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Biomedical subjects

Lior Heller

Publications and source records attributed to Lior Heller.

10 recordsLinked to original sources
PubMed2006

Lower extremity reconstruction.

The current recommendation for surgical treatment of tumors of the lower extremity is a limb-sparing resection. Limb-sparing resection coupled with complex reconstructive techniques and complemented by new chemotherapeutic agents and adjuvant radiation therapy has allowed us to achieve survival rates that are comparable to those of amputation with a better functional outcome. Recent advances in microsurgical techniques and the associated technologies and a better understanding of microvascular anatomy has allowed us to customize flaps to the specific needs of the patients and to achieve a lower donor site morbidity. Increased communication between the specialties of the multidisciplinary treatment team has also improved outcomes. The reconstructive component has become an integral part of the multidisciplinary care for patients with lower extremity tumors. It not only allows them to rapidly resume adjuvant therapies but also enables them to more easily resume their activities of daily living.

Adult↗
PubMed2006

Management of abdominal wound dehiscence using vacuum assisted closure in patients with compromised healing.

BACKGROUND: Restoration of the abdominal wall's integrity after postoperative wound dehiscence is frequently performed in a delayed fashion, necessitating a temporary dressing of the dehisced wound. METHODS: The Vacuum Assisted Closure (VAC) system (Kinetic Concepts, Inc., San Antonio, TX) was used in 21 patients with postoperative abdominal wound dehiscences that could not be closed immediately and who were at high risk for healing complications. The VAC device was used in conjunction with sharp debridement and it was maintained on a continuous mode with a negative pressure of -75 to -125 mm Hg. The dressing was changed every 2 days. VAC therapy was continued until the integrity of the abdominal wall was reestablished by surgical procedures or secondary healing. RESULTS: Thirteen patients had fascial dehiscence, and 9 of them had frank bowel exposure. Definitive fascial closure was performed in 9 of 13 patients with fascial dehiscence. Stable cutaneous coverage was subsequently achieved in all patients by local abdominal skin flap advancement (6), skin grafting (9), or secondary intention healing (6). Seven patients had part of their VAC therapy as outpatients. The complications included a low-output small bowel enterocutaneous fistula in 2 patients and partial skin graft loss in 1 patient. The fistulae resolved after operative treatment (1) or conservative treatment (1). CONCLUSION: Integration of the VAC system in the management of post-laparotomy wound dehiscence in patients with compromised wound healing appears to be successful and should be considered in such patients to provide a stable, healed wound.

Abdominal Wall↗
PubMed2005

The anchor tragal flap: a method of preserving the natural pretragal depression during rhytidectomy.

BACKGROUND: The delicate shape of the tragus and the pretragal depression are fine landmarks on the face that are usually lost during conventional rhytidectomy. A relatively simple technique to preserve the natural pretragal depression after face lift has been implemented in the authors' practice. It provides an almost invisible incisional scar and avoids tragal distortion. METHODS: Incision starts around the sideburn in a curvilinear fashion toward the helix and continues vertically down into the tragal margin and around the earlobe retroauricularly. The pretragal depression is created by separating the facial attachments and deepening the space anterior to the tragal cartilage and external auditory canal. The facial attachment is turned over and sutured over the parotid fascia with several 4-0 polydioxanone sutures. The base of the tragal flap created to fit into the tragus is anchored to the deep tissues in front of the tragus with two sutures of 5-0 polypropylene. The rest of the skin is closed in two layers and the tragal flap is inset without tension. RESULTS: The addition of this component to the operation implemented in more than 300 patients did not significantly elongate the operative time. Complications encountered included partial necrosis of the skin that healed with secondary healing (two patients), pretragal indentation that was released under local anesthesia (two patients), and loss of the pretragal definition (three patients). Preservation of the natural appearance in the tragal and pretragal area was mentioned by the patient as a positive feature. CONCLUSIONS: Re-creation of the natural tragus and pretragal depression without some of the surgical stigmata resultant from the loss of these delicate landmarks during a face lift has improved the aesthetic outcome of the authors' rhytidectomy patients.

Adult↗
PubMed2005

Strategies and options for free TRAM flap breast reconstruction in patients with midline abdominal scars.

BACKGROUND: Patients who have a midline abdominal scar from previous abdominal surgery often present a challenge when use of a transverse rectus abdominis myocutaneous (TRAM) flap is desired for breast reconstruction. In this study, the authors reviewed their experience with the TRAM flap for breast reconstruction in patients with midline abdominal scars to evaluate the various strategies used to optimize reconstructive outcomes. METHODS: Between January of 1994 and December of 2001, 43 patients with a midline abdominal scar underwent unilateral autologous tissue breast reconstruction with a TRAM flap at The University of Texas, M. D. Anderson Cancer Center. RESULTS: The mean age of the midline abdominal scar was 13 years (range, 4 to 45 years). In 26 patients, only free hemi-TRAM flaps were used for breast reconstruction. Free TRAM flaps were used in nine patients in whom zone II across the midline scar had an adequate blood supply and was able to be incorporated into the flap for breast reconstruction. In five patients, blood supplies from both sides of the TRAM flap were used to augment perfusion to the tissue across the midline scar. In three patients with infraumbilical midline scars, a free TRAM flap was designed higher in the abdomen so that the superior half of the flap was scar-free. CONCLUSIONS: Various strategies are available for autologous tissue breast reconstruction using a free TRAM flap in patients with a previous midline abdominal surgical scar. In some cases, the TRAM flap tissue across the midline scar can be used reliably for breast reconstruction.

Abdomen↗
PubMed2005

Halofuginone inhibits collagen deposition in fibrous capsules around implants.

Fibrous capsule formation around implants remains a difficult problem that has been studied for decades. The etiology is elusive, but the end result is the deposition of a dense collagenous capsule around implanted materials. The purpose of this study was to determine the effects of a type I collagen synthesis inhibitor, halofuginone, on fibrous capsule formation around implanted materials. Silastic disks were implanted subcutaneously into 4 groups of adult male rats for up to 8 weeks. Group 1 received drug throughout the study, group 2 received drug during the first half only, group 3 received drug during the second half only, and the control group received no drug. Implants were removed and histology of the capsules was examined. A collagen index score was calculated from digital images of trichrome-stained histologic sections, which permitted semiquantitative comparison of collagen content among the 4 groups. The collagen index values clearly indicate that halofuginone effectively inhibited collagen deposition within the capsule around the implanted disks. Halofuginone treatment also resulted in a decrease in the collagen index score in rat skin, indicating that halofuginone may affect preexisting collagenous structures. The ability of halofuginone to inhibit collagen deposition in new and preexisting fibrous capsules suggests that it may be a useful adjunct to minimize the formation of capsules around implantable prostheses.

Animals↗
PubMed2002

Two-stitch technique for distal shaft hypospadias repair.

The authors present a new technique for distal shaft hypospadias repair using a flip flap fashioned with only two stitches. In raising the flap, the tissues lateral and proximal to the flap are undermined but there is no undermining beneath the flap. The flap is sutured up to the glans with two 4-0 Vicryl sutures. No sutures are placed at the lateral edges of the flap to create the "tube" of the neo-urethra, and no postoperative urinary drainage is used. Thirty-three children with distal shaft hypospadias underwent the "two-stitch" flip flap operation. The complications were one fistula and one case of urinary retention. The technique is an easy method for reconstructing distal penile hypospadias with a very low rate of complications and is suitable for an outpatient surgical setting.

Child↗