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Biomedical subjects

Lidija Popović

Publications and source records attributed to Lidija Popović.

7 recordsLinked to original sources
PubMedDate not supplied

[Primary localized cutaneous amyloidosis--lichen amyloidosis].

This case report presented a female patient with primary-localized-cutaneous-amyloidosis in the form of lichen amyloidosus. Primary-localized-cutaneous-amyloidosis is a rare idiopathic dermatosis caused by abnormal deposition of amyloid composed primarily of degenerated keratin filaments. In order to establish the final diagnosis, detailed clinical and laboratory investigations were performed, with a particular emphasis on pathohistological analysis of skin specimens, special stains, and electron microscopy.

Adult↗
PubMedDate not supplied

[Allergic granulomatous angiitis].

Allergic granulomatous angiitis (AGA)--Churg-Strauss syndrome, is a rare autoimmune disease characterized by three distinct clinical phases: prodromal, eosinophilic, and vasculitic, and most of respiratory symptoms and signs begin in the first two phases of the disease. Two female patients of different age, who fulfilled the diagnostic criteria for AGA, and were in different phases and with the different duration of the disease are presented. The first patient (24 years of age) was admitted to the hospital due to aggravation of asthma, heart failure, and polyneuropathy. The second one (45 years of age) was also hospitalized due to the worsening of asthma, polyneuropathy, and fever. Both were treated continuously with glucocorticoids. The older patient also received a total of six pulse doses of cyclophosphamide. Satisfactory response to such a treatment was achieved in both cases.

Adult↗
PubMedDate not supplied

[Breast carcinoma with melanocytic differentiation].

Azzopardi and Eusebi were the first to describe pigmented breast cancers in 1977. They postulated that the mammary cancer might become colonized by melanocytes at the expense of the epidermis, which was focally depleted of melanocytes, and that it occurred in most cases of breast cancers in which tumor cells reached the dermal-epidermal interface. Other authors suggested melanocytic differentiation of tumor cells. In this paper a case of a patient with ductal invasive breast cancer with partial melanocytic differentiation was presented, documented by HMB-45 and melan-A reactivity of tumor cells. Tumor was positive with antibodies for estrogen and progesterone receptors, pancytokeratin, negative with antibodies for S-100 protein and vimentin. Masson-Fontana reaction was negative. It was concluded that pigmented tumors should be differentiated from tumors with partial melanocytic differentiation, and that clinical significance of melanocytic differentiation should be analysed on larger number of cases.

Aged↗
PubMedDate not supplied

[Epithelioid vascular tumor].

Epithelioid vascular tumors are neoplasms formed by endothelial cells, morphologically similar to epithelial cells. Morphological shape of the cells in this tumors varies from benign to malignant forms, causing the diverse biological potential of the tumors. This case-report presents immunophenotypically interesting epithelioid vascular tumor of the upper vena cava manifested in thrombotic complications. It is characterized by solid growth of tumor cells and the attempt of forming vascular channels. According to immunophenotype, tumor cells corresponded to endothelial cells with low proliferative potential and vasoformative capability of forming intracellular lumina. For that reason this tumor manifested similarity with epithelioid hemangioendothelioma. However, it differentiated from the hemangioendothelioma by benign cytomorphological characteristics of tumor cells, absence of pathological mitoses, more intensive inflammatory infiltrate with eosinophylia and good tissue control, of tumor growth because of the presence of pericites. According to histological features and histochemical analyses the diagnosis of this tumor was established as an intravascular, solid, epithelioid hemangioma.

Female↗