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Biomedical subjects

Li Chen

Publications and source records attributed to Li Chen.

At least 253 records · Page 14Linked to original sources
PubMed2003

[An transcranial Doppler ultrasonography and X-ray study of cervical vertigo patients treated by manipulation in supine position].

OBJECTIVE: To observe the transcranial Doppler ultrasonography and X-ray changes of cervical vertigo patients caused by cervical instability before and after the manipulation treatment in supine position. METHODS: Sixteen cervical vertigo patients who underwent supine manipulation treatment were reviewed retrospectively. After the treatment, the changes of transcranial Doppler ultrasonography of cervical vertebral artery and X-ray of cervical spine were observed. RESULTS: Before the treatment, the mean blood flow velocity of vertebral artery was (48.6+/-3.1) cm/s, much higher than that of the normal group (P<0.05), the means of the horizontal displacement of C3,4 and C4,5 were (3.18+/-0.42) mm and (3.46+/-0.26) mm respectively. After the treatment, the blood flow velocity and the C3,4 horizontal displacement decreased significantly (P<0.05). The effective rate of the manipulation treatment was 100%. CONCLUSION: The manipulation treatment is an effective method for cervical vertigo patients caused by cervical instability, and the effect is correlated with the improvement of the blood flow of cervical artery and the restoration of cervical stability.

Adult↗
PubMed2003

Different approaches to caudate lobectomy with "curettage and aspiration" technique using a special instrument PMOD: a report of 76 cases.

AIM: To study different approaches to caudate lobectomy with "curettage and aspiration" technique using Peng's multifunctional operative dissector (PMOD). The surgical procedure of isolated complete caudate lobectomy was specially discussed. METHODS: In 76 cases of various types of caudate lobectomy, three approaches were used including left side approach, right side approach, and anterior approach. Among the 76 cases, isolated complete caudate lobectomy was carried out in 6 cases with transhepatic anterior approach. The surgical procedure consisted of mobilization of the total liver, ligation and separation of the short hepatic veins, splitting the liver parenchyma through the Cantlie's plane, ligation and division of the caudate portal triads from the hilum, dissection of the root of major hepatic veins, detachment of the caudate lobe from liver parenchyma. RESULTS: The mean operative time was 285+/-51 min, the mean blood loss was 1,600 ml. No severe complications were observed. Among the 6 cases receiving isolated complete caudate lobectomy with transhepatic anterior approach, one case died 17 months after operation due to disease recurrence and liver failure, the other 5 cases have been alive without recurrence, with one longest survival of 49 months. CONCLUSION: The choice of approach is essential to the success of caudate lobectomy. As PMOD and "curettage and aspiration" technique can delineate intrahepatic or extrahepatic vessels clearly, caudate lobe resection has become safer, easier and faster.

Adrenal Gland Neoplasms↗
PubMed2003

[The study of natural head posture in edentulous patients before and after oral rehabilitation].

OBJECTIVE: To study the natural head posture (NHP) of edentulous patients compared with dentate people and to understand NHP shift immediately inserting complete dentures and three months after denture wearing. METHODS: The NHPs of twenty edentulous patients and twenty-two dentate subjects were recorded with cephalometric technique. The NTPs of edentulous patients were exposed three times, before inserting, right after inserting and three months after inserting dentures. The NHPs of dentate subjects were recorded once as a controlled group. Six angles measured from the radiographs were evaluated for the NHP and three angles and two linear measures for the mandibular position. RESULTS: Compared with dentate subjects, the craniomandibular angles of the edentulous patients increased and the camber of the cervical columns decreased, but changes of the NHP were not significant. The mandible showed a significant upward moving (P < 0.05) and an insignificant forward moving. At the time of denture insertion, the camber of the cervical columns significantly increased (P < 0.05). Three months after using the dentures, the craniomandibular angles of the patients obviously decreased. (P < 0.05). CONCLUSION: The shift of NHP after denture inserting does exist. The shifted NHP of the patients with dentures is a new balanced posture and closer to the normal position than the NHP of them without dentures.

Adult↗
PubMed2003

[Dual cell seeding to improve cell retention on polytetrafluoroethylene grafts].

