Topographically guided LASIK.
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Astigmatism↗
Biomedical subjects
Leopoldo Spadea
Publications and source records attributed to Leopoldo Spadea.
The CORTES study: corneal transplant indications and graft survival in an Italian cohort of patients.
PURPOSE: To describe the corneal transplantation activity in Italy, to assess the long-term graft survival, and to begin to outline the potential risk factors for graft outcome. METHODS: We followed a consecutive series of penetrating (PK) and lamellar (LK) keratoplasties performed with corneas procured and distributed by the Veneto Eye Bank Foundation, which provides about one third of the corneas grafted in Italy each year. RESULTS: Data on 4415 PKs and 489 LKs performed in 174 clinical centers are reported. Keratoconus was the major transplant indication (47% and 66%, respectively, for the 2 groups), followed by regraft (14%) and bullous keratopathy (14%) in the PK group and keratitis (8%) and refractive reasons (4%) for the LKs. In the 2 groups, graft survival, after 1 year, was estimated to be 95% and 93%, respectively, showing a decrease of the survival rate during the second and third years of study. Graft survival in patients with keratoconus indication was 98% in the PK group and 95% in the LK group for the whole period of observation, whereas the patients with other indications reported a survival rate ranging from 92% after 1 year to 52% after 3 years (PK) and from 89% to 85% (LK). CONCLUSIONS: CORTES is the most extensive survey on corneal transplantation in Italy that involves a large cohort of patients and a significant number of surgeons with corneal tissues processed and distributed by a single eye bank. In the first 3 years, a picture of the epidemiology of the corneal transplant has been defined. The graft survival rates were comparable to those reported by other studies for the same follow-up period. However, the follow-up of a sample of this cohort for a further 3 years will allow us to precisely estimate the long-term graft survival and to better evaluate the risk factors related to graft failure.
Adolescent↗
Photorefractive keratectomy and LASIK for the correction of hyperopia: 2-year follow-up.
PURPOSE: To evaluate the efficacy and safety of photorefractive keratectomy (PRK) and LASIK in the correction of hyperopia. METHODS: A retrospective study was conducted on 100 eyes of 56 patients with a mean hyperopia of +2.85 +/- 1.1 diopters (D) undergoing PRK and 100 eyes of 50 patients with a mean hyperopia of +4.49 +/- 1.2 D undergoing LASIK. A Zeiss Meditec MEL 70 G scan laser was used. RESULTS: After 24-month follow-up in the PRK group (100 eyes), the mean manifest refractive spherical equivalent (MRSE) was +0.34 +/- 0.92 D (36% +/- 0.5 D). Mean uncorrected visual acuity (UCVA) was 0.87 +/- 0.1; 8 (8%) eyes gained 1 line, 80 (80%) eyes had no loss or gain of lines, 10 (10%) eyes lost 1 line, and 2 (2%) eyes lost 2 lines. In the LASIK group (100 eyes), at 24-month follow-up, the mean MRSE was +0.29 +/- 0.66 D (70% +/- 0.5 D). Mean UCVA was 0.89 +/- 0.1; 6 (6%) eyes gained 2 lines, 10 (10%) eyes gained 1 line, 78 (78%) eyes had no loss or gain of lines, and 6 (6%) eyes lost 1 line. CONCLUSIONS: Photorefractive keratectomy and LASIK were both effective and safe in the correction of hyperopia. However, PRK manifested an initial temporary myopic overshoot followed by a hyperopic regression over 24-month follow-up (P < .01) whereas LASIK was associated with a faster refractive stability.
Adult↗
Photorefractive keratectomy and laser in situ keratomileusis in refractive accommodative esotropia.
PURPOSE: To evaluate the efficacy of excimer laser refractive surgery as an alternative for optical correction in patients affected by fully refractive accommodative strabismus. SETTING: Eye Clinic, University of L'Aquila, L'Aquila, Italy. METHODS: After a simulation of the cycloplegic correction with contact lenses over a 30-day period, 18 patients (6 men, 12 women, mean age 32.4 years +/- 9.4 [SD]) affected by fully refractive accommodative esotropia had refractive surgery using an excimer laser; 8 patients had photorefractive keratectomy (PRK), and 10 patients had laser in situ keratomileusis (LASIK). RESULTS: The correction of the refractive error with excimer laser allowed a reduction of the angle of deviation in all but 1 patient, who presented with a regression of refractive error and of the angle of deviation 2 years posttreatment. The 2-year follow-up showed that the mean angle of deviation in PRK was 2(Delta) esophoria at near and 0.4(Delta) esophoria at distance (P<.06); in LASIK, it was 1.7(Delta) esophoria at near and 0.2(Delta) esophoria at distance (P<.06). The difference between the 2 groups was not statistically significant at near (P = .56), at distance (P = .74), or for spherical equivalent (P = .16). CONCLUSION: Excimer laser refractive surgery seems to be useful in the correction of fully refractive accommodative esotropia.
