A simple glycol nucleic acid.
A glycol nucleic acid (GNA) with an acyclic propylene glycol phosphodiester backbone forms stable antiparallel duplexes following the Watson-Crick base pairing rules.
Circular Dichroism↗
Biomedical subjects
Lilu Zhang
Publications and source records attributed to Lilu Zhang.
An extremely stable and orthogonal DNA base pair with a simplified three-carbon backbone.
A nucleotide C3HQ with a minimal three-carbon backbone displays unprecedented pairing strength and orthogonality in a homopair C3HQ:C3HQ in the presence of one equivalent of Cu2+. The pairing stability in DNA even exceeds the related base pair having the regular 2'-deoxyribose backbone. This discovery of a synergy between an artificial backbone and base-pairing scheme opens new avenues for the economical design of modified oligonucleotides with tailored properties.
Base Pairing↗
Ruthenium complexes as protein kinase inhibitors.
[reaction: see text] Replacing complex natural products with simple metal complexes could lead to a new class of metallopharmaceuticals in which the metal center plays mainly a structural role. A strategy is introduced for the creation of ruthenium complex-based protein kinase inhibitors 1 (X = CO or CH(2)), morphed out of the class of indolocarbazole inhibitors with the alkaloid staurosporine as its most prominent member.
Carbazoles↗
Synthesis and structure of a novel supramolecular Zn3Co8 assembly containing a linear Zn3 core.
Reaction of Zn(OAc)(2).2H2O (OAc = acetate) with LH2 in THF followed by reaction with Co2(CO)8 yields the novel supramolecular assembly Zn3L2(OAc)2[Co2(CO)6](4).0.5CH2Cl2, which was characterized by X-ray diffraction (LH2 = (CH2)3(N=CH-2-OH-5-C identical to CSiMe3C6H3)2 or N,N'-propylenebis(2-hydroxy-5-trimethylsilylethynl-1-aldimine).
Journal Article↗