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Biomedical subjects

Levent Saydam

Publications and source records attributed to Levent Saydam.

12 recordsLinked to original sources
PubMed2006

Histopathologic examination for Helicobacter pylori as a possible etiopathogenic factor in laryngeal carcinoma.

OBJECTIVE: We investigated the presence of Helicobacter pylori in laryngeal cancer specimens to reveal whether or not this is a risk factor in the development of squamous cell carcinoma of the larynx. METHODS: Sixty-nine total laryngectomy specimens with the pathologic diagnosis of squamous cell carcinoma and 30 laryngeal tissue samples that had been taken for the investigation of nonneoplastic (polyp, nodule) diseases were studied. Specimens of both tumor and control groups were stained with hematoxylin-eosin and modified Giemsa stains, and then they were examined under a light microscope. RESULTS: In both groups, H. pylori could not be found in any of the cases. CONCLUSION: The histologic examination of our series did not reveal any clue related to the possible etiologic association between H. pylori and squamous cell carcinoma of the larynx.

Adult↗
PubMed2005

A new shoulder orthosis for paralysis of the trapezius muscle after radical neck dissection: a preliminary report.

Despite recent advances using more conservative approaches, standard classical radical neck dissection is still one of the most frequently performed procedures in head and neck cancer patients who have advanced metastatic neck disease. The trapezius muscle paralysis following division of the spinal accessory nerve results in severe pain and cosmetic disturbance related to malalignment of the shoulder joint. The objective of this study is to report our results with a newly developed orthosis to prevent and correct shoulder dysfunction following standard radical neck dissection. Thirty-four patients who underwent standard radical neck dissection as a part of their surgical treatment from 1997-2002 were rehabilitated by the shoulder orthosis. Beginning 2 weeks after surgery, the patients were allowed to use their orthosis. By using a standard questionnaire, the pain and activity scores were recorded at the 1st, 3rd, 6th and 12th months postoperatively. Six patients were excluded from the study, of whom two succumbed to their disease and four discontinued the use of the orthosis. Of 28 patients included in the study, 20 (72%) were completely pain free within 3 months following the surgery. Four patients (14%) noted their pain level as tolerable, and four patients (14%) reported no considerable gain in the pain threshold and/or physical activity levels. Despite the fact that the active abduction range increased only 5 to 20 degrees , the relief of pain and improved malalignment of the scapula and consequently clavicle and humerus led to functional gains, which increased the patients' endurance. At the end of the study, 23 patients (82%) were able to return to their previous jobs or activity levels. Current preliminary reports suggest that this orthosis can be recommended to prevent significant disability in patients with trapezius palsy due to ablative cancer surgery or other reasons.

Accessory Nerve Injuries↗
PubMed2005

Angiolipoma of the neck: a case report.

Angiolipomas of the neck are extremely rare; to our knowledge, only 2 cases have been previously reported. We report a new case, which occurred in a 28-year-old woman. The mass was totally resected, and the patient showed no recurrence at the 18-month follow-up.

Adult↗
PubMed2004

A report of four cases of acute mediastinitis occurring following tracheoesophageal puncture in laryngectomees.

Tracheoesophageal puncture is a simple procedure for speech rehabilitation of total laryngectomy patients. Despite its relative simplicity this is not an innocent technique without complications. The goal of this study was to determine the incidence of acute mediastinitis as an early postoperative complication related to this procedure and to present outcomes of non-surgical conservative management in this complication. Blom-Singer voice prosthesis was used for 51 secondary tracheoesophageal puncture procedures in 45 patients between 1994 and 2002 according to the technique described by Blom and Singer. In the postoperative period, four patients (7.8%) developed mediastinitis related to this procedure. Of these, one patient had iatrogenic perforation of the posterior esophageal wall. A false dissection plane occurred in the tracheo-esophageal party wall in three patients which subsequently resulted in mediastinitis. Mediastinitis was diagnosed by clinical and radiological findings. All of these patients required prolonged hospitalization, intravenous antibiotics, and chest tube insertion. Only one patient underwent major surgical procedure to treat this complication. In conclusion, tracheoesophageal puncture for voice restoration is now regarded as a routine procedure usually performed in outpatient conditions. However, our experience demonstrates that this technique may be associated with significant complications such as mediastinitis. If mediastinitis is recognised earlier, it may be treated with conservative measures in most of the cases.

Adult↗
PubMed2003

Laryngeal chondroma presenting as an external neck mass.

Laryngeal chondromas are rare benign tumors originating from the cartilagenous framework of the larynx. Since its first description in 1882, about 250 cases have been reported in the literature. Depending on the size of the lesion, excision via an endoscopic or open surgical approach is the treatment of choice. The majority of these patients present with an endolaryngeal mass. To encounter an external neck mass as the reason for the initial presentation is a rare occurrence. In this article we report a case of laryngeal chondroma of cricoid cartilage origin, which presented as a neck mass. The lesion was totally excised using a transcervical approach. No tracheotomy or laryngeal stent was needed postoperatively. Despite its rarity, this diagnostic possibility should always be kept in mind for elderly patients with complaints of progressive voice changes and exertional dyspnea.

