Biomedical subjects

Lin Bian

Publications and source records attributed to Lin Bian.

5 recordsLinked to original sources

PubMed2006

Spectral fine-structures of low-frequency modulated distortion product otoacoustic emissions.

Biasing of the cochlear partition with a low-frequency tone can produce an amplitude modulation of distortion product otoacoustic emissions (DPOAEs) in gerbils. In the time domain, odd- versus even-order DPOAEs demonstrated different modulation patterns depending on the bias tone phase. In the frequency domain, multiple sidebands are presented on either side of each DPOAE component. These sidebands were located at harmonic multiples of the biasing frequency from the DPOAE component. For odd-order DPOAEs, sidebands at the even-multiples of the biasing frequency were enhanced, while for even-order DPOAEs, the sidebands at the odd-multiples were elevated. When a modulation in DPOAE magnitude was presented, the magnitudes of the sidebands were enhanced and even greater than the DPOAEs. The amplitudes of these sidebands varied with the levels of the bias tone and two primary tones. The results indicate that the maximal amplitude modulations of DPOAEs occur at a confined bias and primary level space. This can provide a guide for optimal selections of signal conditions for better recordings of low-frequency modulated DPOAEs in future research and applications. Spectral fine-structure and its unique relation to the DPOAE modulation pattern may be useful for direct acquisition of cochlear transducer nonlinearity from a simple spectral analysis.

Acoustic Stimulation↗

PubMed2004

Cochlear hysteresis: observation with low-frequency modulated distortion product otoacoustic emissions.

Low-frequency modulation of distortion product otoacoustic emissions (DPOAEs) can be used to estimate a nonlinear transducer function (fTr) of the cochlea. From gerbils, DPOAEs were measured while presenting a high-level bias tone. Within one period of the bias tone, the magnitudes of the cubic difference tone (CDT, 2f1 - f2) demonstrated two similar modulation patterns (MPs) each resembled the absolute value of the third derivative of the fTr. The center peaks of the MPs occurred at positive sound pressures for rising in bias pressure or loading of the cochlear transducer, and more negative pressures while decreasing bias amplitude or unloading. The corresponding fTr revealed a sigmoid-shaped hysteresis loop with counterclockwise traversal. Physiologic indices that characterized the double MP varied with primary level. A Boltzmann-function-based model with negative damping as a feedback component was proposed. The model was able to replicate the experimental results. Model parameters that fit to the CDT data indicated higher transducer gain and more prominent feedback role at lower primary levels. Both physiologic indices and model parameters suggest that the cochlear transducer dynamically changes its gain with input signal level and the nonlinear mechanism is a time-dependent feedback process.

Acoustic Stimulation↗

PubMed2004

Constructing a cochlear transducer function from the summating potential using a low-frequency bias tone.

A new method is developed to construct a cochlear transducer function using modulation of the summating potential (SP), a dc component of the electrical response of the cochlea to a sinusoid. It is mathematically shown that the magnitude of the SP is determined by the even-order terms of the power series representing a nonlinear function. The relationship between the SP magnitudes and the second derivative of the transducer function was determined by using a low-frequency bias tone to position a high-frequency probe tone at different places along the cochlear transducer function. Two probe tones (6 kHz and 12 kHz) ranging from 70 to 90 dB SPL and a 25-Hz bias tone at 130 dB SPL were simultaneously presented. Electric responses from the cochlea were recorded by an electrode placed at the round window to obtain the SP magnitudes. The experimental results from eight animals demonstrated that the SP magnitudes as a function of bias levels are essentially proportional to the second derivative of a sigmoidal Boltzmann function. This suggests that the low-frequency modulated SP amplitude can be used to construct a cochlear transducer function.

Acoustic Stimulation↗

PubMed2004

Cochlear compression: effects of low-frequency biasing on quadratic distortion product otoacoustic emission.

Distortion product otoacoustic emissions (DPOAEs) are generated from the nonlinear transduction n cochlear outer hair cells. The transducer function demonstrating a compressive nonlinearity can be estimated from low-frequency modulation of DPOAEs. Experimental results from the gerbils showed that the magnitude of quadratic difference tone (QDT, f2-f1) was either enhanced or suppressed depending on the phase of the low-frequency bias tone. Within one period of the bias tone, QDT magnitudes exhibited two similar modulation patterns, each resembling the absolute value of the second derivative of the transducer function. In the time domain, the center notches of the modulation patterns occurred around the zero crossings of the bias pressure, whereas peaks corresponded to the increase or decrease in bias pressure. Evaluated with respect to the bias pressure, modulated QDT magnitude displayed a double-modulation pattern marked by a separation of the center notches. Loading/unloading of the cochlear transducer or rise/fall in bias pressure shifted the center notch to positive or negative sound pressures, indicating a mechanical hysteresis. These results suggest that QDT arises from the compression that coexists with the active hysteresis in cochlear transduction. Modulation of QDT magnitude reflects the dynamic regulation of cochlear transducer gain and compression.

Acoustic Stimulation↗

PubMed2002

Deriving a cochlear transducer function from low-frequency modulation of distortion product otoacoustic emissions.

In this paper, a new method is introduced to derive a cochlear transducer function from measuring distortion product otoacoustic emissions (DPOAEs). It is shown that the cubic difference tone (CDT, 2f1-f2) is produced from the odd-order terms of a power series that approximates a nonlinear function characterizing cochlear transduction. Exploring the underlying mathematical formulation, it is found that the CDT is proportional to the third derivative of the transduction function when the primary levels are sufficiently small. DPOAEs were measured from nine gerbils in response to two-tone signals biased by a low-frequency tone with different amplitudes. The CDT magnitude was obtained at the peak regions of the bias tone. The results of the experiment demonstrated that the shape of the CDT magnitudes as a function of bias levels was similar to the absolute value of the third derivative of a sigmoidal function. A second-order Boltzmann function was derived from curve fitting the CDT data with an equation that represents the third derivative of the Boltzmann function. Both the CDT-bias function and the derived nonlinear transducer function showed effects of primary levels. The results of the study indicate that the low-frequency modulated DPOAEs can be used to estimate the cochlear transducer function.

Acoustic Stimulation↗