Biomedical subjects

Li Yang

Publications and source records attributed to Li Yang.

273 records · Page 16Linked to original sources

PubMedDate not supplied

Cerebral infarction due to giant cell arteritis-three case reports.

The objective of this report was to explore the clinical features of patients with cerebral infarction due to giant cell (temporal) arteritis (GCA) and its characteristic changes in pathology, and on computed tomography (CT) and magnetic resonance imaging (MRI). Three cases of cerebral infarction due to GCA, treated during the past 2 years, were analyzed. Their clinical manifestations were observed carefully, their temporal artery biopsies were performed, their immunohistochemistries were done, and CT as well as MRI were used. The results showed that all the patients had new-onset headache and temporal artery abnormality when the disease began, and there was tremor on the right limbs of 1 patient; temporal artery biopsies revealed evidence of inflammatory cell infiltration in the arterial wall, mainly including T-lymphocytes and macrophages; small cerebral infarction foci were found on CT and MRI; and the responses to corticosteroid therapies were good. The results suggest that it is important to recognize the clinical features of cerebral infarction due to GCA, including the changes of pathology and on CT and MRI. In some cases, special attention is paid to differentiating between atherosclerotic infarction and infections to avoid misdiagnosis.

Aged↗

PubMedDate not supplied

The 3,4-dihydroxyl groups are important for trans-resveratrol analogs to exhibit enhanced antioxidant and apoptotic activities.

We compared the abilities of trans-resveratrol and seven analogs to inhibit an azo compound-induced peroxidation of linoleic acid in vitro and to induce apoptosis in cultured human leukemia cells. The results showed that both the antioxidant and apoptotic activities of the analogs containing 3,4-dihydroxyl groups were significantly higher than those of the trans-resveratrol and the other analogs. Hence, the 3,4-dihydroxyl groups were important for trans-resveratrol analogs to exhibit concurrent high antioxidant and apoptotic activities.

Antineoplastic Agents, Phytogenic↗

PubMedDate not supplied

Quantification of regional left ventricular systolic dysfunction in patients with coronary artery disease by pulsed Doppler tissue imaging.

OBJECTIVES: To analyze and compare quantitatively regional myocardial functional abnormalities of the left ventricle by pulsed Doppler tissue imaging (DTI) in patients with unstable angina (UA) and prior myocardial infarction (MI), and to explore the value of systolic velocity and time intervals in evaluating regional left ventricular systolic dysfunction. METHODS: Patients with coronary artery disease (CAD) were divided into UA (16 cases) and anterior wall MI (ant-MI, 21 cases) groups. Sixteen age-matched normal subjects served as the control group. The septal and lateral, anterior and inferior walls of the left ventricle were displayed, and basal and middle segments of each wall were selected for myocardial motion spectrum sampling. DTI parameters were: peak systolic myocardial velocity (s), regional pre-ejection period (PEP), time to peak of the systolic wave (Ts), regional ejection time (ET) and PEP/ET ratio. RESULTS: Compared with the control group, s was significantly lower in all segments in the ant-MI group, and in lateral and anterior segments in the UA group. It was even lower in the ant-MI than in the UA group, and in infarct compared with corresponding non-infarct segments in the ant-MI group. PEP and Ts were significantly longer in both the UA and the ant-MI groups. CONCLUSION: Not only s, but also PEP and Ts as measured by pulsed DTI are sensitive markers of regional left ventricular systolic dysfunction in patients with CAD; s and PEP may even indicate the severity of myocardial ischemia and aid in estimating the site of MI.

Adolescent↗