Accommodation, Ocular↗
Enhancement outcomes after photorefractive keratectomy and laser in situ keratomileusis using topographically guided excimer laser photoablation.
PURPOSE: To evaluate the efficacy and safety of topographically guided excimer laser photoablation to retreat unsuccessful myopic and hyperopic photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK). SETTING: Eye Clinic, San Salvatore Hospital, University of L'Aquila, L'Aquila, Italy. METHODS: At least 3 months after primary PRK (Group A) or primary LASIK (Group B), 48 eyes of 42 patients were submitted to PRK or LASIK enhancements. The eyes were treated with an excimer laser linked to a computerized videokeratography unit with a topographically supported customized ablation workstation. RESULTS: The mean follow-up was 27.8 months +/- 8.2 (SD). In Group A, the uncorrected visual acuity (UCVA) changed from 0.5 +/- 0.7 logarithm of the minimum angle of resolution (logMAR) (range 20/600 to 20/200) to 0.1 +/- 0.7 logMAR (range 20/60 to 20/20); the mean best spectacle-corrected visual acuity (BSCVA) changed from 0.1 +/- 0.7 logMAR (range 20/50 to 20/20) to 0 +/- 0.7 logMAR (range 20/50 to 20/20) after the enhancement. In Group B, the UCVA changed from 0.7 +/- 0.8 logMAR (range 20/600 to 20/40) to 0.1 +/- 0.7 logMAR (range 20/40 to 20/20); the mean BSCVA improved from 0.2 +/- 0.8 logMAR (range 20/30 to 20/20) to 0 +/- 1.3 logMAR (range 20/25 to 20/20) after surgery. CONCLUSIONS: The enhancements using topographically guided excimer laser photoablation with a topographically supported customized ablation method resulted in satisfactory and stable visual outcome with good safety and efficacy after unsuccessful PRK and LASIK.
Adult↗
Pre-excimer laser and post-excimer laser refractive surgery measurements of scotopic pupil diameter using 2 pupillometers.
PURPOSE: To compare a digital infrared pupillometer with a handheld light amplification pupillometer for measuring scotopic pupil size and to evaluate if the postoperative refractive changes of the cornea can influence pupil measurements. DESIGN: Prospective noncomparative interventional case series. PARTICIPANTS: One hundred eyes, 50 myopic (mean spherical equivalent [SE] refraction [+/- standard deviation], -4.32+/-2.44 diopters [D]) and 50 hyperopic (mean SE refraction, +2.95+/-0.99 D), of 50 otherwise healthy subjects underwent photorefractive keratectomy or LASIK. INTERVENTION: The preoperative and postoperative scotopic pupil sizes were measured by 2 examiners (E1, E2) with both a handheld light amplification pupillometer (Colvard, Oasis Medical, Glendora, CA) and a digital infrared pupillometer (Eye World Pupillometer [EWP], Oculus Keratograph, Oculus Opikgerate GmbH, Wetzlar, Germany). The agreement and interrater repeatability were determined using the comparison method described by Bland and Altman. The paired Student's t test was used to evaluate the difference between the preoperative and postoperative measurements. MAIN OUTCOME MEASURES: Scotopic pupil diameter, topographic corneal refractive power, uncorrected visual acuity (VA), best spectacle-corrected VA, and manifest spectacle refraction. RESULTS: The preoperative mean scotopic pupil diameter was 6.12+/-0.90 mm with the EWP and 6.18+/-0.91 mm with the Colvard. After the surgery, mean SE refractions were -0.22+/-0.98 D (myopic patients) and +0.19+/-0.40 D (hyperopic patients). Postoperative mean scotopic pupil diameters were 6.12+/-0.89 mm (EWP) and 6.17+/-0.90 mm (Colvard). There was no statistically significant difference between preoperative and postoperative mean scotopic pupil sizes in either patient group. The limits of agreement between the 2 devices ranged from 2.24 mm (E1) to 2.12 mm (E2) preoperatively and from 2.27 mm (E1) to 2.08 mm (E2) postoperatively. The coefficient of interrater repeatability ranged from 0.56 mm (EWP) to 1.12 mm (Colvard) preoperatively and from 0.62 mm (EWP) to 1.14 mm (Colvard) postoperatively. CONCLUSIONS: The digital infrared pupillometer showed better preoperative and postoperative repeatability than the handheld light amplification pupillometer. In the present study, a mean correction of <3 D of the corneal refractive power did not seem to modify the preoperative scotopic pupil size measurements.
