Biointerfacing polyelectrolyte microcapsules.
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Capsules↗
Biomedical subjects
Liqin Ge
Publications and source records attributed to Liqin Ge.
Phospholipase A2 hydrolysis of mixed phospholipid vesicles formed on polyelectrolyte hollow capsules.
Mixtures of the phospholipids L-alpha-dimyristoylphosphatidic acid (DMPA) and L-alpha-dipalmitoylphosphatidylcholine (DPPC) have been successfully adsorbed onto the charged surface of multilayer polyelectrolyte capsules to form a novel vesicle. Leaving such vesicles in phospholipase A(2) solution, we observed the hydrolysis reaction on the surface of the lipid/polymer vesicles and a permeability change before and after the reaction by confocal-laser scanning microscopy (CLSM). A capsule with adjustable permeability was constructed. This method may provide new features for drug-release vesicles.
1,2-Dipalmitoylphosphatidylcholine↗
Polymer-stabilized phospholipid vesicles formed on polyelectrolyte multilayer capsules.
Phospholipid vesicles on polyelectrolyte multilayer shells can be stabilized against ethanol by coating a single cationic polyelectrolyte. Confocal laser scanning microscopy (CLSM) proved that the lipids were stabilized by cationic polyelectrolytes and the permeability to small hydrophilic dyes was decreased. Measurements of fluorescence recovery after photo-bleaching (FRAP) with individual capsules enable quantification of release profiles.
Biopolymers↗