Biomedical subjects

Laurent Labbé

Publications and source records attributed to Laurent Labbé.

2 recordsLinked to original sources

PubMed1996

Relationship Between Intravascular Hemolysis and Bright Sparkling Echoes Detected by TEE in the Vicinity of Mechanical Mitral Prosthesis.

The significance of abnormal bright and sparkling echoes in patients with mechanical mitral prosthetic valves (MMPV) has yet to be established. In the present study, the incidence of this phenomenon and its relationship with hemolysis was evaluated. Thirty-five consecutive patients with MMPV, each examined by transesophageal echocardiography (TEE), were divided into four groups: (1) no bright echoes (n = 11 patients); (2) minor echoes (+) (n = 11 patients); (3) moderate echoes (++) (n = 7 patients); and (4) numerous echoes (+++) (n = 6 patients). Hemolysis was evaluated from assays of serum haptoglobin, serum lactic dehydrogenase (LDH) and hydrobutyric dehydrogenase (HDH), plasma hemoglobin, indirect bilirubin, and LDH1 and LDH2 isoenzymes. Serum haptoglobin was significantly lower in the patients with bright echoes (0.17 vs 0.63; P < 0.05). In patients with (++) and (+++) bright echoes, the plasma hemoglobin levels and indirect bilirubin levels were significantly higher than the levels found in those patients with minor echoes or with no echoes. These results suggest that bright echoes in patients with MMPV are related to intravascular hemolysis, and the more intense the echo the more severe the hemolysis. Furthermore, there was a higher incidence of bright echoes in the patients with bileaflet prosthetic valves than in those fitted with the Björk valve (84.6% vs 22%). (ECHOCARDIOGRAPHY, Volume 13, July 1996)

Journal Article↗

PubMedDate not supplied

Enhanced individual selection for selecting fast growing fish: the "PROSPER" method, with application on brown trout (Salmo trutta fario).

Growth rate is the main breeding goal of fish breeders, but individual selection has often shown poor responses in fish species. The PROSPER method was developed to overcome possible factors that may contribute to this low success, using (1) a variable base population and high number of breeders (Ne >100), (2) selection within groups with low non-genetic effects and (3) repeated growth challenges. Using calculations, we show that individual selection within groups, with appropriate management of maternal effects, can be superior to mass selection as soon as the maternal effect ratio exceeds 0.15, when heritability is 0.25. Practically, brown trout were selected on length at the age of one year with the PROSPER method. The genetic gain was evaluated against an unselected control line. After four generations, the mean response per generation in length at one year was 6.2% of the control mean, while the mean correlated response in weight was 21.5% of the control mean per generation. At the 4th generation, selected fish also appeared to be leaner than control fish when compared at the same size, and the response on weight was maximal (approximately 130% of the control mean) between 386 and 470 days post fertilisation. This high response is promising, however, the key points of the method have to be investigated in more detail.

Animals↗