Adult↗
Topographically guided excimer laser photorefractive keratectomy to treat superficial corneal opacities.
OBJECTIVE: To demonstrate the efficacy and safety of topographically guided excimer laser photorefractive keratectomy (PRK) in treating superficial corneal opacities. DESIGN: Prospective, noncomparative interventional case series. METHODS: Twenty-six eyes of 24 patients with postinfectious (n = 6), post-traumatic (n = 18), and post-PRK (n = 2) scars were treated with an excimer laser linked to a computerized videokeratography unit with a topographically supported customized ablation workstation. MAIN OUTCOME MEASURES: Manifest spectacle refraction, best spectacle-corrected visual acuity (BSCVA), uncorrected visual acuity (UCVA), change of corneal clarity, and topographic indexes of surface regularity. RESULTS: The mean follow-up period was 7.7+/-2.1 months (+/- standard deviation) (range = 6-12). Corneal clarity and corneal topography patterns improved in all eyes. Uncorrected visual acuity improved from 0.7+/-0.8 logarithm of the minimum angle of resolution (logMAR) to 0.4+/-0.5 logMAR (P = 0.008), and BSCVA improved from 0.3+/-0.6 logMAR to 0.1+/-0.6 logMAR (P<0.001). The BSCVA increased in all eyes (>/=2 lines in 76.9% of eyes and 1 line in 23.1%). The mean spherical equivalent refraction changed from -0.125+/-2.77 diopters (D) to +1.33+/-1.28 D (P = 0.019). CONCLUSIONS: The use of topographically guided PRK with the topographically supported customized ablation method resulted in significant increases of UCVA and BSCVA and improved corneal clarity in all patients. The technique seems to be safe and effective for treating various superficial corneal diseases, including postinfectious, post-traumatic, and post-PRK scars.
Adult↗
Choroidal neovascularization after laser-assisted in situ keratomileusis following penetrating keratoplasty.
PURPOSE: To describe a case of choroidal neovascularization (CNV) after laser in situ keratomileusis (LASIK) following penetrating keratoplasty (PK). METHODS: Case report. RESULTS: A 30-year-old man underwent PK in both eyes for bilateral keratoconus in 1997. Two years later, best-corrected visual acuity (BCVA) was 20/40 (-6=-4.50 x 170 degrees ) in RE and 20/20 (-1.50=-0.50 x 90 degrees ) in LE. To reduce the anisometropic defect, LASIK was performed in RE. After surgery, the refractive defect in RE reduced to -1.75 x 125 degrees and BCVA improved to 20/25. Six months after LASIK the patient presented loss of vision and metamorphopsia in RE due to choroidal neovascularization. BCVA was reduced to 20/200. Photodynamic therapy was performed in RE; 1 year later BCVA was stable at 20/200. CONCLUSION: Vitreoretinal complications after LASIK occur rarely. The potential relationship between CNV and LASIK is discussed.
Adult↗
Long-term results of penetrating keratoplasty using a single or double running suture technique.
BACKGROUND: Corneal astigmatism changes after penetrating keratoplasty (PK) with single running suture (SRS) or double running suture (DRS) were evaluated in this prospective randomized study. METHODS: Sixty-eight consecutive eyes underwent PK: 35 received a SRS and 33 an anti-torque DRS using the same Hanna Suction System. All sutures were removed between 12 and 20 months after surgery. RESULTS: Within the first month after PK, a statistically significant difference was noted, with a lower mean value of astigmatism for the DRS group. The final mean postoperative videokeratographic astigmatism was 3.51+/-1.93 and 3.42+/-1.94 in the SRS and DRS group respectively (36 months' follow-up). CONCLUSIONS: Although the final astigmatism was about the same in the two suture groups, the DRS seems to lead to faster restoration of visual function due to early stability.