OBJECTIVE: To improve cell retention on the graft with dual cell seeding technique, adding a layer of smooth muscle cells (SMCs) between the graft and endothelial cells (ECs). METHODS: Polytetrafluoroethylene (PTFE) grafts pretreated with fibronectin were seeded with SMC followed by ECs one day later and exposure to an in vitro flow system. The number of ECs on grafts was counted under microscope. RESULTS: After exposure to the flow for 1 hour, 61% of the ECs lost when the ECs were seeded alone, whereas only 27% of the ECs lost when the ECs were seeded on the top of SMCs. Preconditioning of a cell seeded graft in a low rate flow did not improve cell retention when late exposure to a higher rate flow. CONCLUSION: This in vitro study indicates that using SMCs as a media layer between ECs and graft surface can improve the retention of seeded ECs on PTFE graft.

Blood Vessel Prosthesis↗
PubMed2003

[Oxaliplatin in combination with LV5FU2 for advanced/metastatic gastric cancer-a multicenter study].

OBJECTIVE: To evaluate the effects and safety of OXA-LV5FU2 regimen for patients with advanced/metastatic gastric cancer. METHODS: OXA 100 mg/m(2) i.v. 2hr d1, LV200 mg/m(2) i.v. 2hr followed by 5-Fu 400 mg/m(2) i.v. bolus and 5-Fu 600 mg/m(2) i.v. 22hr d1, 2 were given, and repeated every 2 weeks. Efficacy was evaluated at 4 cycles (8 weeks). RESULTS: Forty three patients have been entered into the study. Patients with primary tumor resected or non-resected were 17 and 26. The evaluable lesions were 26 primary lesions, 22 lymph node metastases, 12 liver metastases, 1 pancreas metastasis and 2 soft tissue metastases. Forty patients were evaluable for clinical response. Four patients achieved CR (10.0%), 13 PR (32.5%), ORR 42.5% (95% CI 27.2 - 57.8), 17 SD (42.5%) and 6 PD (15.0%). Overall response rate (ORR) for chemotherapy naive (1(st) line) and pretreated (2(nd) line) patients were 50.0% (14/28) and 25.0% (3/12), respectively. Median time to progress (mTTP) was 5 months and median overall survival (mOS) was 8 months. Forty-three patients were evaluable for toxicity, with Grade 3, 4 WHO toxicity of neutropenia in 7 patients (16.3%), thrombocytopenia in 3 patients (7.0%), nausea/vomiting in 1 patient (2.3%). There were no Grade 3, 4 peripheral neuropathy toxicity or any deaths during treatment. CONCLUSION: OXA-LV5FU2 is a high response regimen for advanced gastric cancer with mild toxicity, which can be practiced safely.

Adult↗
PubMed2003

[The comparative study of clinical therapy of secretory otitis media in nasopharyngeal carcinoma patients].

OBJECTIVE: To investigate the treatment of secretory otitis media in nasopharyngeal carcinoma (NPC) patients. METHOD: Fifty eight patients of NPC with secretory otitis media were divided into two group by random before radiotherapy. Patients were treated by nasal and nasopharyngeal debridement and cleansing and tympanic membrane puncturing suction in group I, while patients were treated by myringotomy or ventilation tube insertion in Group II. After the patients were followed up for six months, the two group were compared by efficient rate and complication rate. RESULTS: Fifty one out of total 58 patients survived after half an years follow-up. Statistics of surviving patients showed the efficient rate in group I was 82.1% versus 57.1% in group II. Differentiation was found between two group (chi 2 = 4.14, P < 0.05). Complication rate was 3.6% in group I and 28.6% in group II. There was differentiation between two group (chi 2 = 4.7, P < 0.05). CONCLUSION: The nasal and nasopharyngeal debridement and cleaning and eardrum puncturing suction was superior to myringotomy or ventilation tube insertion.

Adult↗
PubMed2003

[Overexpression of c-erbB-2 and hypoexpression of nm23 relating to poor prognosis of colorectal carcinoma].

OBJECTIVE: To investigate the relationship between expression of c-erbB-2, CD44v6 and nm23 gene proteins and the clinicopathological features of colorectal carcinomas. METHODS: Immunohistochemical technique was adopted to detect the protein expression of c-erbB-2, CD44v6 and nm23 genes in 92 cases of colorectal carcinomas. Of the 92 cases, 28 cases were followed up for more than 10 years, in which the prognosis was analyzed. RESULTS: Expression of c-erbB-2 and CD44v6 was correlating with UICC staging (P < 0.05), and c-erbB-2 was associated with prominent peritumoral lymphocytic infiltration (P < 0.05). In the 28 cases with followed-up data, univariant analysis revealed that the survival rate was correlated with histological grading, UICC staging, tumor growth pattern, peritumoral lymphocytic infiltration, and expression of c-erbB-2, CD44v6 and nm23. However, Cox stepwise proportional hazards analysis showed that only UICC staging, c-erbB-2 and nm23 status retained significant independently in prospecting prognosis. CONCLUSIONS: Besides UICC III and IV stage, overexpression of c-erbB-2 and decreased expression of nm23 are considered acceptable as the parameters in predicting of poor prognosis in colorectal carcinoma.

