Biomedical subjects
Publications and source records attributed to Lawrence Trieu.
Intraductal papillary mucinous tumour of the pancreas is an uncommon distinctive pancreatic tumour characterized by dilatation of the main pancreatic duct or branch ducts as a result of excessive production and disturbance in the draining of mucin. The imaging characteristics of a case in an 82-year-old woman are compared.
BACKGROUND: Ionizing radiation from intraoperative fluoroscopy presents a serious occupational health and safety concern to orthopaedic surgeons.The long-term effects of ionizing radiation are well known; they include damage to the eyes, increased risk of haematological malignancy and carcinomas throughout the body. We studied the effect of using an attachable laser aiming guide on radiation exposure during intraoperative fluoroscopy. METHODS: A prospective, randomized controlled trial was performed at a single institution. Eight hundred and eighty consecutive orthopaedic procedures involving fluoroscopy were randomized into two groups. One group had fluoroscopy without an aiming guide, the other group had fluoroscopy with the aiming guide. Total exposure time, number of exposures and the body region examined were recorded. RESULTS: For most regions studied, no significant difference in exposure time or number of exposures was found. For hip fractures, use of the laser aiming device was associated with an increase in the number of exposures (P = 0.035), but there was no significant difference in average exposure time (P = 0.31). Use of the aiming device was associated with an increased number of exposures (P = 0.0025) and an increased exposure time (P = 0.0016)for examination of the wrist, but this may represent selection bias. CONCLUSION: Use of a laser aiming device during intraoperative fluoroscopy was not associated with decreased exposure to radiation.
BACKGROUND: In acute severe asthma, treatment must be initiated early to reverse the pathophysiology that may render airways less responsive to bronchodilation. The addition of nebulized ipratropium bromide to initial emergency department therapy improves pulmonary function, but it is unclear whether this approach results in earlier hospital discharge. The early use of bolus intravenous salbutamol has also been shown to improve outcome, including earlier discharge. We therefore assessed the relative benefits of intravenous salbutamol and nebulized ipratropium bromide in the early management of acute severe asthma in children by a double-blind, randomized, controlled trial. METHODS: This study was undertaken at a tertiary children's hospital, The Children's Hospital at Westmead, The Royal Alexandra Hospital for Children, Westmead, Sydney, Australia. Only children with severe acute asthma as determined by the National Asthma Campaign guidelines criteria and pulmonary index were included. All children received initial nebulized salbutamol therapy (2.5-5 mg salbutamol in 4 mL of normal saline depending on age) at initial emergency department presentation. If asthma remained severe 20 mins later, an intravenous cannula was inserted and intravenous methylprednisolone (1 mg/kg) was administered to all children receiving nebulized salbutamol every 20 mins. Children were then randomized to one of three groups: intravenous salbutamol (15 microg/kg as a single bolus over 10 mins), ipratropium bromide (250 microg), or intravenous salbutamol plus ipratropium bromide. All observers were blinded to treatment groups. Children were randomly assigned to receive a single-dose intravenous bolus of either saline or salbutamol and either nebulized saline or ipratropium bromide determined by a number generated randomly in the hospital pharmacy. The primary outcomes were recovery time and discharge time of each group. Respiratory and hemodynamic monitoring were continuous during the first 2 hrs of the study and then children were monitored clinically for 24 hrs. RESULTS: A total of 55 children with acute severe asthma were entered into the study over an 18-month period. The three groups were similar demographically, with a mean age of 5.9 yrs, and mean duration of attack of 19.6 hrs. No side effects or treatment intolerance were reported. Children in the groups that received intravenous salbutamol had a significant reduction in recovery time to achieving second hourly inhaled salbutamol (p =.008) compared with those administered inhaled bronchodilator alone. The addition of ipratropium bromide to intravenous salbutamol provided no significant further benefit in terms of nebulizer therapy (intravenous salbutamol compared with intravenous salbutamol plus ipratropium bromide). Children administered intravenous salbutamol ceased supplemental oxygen therapy earlier than those administered ipratropium alone at 12 hrs post-randomization (p =.0003). Children administered intravenous salbutamol could be discharged from the hospital 28 hrs earlier than those administered ipratropium bromide (p =.013). CONCLUSION: Children administered intravenous salbutamol for severe acute asthma showed a more rapid recovery time, which resulted in earlier discharge from the hospital than those administered inhaled ipratropium bromide. There was no additional benefit obtained by combining ipratropium bromide and intravenous salbutamol administration.