Biomedical subjects

Lingyan Mo

Publications and source records attributed to Lingyan Mo.

5 recordsLinked to original sources

PubMed2006

Threshold estimation in children using auditory steady-state responses to multiple simultaneous stimuli.

OBJECTIVE: It was the aim of this study to explore the use of auditory steady-state response (ASSR) to multiple simultaneous stimuli for threshold estimation in young children. METHOD: The subjects consisted of 40 children, aged from 6 months to 5 years, with variant degrees of sensorineural hearing loss. Simultaneous tonepips (0.5, 1, 2 and 4 kHz) with an amplitude modulated at different rates from 77 to 103 Hz were presented to both ears by insert phones. All children were tested with ASSR and age-appropriate behavioral tests. RESULTS: We found that (1) ASSR thresholds were usually higher than behavioral thresholds with a difference of 8-15 dB, (2) the behavioral thresholds were significantly correlated with ASSR thresholds (p = 0.000), and (3) there was a great difference between ASSR thresholds and behavioral thresholds found in a child with auditory neuropathy. CONCLUSION: Being objective, frequency specific and well correlated with behavioral thresholds, ASSR to multiple simultaneous stimuli was proven to be a good tool to predict behavioral hearing thresholds.

Acoustic Stimulation↗

PubMed2005

[The development of auditory capability for infants after cochlear implantation].

OBJECTIVE: The purpose of this study is to analyze the auditory capability of infants before and after cochlear implantation by using IT-MAIS questionnaire. METHOD: Eighty-six prelingually deaf patients participated in this study. They received a cochlear implant at the age of 1 to 3 yr. The audiologists who were trained for the research used the IT-MAIS questionnaire. Audiologists asked for the parents' answers face to face and recorded all the information about the patient's spontaneous auditory behavioural responses including vocalization, behaviour, spontaneous alerting to sound and deriving meaning from sound. The evaluation was performed before operation and 1 month, 3 months, 6 months, 1 year after switch-on. RESULT: The scores of question 1 were significantly different between pre-operation and 1, 3, 6, 12 months after switch-on (P = 0.000, 0.000, 0.000, 0.000). The scores of question 2 were significantly different between pre-operation and 6, 12 months after switch-on (P = 0.000, 0.000). The scores of question 3 were significantly different between pre-operation and 3, 6, 12 months after switch-on (P = 0.001, 0.000, 0.000). The scores of question 4 were significantly different between pre-operation and 3, 6, 12 months after switch-on (P = 0.002, 0.000, 0.000). The scores of question 5 were significantly different between pre-operation and 1, 3, 6, 12 months after switch-on (P = 0.046, 0.00, 0.000, 0.000, 0.000). The scores of question 6 were significantly different between pre-operation and 3, 6, 12 months after switch-on (P = 0.037, 0.000, 0.000). The scores of question 7 were significantly different between pre-operation and 3, 6, 12 months after switch-on ( P = 0.000, 0.000, 0.000). The scores of question 8 were significantly different between pre-operation and 6, 12 months after switch-on (P = 0.001, 0.001). The scores of question 9 were significantly different between pre-operation and 3, 6, 12 months after switch-on ( P = 0.023, 0.000, 0.000). The scores of question 10 were significantly different between pre-operation and 12 months after switch-on (P = 0.048). CONCLUSION: Most of the patients showed no consistent response to sound in everyday life before implantation. After cochlear implantation, a significant increase in auditory capability occurred. The children demonstrated faster development of vocalization behaviour and spontaneous alerting to sound than deriving meaning from sound.

Audiometry, Speech↗

PubMed2005

[Comparing the characteristics of psychophysical tests between cochlear implant children with large vestibular aqueduct syndrome and normal inner ear].

