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Len S Goodman

Publications and source records attributed to Len S Goodman.

3 recordsLinked to original sources
PubMed2006

Carotid sinus pressure changes during push-pull maneuvers.

INTRODUCTION: The push-pull maneuver (PPM) is defined as a reduction in G-tolerance when positive acceleration (+Gz) immediately follows negative acceleration (-Gz) exposure, with the carotid baroreceptors presumably playing a dominant role in the ensuing BP (SBP) responses. The objective of this study was to determine whether application of neck pressure (NP) during the preceding -Gz phase maintains +Gz tolerance during subsequent +Gz. METHODS: There were 10 experienced men who were exposed to 3 centrifuge run types using a multi-axis centrifuge: a relaxed control run from +1.4 baseline to visual tolerance; a relaxed control PPM run (PPM-C) consisting of 5 s of -1 Gz followed by 15 s of +Gz to visual tolerance; and an experimental PPM run performed with pressurized neck (PPM-NP) consisting of -1 Gz for 5 s followed by 15 s of +Gz at the previous PPM-C G-tolerance level. RESULTS: Relaxed control G tolerance (3.6 _ 0.26 Gz) was greater vs. the PPM-C (3.0 +/- 0.21 Gz) and PPM-NP (3.1 +/- 0.20 Gz) conditions, but the two PPM conditions did not differ significantly. During -Gz, mean R-R interval for PPM-NP was significantly shorter than in the PPM-C from second 1 to second 3. During the +Gz phase, however, R-R interval responses between PPM-C and PPM-NP differed only at seconds 8 and 9. There were no differences in carotid sinus SBP between PPM-C and PPM-NP during -Gr. During +Gz, carotid sinus SBP was significantly depressed in PPM-NP and PPM-C conditions vs. Control. DISCUSSION: Application of NP during the -Gz phase, despite altering R-R interval, did not ameliorate SBP responses or reductions in G tolerance during subsequent +Gz exposure. Despite neck compression counteracting increased carotid hydrostatic pressure during -Gz, the carotid baroreceptor response is likely opposed by the aortic or other baroreceptors.

Adolescent↗
PubMed2002

Impairment of cardiovascular and vasomotor responses during tilt table simulation of "push-pull' maneuvers.

BACKGROUND: Numerous studies have shown that tolerance to positive acceleration (+Gz) is impaired subsequent to an exposure of less than +1 Gz. HYPOTHESIS: Vasodilation induced by antecedent negative Gz (-Gz) exposure delays sympathetic vasoconstriction during subsequent +Gz, further reducing G-tolerance. METHODS: There were 20 subjects tested on an electronic tilt table, and exposed to the following randomized head-up tilt (HUT) and head-down tilt (HDT) conditions: +75 degrees HUT for 60 s, followed by transition to either 0 degrees (supine) HDT, or -25 degrees HDT, or -45 degrees HDT for 7 or 15 s at tilt rate of 45 degrees x s(-1). This was followed by HUT, divided into three periods: HUT1 (approximately 3-10 s), HUT2 (approximately 15-22 s), and HUT3 (approximately 27-35 s). Systolic blood pressure (SBP) was normalized to heart and head-levels. Stroke volume (SV) was estimated using impedance cardiography; forearm blood flow (FBF) estimated by venous occlusion plethysmography and forearm vascular resistance (FVR) was calculated from FBF and SBP. Total peripheral resistance (TPR) was estimated by MAP/(SV*HR). RESULTS: Heart-level SBP decreased significantly during HDT for both HDT durations (p < 0.01). SBP increased significantly at head-level during HDT (p < 0.001). During HUT1 heart and head-level SBP decreased for all conditions (p < 0.001), recovering to baseline levels by HUT2. TPR decreased significantly for all HDT conditions (p < 0.001), with this decrease related to the degree of HDT angle (p < 0.05). During HUT1, TPR remained depressed below baseline. At HUT2, TPR remained decreased for the -45 degrees/7-s condition only (p < 0.01). FBF decreased significantly during HDT (p < 0.02), with the magnitude related to the HDT angle. FBF remained elevated during HUT1 (p < 0.01). FVR decreased as a function of HDT angle during HDT (p < 0.001), with the decrease persisting into the HUT1 phase (p < 0.01). By the HUT2 and HUT3 periods, FVR were above baseline levels for the -45 degrees HDT condition (p < 0.01). CONCLUSION: These results confirm in humans the delayed recovery of peripheral vascular resistance observed in animal studies when -Gz precedes +Gz. Since SV recovered to baseline levels during the "pull" phase (HUT1-3), with TPR and forearm vascular resistance remaining depressed, baroreflex-mediated peripheral vascular control is delayed. This delay at higher subsequent +Gz levels is dangerous for the military pilot, since symptoms of G-intolerance due to delay in head-level BP recovery will ensue at lower absolute +Gz levels during push-pull type maneuvers.

Acceleration↗