[Estrogen-dependent angioedema].
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Angioedema↗
Biomedical subjects
Line Bjørge
Publications and source records attributed to Line Bjørge.
Failed medical termination of twin pregnancy with mifepristone: a case report.
Medical abortion with mifepristone and misoprostol is a two-step process where some women will change their minds about going through the abortion process after taking mifepristone. Of these, some pregnancies will continue. A woman with a twin pregnancy who changed her mind is presented. Twin pregnancies may need higher dosages of mifepristone than single pregnancies due to the presence of two corpora lutea and increased amount of trophoblast tissue. There is little, if any, documentation regarding congenital abnormalities after taking mifepristone. Therefore, there is little evidence to support persuasion of the patient to continue the abortion process with the prostaglandin analouge.
Abortifacient Agents, Steroidal↗
Heterogeneous expression of CD59 on human Purkinje cells.
The expression of CD59 and other complement regulators was studied in human cerebellum from 14 individuals with no cerebellar pathology, from one patient with multiple sclerosis (MS) and from two patients with paraneoplastic cerebellar degeneration (PCD). CD59 was present on the Purkinje cells at various levels in eight of the 14 cases with no cerebellar pathology. CD59 was also present on the Purkinje cells of the patient with MS, but not on the scarce remaining Purkinje cells of the two patients with PCD. Other complement regulators (CD35, CD46 and CD55) were not expressed on the Purkinje cells, whereas CD59, CD46 and CD55 were present on the molecular, granulosa and endothelial cells. The results suggest that Purkinje cells not expressing CD59 could be especially prone to complement-mediated damage.
Aged↗
[Medical abortion--the first Norwegian experiences].
BACKGROUND: Medical abortion was first introduced in Norway in April 1998. The aim of this study is to assess the efficacy, side effects and acceptability of medical abortion with mifepristone and vaginally administered misoprostol in a Norwegian population. MATERIALS AND METHODS: The study included the first consecutive 226 women with gestational age of < 63 days who requested non-surgical abortion in the first year at the first Norwegian hospital using this regime. All women received a single dose of mifepristone 600 mg orally followed by 800 microgram of misoprostol vaginally after 48 hours. Complications were the principal outcome measure. We also took note of side effects such as abdominal pain and bleeding and inquired about how acceptable the treatment was for the women concerned. RESULTS: 95 % of the women had an uncomplicated termination of their pregnancies. The side effects were few and tolerable and the method's acceptability high. INTERPRETATION: The combination of mifepristone and vaginally administered misoprostol is effective and safe, has few side effects, and is well accepted by Norwegian women.
Abortifacient Agents, Nonsteroidal↗
Paroxysmal nocturnal hemoglobinuria in pregnancy.
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia in which a defect of glycophosphatidylinositol (GPI)-anchored proteins in the cell membrane of bone marrow stem cells leads to increased sensitivity of the red cells to complement, causing intravascular hemolysis and hemoglobinuria. Other clinical features of this disease are cytopenia and an increased frequency of thrombotic events. We report a case of a pregnant woman with PNH on high-dosage anticoagulation therapy, the follow-up during the pregnancy, the delivery and the postpartum period. The obstetric literature on women with PNH is reviewed, the maternal and fetal risks are evaluated and the management of pregnancies and deliveries in such patients are discussed. During the pregnancy our patient was hypertransfused and used anticoagulation treatment. A healthy child was delivered in week 37 by cesarean section because of premature rupture of the membranes, unsuccessful induction and intrauterine infection. Because of bleeding problems a hysterectomy also had to be performed. In the postpartum period the patient developed her second episode of a liver vein thrombosis. She recovered gradually and 18 months after the delivery her disease is now in a stable phase. The literature shows a high maternal morbidity and mortality among pregnant PNH patients. Fetal wastage and prematurity rate are also high. Pregnancy in patients with PNH represents a high-risk situation for both the mother and the child and should not be recommended. A pregnant PNH woman should be followed closely by both obstetricians and hematologists.
Adult↗