning the endodontic practices in France. Prospective studies to gather precise information on the duration of endodontic treatments and a cost-analysis of endodontic practices could assist in the decision making process for practitioners or for the policy makers in the formulation of policies regarding application and reimbursement of endodontic treatment.

Appointments and Schedules↗
PubMed2003

Measles dynamics and vaccination diffusion. A model and an application.

Although numerous mathematical models focusing on measles dynamics have been proposed in the literature, efforts in this area have concentrated essentially on the mechanisms of measles propagation. If present, vaccination diffusion is treated as an exogenous factor. Here we propose a model focused on the course of measles in France in which the mechanisms of vaccination diffusion are explicitly modeled. The parameters in this model are estimated by an original method based on an expectation-maximization algorithm. This model gives indications of the way in which measles propagation and vaccination diffusion interact. It also allows discussion of the possibility of eliminating this disease in France in the near future.

Journal Article↗
PubMedDate not supplied

The economic value of childhood varicella vaccination in France and Germany.

OBJECTIVE: To determine the economic impact of childhood varicella vaccination in France and Germany. METHODS: A common methodology based on the use of a varicella transmission model was used for the two countries. Cost data (2002 per thousand) were derived from two previous studies. The analysis focused on a routine vaccination program for which three different coverage rates (CRs) were considered (90%, 70%, and 45%). Catch-up strategies were also analyzed. A societal perspective including both direct and indirect costs and a third-party payer perspective were considered (Social Security in France and Sickness Funds in Germany). RESULTS: A routine vaccination program has a clear positive impact on varicella-related morbidity in both countries. With a 90% CR, the number of varicella-related deaths was reduced by 87% in Germany and by 84% in France. In addition, with a CR of 90%, routine varicella vaccination induces savings in both countries from both societal (Germany 61%, France 60%) and third-party payer perspectives (Germany 51%, France 6.7%). For lower CRs, routine vaccination remains cost saving from a third-party payer perspective in Germany but not in France, where it is nevertheless cost-effective (cost per life-year gained of 6521 per thousand in the base case with a 45% CR). CONCLUSION: Considering the impact of vaccination on varicella morbidity and costs, a routine varicella vaccination program appears to be cost saving in Germany and France from both a societal and a third-party payer perspective. For France, routine varicella vaccination remains cost-effective in worst cases when a third-party payer perspective is adopted. Catch-up programs provide additional savings.

Age Distribution↗