Adenocarcinoma↗
PubMed2003

[Cause and measure of short of quality control on Chinese medicine herbs].

Chinese medicine is short of quality control for three reasons. Firstly, near 90 percent Chinese medicine herbs are lack of quality standards and hard to be evaluated. Secondly, basal study falls behind relatively, which limites development speed of quality control and quality standard. Finally, Chinese medicine herbs haven't uniform refine operating norm. We must strengthen basal study, constitute the inspection norm of Chinese medicine herbs quality and establish perfect technical supervise system as fast as possible.

Animals↗
PubMed2003

[A comparative study of masticatory efficiency and mandibular movement pattern among patients with CD, COD and IOD].

OBJECTIVE: To compare the masticatory efficiency and the character of mandibular movement trace of the patients with complete denture (CD), complete overdenture (COD) and implant-supported overdenture (IOD). METHODS: A total of 42 subjects were rehabilitated with CD, COD and IOD respectively and wore the dentures at least half a year. Each study group was composed of 14 subjects. The masticatory function of patients were investigated by means of masticatory efficiency and mandibular movement trace. The characters of mandibular movement trace were evaluated from four aspects: the regulation of chewing cycle, centralization of end traces, the type of the contact slides and the type of the trace on the frontal plane. RESULTS: The average chewing efficiency of almond and jujube in the IOD patients was higher than that in the CD group (P < 0.01), and the chewing efficiency of almond in COD group was higher than that in the CD group (P < 0.01). In the IOD group, there were more patients with regular chewing cycle (P < 0.05) and centralized end traces (P < 0.01) in mandibular movement than those in the CD group and COD group. CONCLUSIONS: IOD and COD benefit the fully or partially edentulous patients with a relatively good masticatory function. The patients with IOD have more regular mandibular movement than those with CD.

Adult↗
PubMed2003

[The relationship of wire offset and lingual component force on first molar].

OBJECTIVE: To measure the strength of lingual component force on first molar while retraction canine by 150 g tractive force with different sizes of arch wire and with different widths of molar offset on the wire. METHODS: Wires with different sizes and different materials [0.40 mm and 0.45 mm stainless round wires, 0.40 mm and 0.45 mm Australia wires, 0.41 mm x 0.56 mm (0.016 x 0.022 inch) and 0.46 mm x 0.63 mm (0.017 x 0.025 inch) rectangular stainless wires] were ligated in ideal arch Typodont when the canine was retracted with 150 g force in the direction from the molar buccal hook to the central point of canine bracket's distal wing under different widths of molar offset (1 mm, 2mm, 3mm). the lingual force applied on the first molar was measured by a self-made dynamometer. RESULTS: 1. There is lingual component force applied to the first molar while retracting canine with 150 g tractive force. 2. the bigger the cross section area of the wire and the stronger the rigidity of the wire, the smaller the lingual component force turns. The ability of the wire in deducting the lingual component force is in direct ratio with the cross section area and the rigidity of the wire. 3. While the width of wire offset increases, the lingual force produced by the tractive force applied to the first molar decreases lineally. CONCLUSION: There is lingual force produced on the anchorage molar when retracting canine. In clinic for avoiding the lingual movement of the first molar, increasing the size of wire or increasing the width of wire offset is suggested.

Cuspid↗
PubMed2003

[Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol].

AIM: To study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol. METHODS: Pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol, norfloxacin, ciprofloxacin, enoxacin via nucleophilic substitution and esterification. The antibacterial activity of the nine target compounds were tested. RESULTS: Nine new compounds were synthesized (IIa-c and IIIa-f). The structure of the title compounds were identified by 1HNMR, MS as well as elementary analysis. CONCLUSION: Compounds IIa, IIb and IIc showed antibacterial activity, and were worth further studying.

Animals↗
PubMed2003

[Effect of exogenous selenium on soybean yield and its total N and P contents and on soil enzyme activities].