Adult↗
Correlation between ERG changes and FGF2 mRNA Up-regulation in patients with choroidal melanoma.
To study electroretinographic (ERG) response to light flashes in patients with choroidal melanoma and to define possible factors involved in the modification of both a- and b-wave.ISCEV standard flash-ERG was recorded from both affected and control eyes on 24 patients before surgical operation (local excision or enucleation). The choroidal melanomatous mass ranged from 33 to 2880mm(3). Tissues from both melanomatous retina-choroid complex and areas far from the melanoma (unaffected) were taken from 13 enucleated eyes to measure the level of FGF2 mRNA, utilizing the technique of semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Tissues from 10 normal eyes were used as control. The majority of patients showed a marked a- and b-wave attenuation in the affected eye with respect to the fellow eye. In 10 retinal specimens, the expression of FGF2 mRNA showed an increase in retinal regions far from the melanoma compared to control eyes. Many patients present an increase in the expression of FGF2 mRNA in the unaffected part of the retina and a clear attenuation in both a- and b-ERG components. The size of melanoma does not predict the amount of reduction in the ERG response, at least for sizes less than 1000mm(3). We suggest that the melanoma triggers a process leading to an up-regulation of FGF2 in the human eye and this up-regulation might be responsible for the ERG attenuation.
Adult↗
excimer laser phototherapeutic keratectomy for recurrent intraepithelial corneoconjunctival carcinoma.
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Adult↗
Flap measurements with the Hansatome microkeratome.
PURPOSE: To evaluate flap thickness, flap diameter, and hinge length during laser in situ keratomileusis (LASIK) and to correlate these measurements with preoperative keratometric power, central corneal thickness, and patient refraction, gender, and age. METHODS: In this prospective study of 50 eyes of 28 patients (mean age 31 +/- 6.6 yr; range, 24 to 43 yr) results of LASIK for myopia were analyzed (mean spherical equivalent refraction of -7.16 +/- 1.69 D; range, -2.75 to -13.50 D). Corneal flaps were created using the Hansatome microkeratome (Baush & Lomb Surgical) with a 160-microm plate and a 9.5-mm suction ring. Corneal thickness was evaluated using an ultrasonic 50-MHz pachymeter (Sonogage Corneo Gage Plus) and the mean keratometric power was measured with a Corneal Analysis System videokeratographic unit (EyeSys). Data were analyzed using t-test, Pearson product moment correlation coefficient, and Spearman's rho non-parametric correlation coefficients. RESULTS: Mean corneal flap thickness was 142.6 +/- 20.8 microm (range, 107 to 177 microm), mean flap diameter was 9.9 +/- 0.3 mm (range, 9.2 to 10.5 mm), and mean hinge length was 6.2 +/- 0.4 mm (range, 5.2 to 7 mm). Statistically significant correlations (P<.05) were found between mean keratometric power and flap hinge length, mean keratometric power and flap diameter, preoperative spherical equivalent refraction and flap diameter, corneal thickness and flap hinge length, as well as patient age and corneal thickness. CONCLUSIONS: The Hansatome microkeratome was an effective and safe instrument in the creation of corneal flaps for LASIK. Consideration of preoperative keratometric power and corneal thickness may help to reduce or avoid complications.
Adult↗
Latrogenic keratectasia following laser in situ keratomileusis.
PURPOSE: To evaluate keratectasia after laser in situ keratomileusis (LASIK) for high myopia. METHODS: A 49-year-old male patient with myopia of -23.50 D in both eyes underwent LASIK with a Summit Technology Apex Plus excimer laser. A Moria manually-guided MDSC microkeratome was used. Preoperative corneal topography in both eyes did not reveal underlying or fruste form of keratoconus. Four months after LASIK, a progressive keratectasia occurred in right eye and after 12 months, in left eye. Corneal transplantation was performed in both eyes. RESULTS: Histological and ultrastructural examinations were performed on one corneal button. The analysis showed regular stromal morphology and cellularity, with no sign of inflammation. The morphometric analysis showed an overall thickness of 334 microm, with a flap of 262 microm and a stromal residual bed of 72 microm, in the center of the button. CONCLUSION: A LASIK corneal flap made with a planned 120-microm plate turned out histologically to be approximately 260 microm thick, in an eye with a refractive correction of -23.50 D. The excessive flap thickness and excessive ablation produced progressive keratectasia requiring a penetrating keratoplasty.
Cornea↗