Aged↗
PubMed2003

Thyroid hemiagenesis: a case report.

Thyroid hemiagenesis is usually diagnosed incidentally during examination for other thyroid gland diseases. Iodine-123 thyroid scan of a 25-year-old woman showed a normal homogeneous right thyroid lobe, but no uptake in the left lobe. Ultrasonography of the neck confirmed the absence of the left thyroid lobe, while the right lobe was homogeneous and normal. Thyroid hemiagenesis should be included in the differential diagnosis of thyroid diseases.

Adult↗
PubMed2003

[The evaluation of thyroid nodules: is routine use of frozen-section examination necessary following preoperative fine-needle aspiration biopsy? ].

OBJECTIVES: We evaluated the role of fine-needle aspiration biopsy as a single parameter in determining the extent of thyroidectomy and the necessity of routine use of frozen-section examination in patients with nodular thyroid disease. PATIENTS AND METHODS: We reviewed 67 patients (40 females, 27 males; mean age 44 years; range 17 to 78 years) who underwent thyroidectomy for nodular thyroid disease. Preoperative fine-needle aspiration biopsy and intraoperative frozen-section examination were performed in 46 patients and 40 patients, respectively. The results were compared with histopathologic diagnoses. RESULTS: Histopathologically, 25 patients (37.3%) had malignant and 42 patients (62.7%) had benign disease. The sensitivity, specificity, and diagnostic accuracy were 50%, 95%, and 77% for fine-needle aspiration biopsy, and 100%, 87%, and 91% for frozen-section examination, respectively. CONCLUSION: In view of lower sensitivity and accuracy rates for fine-needle aspiration biopsy, the routine use of frozen-section examination seems to be necessary especially in cases with highly suggestive clinical findings of malignancy.

Adolescent↗
PubMed2002

Synovial sarcoma of the pharynx: a case report.

Synovial sarcoma is a malignancy not usually encountered in the head and neck region. We describe a case of synovial sarcoma of the posterior pharyngeal wall in a 14-year-old girl. The mass was completely excised via the transoral route. Postoperatively, the patient received irradiation to 60 Gy. At 40 months of follow-up, the patient remains disease-free.

Adolescent↗
PubMedDate not supplied

Intraosseous hemangioma of the zygoma.

Zygomatic hemangioma is an extremely rare, benign, slow-growing tumor occurring mostly in adult women. The radiologic findings are diagnostic. Total excision of the tumor with primary reconstruction of the defect is the preferred treatment modality. We present a case of zygomatic hemangioma and a brief review of the literature.

Adult↗
PubMedDate not supplied

Histiocytic necrotizing lymphadenitis of the neck.

Histiocytic necrotizing lymphadenitis (HNL) also known as Kikuchi or Kikuchi-Fujimato disease is a benign and self-limiting disease. The entity was first described in 1972 by Kikuchi and Fujimato in Japan independently. HNL is prevalent in Asia, although it may be seen in a wide geographic distribution. It commonly affects young women. Cervical lymphadenopathy is the most prominent symptom and should be differentiated from lymphoproliferative, autoimmune, and postinfectious diseases. Apoptosis is the main process, taking role in pathogenesis of the disease. Although it is a well-known entity among pathologists, little is written in ear, nose, and throat literature. In this study, we report 2 male patients with HNL presenting with enlarged cervical lymph nodes with a brief review of literature.

Adult↗
PubMedDate not supplied

Early oral feeding following total laryngectomy.

INTRODUCTION: Pharyngocutaneous fistula is one of the most common nonfatal laryngectomy complications (7.6% to 65% of all total patients). Preoperative radiotherapy, advanced tumor stage, poor preoperative medical status, and concomitant pharyngectomy are usually accepted causative factors in fistula formation. Delay of oral feeding is a common practice used by head and neck surgeons to prevent the development of pharyngocutaneous fistula. In this article we analyze our experience with special emphasis given to the early start of postoperative feeding. PATIENTS AND METHODS: The postoperative records of 48 patients who had undergone total laryngectomy or total laryngopharyngectomy were reviewed. All patients were orally fed with water and clear liquids on the first postoperative day. The patients were closely observed at every feeding attempt, and if any sign of fistula was noted, a nasogastric tube was inserted. Preoperative radiotherapy, stage of disease, tumor differentiation, and pharyngectomy with total laryngectomy were statistically analyzed as potential risk factors contributing to fistula formation. The Fisher exact test was used to analyze the data. RESULTS: The overall pharyngocutaneous fistula rate was 12.5% in our series. The only statistically significant factor that increased the rate of fistula formation was resection of pharyngeal mucosa as an extension of total laryngectomy. Other parameters failed to show any statistical significance in development of this complication. CONCLUSION: Evaluation of fistula incidence in our series indicates that initiating oral feeding on the first postoperative day does not contribute to fistula formation. Additionally, the relatively shortened hospital stay and elimination of the psychologic and traumatic side effects of tube feeding are benefits of this approach that should be studied in further prospective quality-of-life studies.

Adenocarcinoma↗