Based on pot experiment with black soil, the effects of various concentrations and various valence of exogenous selenium on soybean yield and its N and P contents and on soil enzyme activities were studied. The results showed that applying 0.25 microgram.g-1 soil and 0.5 microgram.g-1 soil of both Se4+ and Se6+ could increase soybean yield and its N content and promote soil urease activity, but decrease the P content of soybean and soil phosphatase activity. When the concentration of Se6+ was 0.5 microgram.g-1 soil, there was a significantly parabola relationship between the N content of soybean and soil urease activity; and when the concentration of Se6+ was 0.25 microgram.g-1 soil, there was a significantly parabola relationship between the P content of soybean and soil phosphatase activity. There were no significant relationships between the N and P contents of soybean and the activities of test soil enzymes when Se4+ was applied.

Crops, Agricultural↗
PubMed2003

[Associations of Rsa I polymorphism at the 5' flanking region of CYP2E1 and PON2 148 polymorphism in neonates with preterm delivery].

The objective is to investigate whether Rsa I polymorphism at the 5' flanking region of cytochrome P450 2E1 gene (CYP2E1) and paraoxonase 2 gene polymorphism (PON2 148) in neonates are associated with preterm delivery. Using standard questionnaires, 209 singleton live born mother-neonate pairs (include preterm cases and term controls) were investigated by the trained field workers with cross-sectional survey at the hospitals in Anqing, Anhui Province, China. Epidemiological and clinical data and blood samples were obtained from 209 mother-neonate pairs. CYP2E1 homozygous wild-type (+/+) is not associated with a shortened gestation among neonates, compared with CYP2E1 homozygous mutant-type (-/-)/CYP2E1 heterozygote (+/-) before and after adjustment confounders, however, PON2 Ala148Ala homozygote is significantly associated with a shortened gestation among neonates. When Rsa I polymorphism at the 5' flanking region of CYP2E1 and PON2 148 polymorphism were considered jointly, a significant shortened gestation was observed among neonates with the combined genotype of CYP2E1 homozygous wild-type and PON2 Ala148Ala homozygote. In conclusion, Rsa I polymorphism at the 5' flanking region of CYP2E1 in neonates is not associated with preterm delivery, however, PON2 148 polymorphism in neonates is significantly associated with preterm delivery. Furthermore, the gene interaction between Rsa I polymorphism at the 5' flanking region of CYP2E1 and PON2 148 polymorphism in neonates is significantly associated with preterm delivery.

5' Flanking Region↗
PubMed2003

Tumor necrosis factor-alpha gene G308A polymorphism is associated with the risk of preterm delivery.

OBJECTIVE: To investigate the association between polymorphism in tumor necrosis factor-alpha(TNF-alpha)/G308A and preterm delivery (PTD). Between July 1999 and June 2001, we conducted a molecular epidemiological study on genetic determinants of PTD at Anqing Hospital, China. METHODS: In a case-control-parent triads study, we investigated a total of 133 nuclear families: 79 normal gestational age families and 54 PTD families. A DNA extraction and polymerase chain reaction followed by restriction fragment length polymorphism analysis were used to genotype for the presence of TNF-alpha/G308A polymorphism. RESULTS: Gestational age was analyzed as a binary variable. Multiple logistic regression analysis results showed that TNF-alpha/A308A genotype was significantly increased the risk of preterm delivery (OR = 0.039, 95% CI: 1.14-128.75). In consistence with the population based multiple logistic regression analysis, Family Based Association Test (FBAT) analysis showed that TNF-alpha/308A allele was associated with preterm delivery as 308A-recessive inheritance model and 308A-additive inheritance model both gave rise to the significant result (P = 0.040 and P = 0.018 respectively). CONCLUSION: Carriage of the mutant 308A allele of TNF-alpha/G308A polymorphism is associated with preterm delivery, which may be genuine etiologic factors of PTD.

Alleles↗
PubMed2003

[Quantitative pathologic technique in prognostic identification of breast carcinoma with negative lymph node].

OBJECTIVE: To study the prognostic identification of lymph node negative breast carcinoma by quantitative pathologic technique. METHODS: Several morphometrical parameters, DNA content of cell nuclei were detected by means of a quantitative pathologic technique on 102 patients with lymph node negative invasive breast duct carcinoma. The effects of potential prognostic factors of lymph node negative breast cancer patients were assessed by Cox's proportional hazards regression model. RESULTS: DNA index, minimal diameter of nuclei, area of nuclei, maximal diameter of nuclei, and the perimeter of nuclei are important factors to influence the prognosis. CONCLUSION: Quantitative pathologic technique combined with valid statistical methods, as an objective means of assessing prognosis, may reliably improve the outcome in lymph node negative breast cancer.

Adult↗