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Linda G Shapiro

Publications and source records attributed to Linda G Shapiro.

8 recordsLinked to original sources

Symbolic signatures for deformable shapes.

Recognizing classes of objects from their shape is an unsolved problem in machine vision that entails the ability of a computer system to represent and generalize complex geometrical information on the basis of a finite amount of prior data. A practical approach to this problem is particularly difficult to implement, not only because the shape variability of relevant object classes is generally large, but also because standard sensing devices used to capture the real world only provide a partial view of a scene, so there is partial information pertaining to the objects of interest. In this work, we develop an algorithmic framework for recognizing classes of deformable shapes from range data. The basic idea of our component-based approach is to generalize existing surface representations that have proven effective in recognizing specific 3D objects to the problem of object classes using our newly introduced symbolic-signature representation that is robust to deformations, as opposed to a numeric representation that is often tied to a specific shape. Based on this approach, we present a system that is capable of recognizing and classifying a variety of object shape classes from range data. We demonstrate our system in a series of large-scale experiments that were motivated by specific applications in scene analysis and medical diagnosis.

Algorithms↗

Of mice and men: design of a comparative anatomy information system.

In previous work, we proposed an approach called the Structural Difference Method (SDM) to correlating the anatomy of Homo sapiens with selected species, using the Foundational Model of Anatomy (FMA) as a framework and graph matching as a method, for determining similarities and differences between species. In this paper, we present the design of a comparative anatomy information system that utilizes the SDM and allows users to issue queries to determine the similarities and differences between two species. Our system will serve as a pilot project for cross-species anatomical information collection, storage, and retrieval. The underlying data structure of a mapping, and the syntax and semantics of the system's query language, are presented.

Anatomy↗

A symbolic shaped-based retrieval of skull images.

In this work, we describe a novel symbolic representation of shapes for quantifying skull abnormalities in children with craniosynostosis. We show the efficacy of our work by demonstrating an application of this representation in shape-based retrieval of skull morphologies. This tool will enable correlation with potential pathogenesis and prognosis in order to enhance medical care.

Algorithms↗

Processes and problems in the formative evaluation of an interface to the Foundational Model of Anatomy knowledge base.

The Digital Anatomist Foundational Model of Anatomy (FMA) is a large semantic network of more than 100,000 terms that refer to the anatomical entities, which together with 1.6 million structural relationships symbolically represent the physical organization of the human body. Evaluation of such a large knowledge base by domain experts is challenging because of the sheer size of the resource and the need to evaluate not just classes but also relationships. To meet this challenge, the authors have developed a relation-centric query interface, called Emily, that is able to query the entire range of classes and relationships in the FMA, yet is simple to use by a domain expert. Formative evaluation of this interface considered the ability of Emily to formulate queries based on standard anatomy examination questions, as well as the processing speed of the query engine. Results show that Emily is able to express 90% of the examination questions submitted to it and that processing time is generally 1 second or less, but can be much longer for complex queries. These results suggest that Emily will be a very useful tool, not only for evaluating the FMA, but also for querying and evaluating other large semantic networks.

Anatomy↗

An approach to the anatomical correlation of species through the Foundational Model of Anatomy.

The increasing need for extrapolating information from one species to another has been highlighted by contemporary research in bioinformatics, genomics, proteomics, and animal models of human disease, as well as other fields. We propose an approach to correlating the anatomy of Homo sapiens with selected species, using the Foundational Model of Anatomy (FMA) as a framework, and graph matching as a method, for determining similarities and differences in the nodes and relationships (edges) defined by the attributed graph of the FMA. We illustrate our approach by comparing anatomical structures of mouse and human that present prototypical mapping problems.

Anatomy↗

Shape-based cortical surface segmentation for visualization brain mapping.

We describe a knowledge-based approach to cortical surface segmentation that uses learned knowledge of the overall shape and range of variation of the cortex (excluding the detailed gyri and sulci) to guide the search for the grey-CSF boundary in a structural MRI image volume. The shape knowledge is represented by a radial surface model, which is a type of geometric constraint network (GCN) that we hypothesize can represent shape by networks of locally interacting constraints. The shape model is used in a protocol for visualization-based mapping of cortical stimulation mapping (CSM) sites onto the brain surface, prior to integration with other mapping modalities or as input to existing surface analysis and reconfiguration programs. Example results are presented for CSM data related to language organization in the cortex, but the methods should be applicable to other situations where a realistic visualization of the brain surface, as seen at neurosurgery, is desired.

Brain Mapping↗

A rule-based model for local and regional tumor spread.

Prediction of microscopic spread of tumor cells is becoming critically important in the decision making process in planning radiation therapy for cancer. Until recently, radiation treatment of head and neck cancer has been conservative, treating large regions to insure eradication of disease. However, if it is known that regional spread is confined, a more focused treatment can be considered, with the payoff of reducing or eliminating morbidity due to irradiating healthy tissue in the vicinity of node groups. Knowledge about the occurrence of micrometastases comes mainly from pathology reports in connection with surgery. As the data accrue, it will be possible and necessary to represent this knowledge in a symbolic computational model. Our work reports on the feasibility of modeling this knowledge using published data.

Head and Neck Neoplasms↗

Head and neck lymph node region delineation with 3-D CT image registration.

The success of radiation therapy depends critically on accurately delineating the target volume, which is the region of known or suspected disease in a patient. Methods that can compute a contour set defining a target volume on a set of patient images will contribute greatly to the success of radiation therapy and dramatically reduce the workload of radiation oncologists, who currently draw the target by hand on the images using simple computer drawing tools. The most challenging part of this process is to estimate where there is microscopic spread of disease. We are developing methods for automatically selecting and adapting standardized regions of tumor spread based on the location of lymph nodes in a standard or reference case, together with image registration techniques. The best available image registration techniques (deformable transformations computed using "mutual information" optimization) appear promising but will need to be supplemented by anatomic knowledge-based methods to achieve a clinically acceptable match.

Algorithms↗