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Biomedical subjects

Lawrence H Brent

Publications and source records attributed to Lawrence H Brent.

6 recordsLinked to original sources
PubMed2005

A case of persistent parvovirus B19 infection with bilateral cartilaginous and ligamentous damage to the wrists.

We describe a case of persistent parvovirus B19 infection in a 48-year-old female physician that was complicated by prolonged fatigue and arthritis associated with cartilaginous and ligamentous damage in both wrists. Nineteen months after presentation, intravenous immunoglobulin therapy resulted in clearance of parvovirus B19 viremia and a significant improvement in the symptoms of fatigue and arthritis.

Arthritis, Infectious↗
PubMed2004

Spondyloarthropathies.

The spondyloarthropathies include ankylosing spondylitis, reactive arthritis (including Reiter's syndrome), psoriatic arthritis, inflammatory bowel disease-associated spondyloarthropathy, and undifferentiated spondyloarthropathy. These diseases are linked by their association with the HLA-B27 gene and by the presence of enthesitis as the basic pathologic lesion. Additional clinical features include inflammatory back pain, dactylitis, and extra-articular manifestations such as uveitis and skin rash. The history and physical examination are the major diagnostic tools, although radiographic evidence of sacroiliitis is helpful. Therapeutic options include nonsteroidal anti-inflammatory drugs, sulfasalazine, methotrexate, and tumor necrosis factor-alpha inhibitors. Early recognition and appropriate treatment can help to limit disability.

Arthritis, Psoriatic↗
PubMed2004

Spondyloarthropathies: using presentation to make the diagnosis.

Diagnosing the spondyloarthropathies--chronic inflammatory diseases of the spine and peripheral joints that share several distinctive features--is challenging and depends on careful evaluation of the history, physical examination, and radiographs. The recent use of tumor necrosis factor inhibitors is exciting and may represent true disease-modifying drugs for these conditions.

Antirheumatic Agents↗