OBJECTIVE: The purpose of this study is to compare the characteristics of psychophysical tests between cochlear implant children with large vestibular aqueduct syndrome and normal inner ear and to analyse the characteristics of psychophysical and impedance tests for cochlear implant patients with large vestibular aqueduct syndrome. METHOD: One hundred and thirty-one cochlear implant pre-lingual deafness patients participated in this study. They received cochlear implant surgery at the age of 1.5 to 12 years old from Nov, 1998 to Aug, 2003. The patients were divided into two groups. Group A had 111 patients with normal inner ear. Group B had 20 patients with radiographically proven large vestibular aqueduct syndrome. All of the patients were inserted with Nucleus 24M. The time of the first programming session was approximately 4 weeks after surgery. The psychophysical tests included T and C-Level tests. The programming techniques used in the test were suitable for the age of the patients. The R116 and R126 software were used to test the impedance of the electrodes automatically. RESULT: Using the independent-samples t-test, the impedance and T/C-Level of each electrode did not differ significantly between group A and B ( P > 0.05). The impedance and T/C-Level were not significantly different between group A and B at the time of switch-on, 1 week, 2 weeks, 3 weeks, 2 months, 3 months, 6 months, 9 months and 1 year after switch-on (P > 0.05). CONCLUSION: The parameters of mapping were not significantly different between cochlear implant children with large vestibular aqueduct syndrome and normal inner ear. The management and procedure of mapping used in cochlear implant children with normal inner ear can be used in the children with large vestibular aqueduct syndrome.

Case-Control Studies↗

PubMed2004

[The psychophysical tests in different age of patients with cochlear implants].

OBJECTIVE: The aim of this research is to analyse and compare the psychophysical tests in different age of patients with a cochlear implant. METHOD: One hundred and seventy patients with Nucleus CI24M cochlear implant system participated in this study. The patients were divided into four groups according to their age. They were group A (<3 year), B(3-<6 year) C(6-12 year) and D(>12 year). The psychophysical tests included T and C-Level evaluation. RESULT: C-Levels of each electrode (except electrode No. 20) were significantly different between group A and D at the time of one month after switch-on (P<0.01, P<0.05 for the No. 2, 18, 19, 21, 22 electrode). The normalized differences between used C-Levels and C-Levels for group D were significantly higher than the other three groups at the switch-on session (P<0.01, P<0.05 between group D and C). The normalized differences between used C-Levels and C-Levels were significantly different for the group A and D at one week after first programming session (P<0.05). CONCLUSION: T and C-Level for different age groups were different. The normalized differences between used C-Levels and C-Levels were significantly different among the four groups in the few weeks after switch-on.

Adolescent↗

PubMed2002

[Comparison of neural response telemetry thresholds with behavioral T/C levels].

OBJECTIVE: To provide an objective method to estimate T-levels and C-levels using neural response telemetry (NRT) thresholds for children, from whom we can not get accurate responses because they are very young or have other disabilities, by comparing NRT thresholds and T/C levels. METHODS: Seventy patients implanted with the nucleus CI24M multiple cochlear implant system participated in this study. 329 electrodes were tested. The software used in this study was NRT 2.04. Monopolar stimulation mode was used during NRT threshold measurement. No. 3, 5, 10, 15, 20 electrodes were tested for each patient. The T-levels and C-levels were obtained at the same visit. RESULTS: 92.7% of all the tested electrodes recorded NRT responses. There were variations in the amplitudes and thresholds of NRT responses across subjects and electrodes. NRT thresholds fell within the different points of the MAP dynamic range. The mean of NRT thresholds was shown to fall between the mean of T-levels and C-levels. The NRT thresholds and T/C levels reduced from basal to apical ends of the cochlear. CONCLUSIONS: Considerable variability across subjects was noted. So it is difficult to estimate T-levels and C-levels accurately by testing only NRT thresholds only. NRT technology provides a new objective method for estimating T-levels and C-levels for children who are unable to cooperate with audiologists during mapping after operation. The new NRT technology should be improved in the future.

Adolescent↗